{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T01:31:04Z","timestamp":1792891864952,"version":"4.5.0"},"reference-count":26,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:title>This Clinical Report was revised. See https:\/\/doi.org\/10.1542\/peds.2025-073627.<\/jats:title>\n                  <jats:p>Data from large randomized clinical trials indicate that therapeutic hypothermia, using either selective head cooling or systemic cooling, is an effective therapy for neonatal encephalopathy. Infants selected for cooling must meet the criteria outlined in published clinical trials. The implementation of cooling needs to be performed at centers that have the capability to manage medically complex infants. Because the majority of infants who have neonatal encephalopathy are born at community hospitals, centers that perform cooling should work with their referring hospitals to implement education programs focused on increasing the awareness and identification of infants at risk for encephalopathy, and the initial clinical management of affected infants.<\/jats:p>","DOI":"10.1542\/peds.2014-0899","type":"journal-article","created":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T21:34:37Z","timestamp":1401140077000},"page":"1146-1150","source":"Crossref","is-referenced-by-count":330,"title":["Hypothermia and Neonatal Encephalopathy"],"prefix":"10.1542","volume":"133","author":[{"name":"COMMITTEE ON FETUS AND NEWBORN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2014,6,1]]},"reference":[{"issue":"2","key":"2026012711213407600_B1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jpeds.2005.12.009","article-title":"Hypothermia and perinatal asphyxia: executive summary of the National Institute of Child Health and Human Development workshop.","volume":"148","author":"Higgins","year":"2006","journal-title":"J Pediatr"},{"issue":"3","key":"2026012711213407600_B2","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1542\/peds.2005-2950","article-title":"Hypothermia: a neuroprotective therapy for neonatal hypoxic-ischemic encephalopathy.","volume":"117","author":"Blackmon","year":"2006","journal-title":"Pediatrics"},{"key":"2026012711213407600_B3"},{"issue":"1","key":"2026012711213407600_B4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0378-3782(98)00033-4","article-title":"The \u2018pharmacology\u2019 of neuronal rescue with cerebral hypothermia.","volume":"53","author":"Gunn","year":"1998","journal-title":"Early Hum Dev"},{"issue":"4 pt 1","key":"2026012711213407600_B5","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1542\/peds.102.4.885","article-title":"Selective head cooling in newborn infants after perinatal asphyxia: a safety study.","volume":"102","author":"Gunn","year":"1998","journal-title":"Pediatrics"},{"issue":"4","key":"2026012711213407600_B6","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1542\/peds.106.4.684","article-title":"Pilot study of treatment with whole body hypothermia for neonatal encephalopathy.","volume":"106","author":"Azzopardi","year":"2000","journal-title":"Pediatrics"},{"issue":"3","key":"2026012711213407600_B7","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1542\/peds.2004-1587","article-title":"Hemodynamics among neonates with hypoxic-ischemic encephalopathy during whole-body hypothermia and passive rewarming.","volume":"117","author":"Gebauer","year":"2006","journal-title":"Pediatrics"},{"issue":"9460","key":"2026012711213407600_B8","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0140-6736(05)17946-X","article-title":"Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial.","volume":"365","author":"Gluckman","year":"2005","journal-title":"Lancet"},{"issue":"15","key":"2026012711213407600_B9","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy.","volume":"353","author":"Shankaran","year":"2005","journal-title":"N Engl J Med"},{"issue":"14","key":"2026012711213407600_B10","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","article-title":"Moderate hypothermia to treat perinatal asphyxial encephalopathy.","volume":"361","author":"Azzopardi","year":"2009","journal-title":"N Engl J Med"},{"issue":"3","key":"2026012711213407600_B11","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jpeds.2010.03.030","article-title":"Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: a multicenter randomized controlled trial in China.","volume":"157","author":"Zhou","year":"2010","journal-title":"J Pediatr"},{"issue":"4","key":"2026012711213407600_B12","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2009-2441","article-title":"Systemic hypothermia after neonatal encephalopathy: outcomes of neo.nEURO.network RCT.","volume":"126","author":"Simbruner","year":"2010","journal-title":"Pediatrics"},{"issue":"8","key":"2026012711213407600_B13","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1001\/archpediatrics.2011.43","article-title":"Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial.","volume":"165","author":"Jacobs","year":"2011","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"6","key":"2026012711213407600_B14","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1001\/archpediatrics.2011.1772","article-title":"Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis.","volume":"166","author":"Tagin","year":"2012","journal-title":"Arch Pediatr Adolesc Med"},{"key":"2026012711213407600_B15"},{"issue":"22","key":"2026012711213407600_B16","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1056\/NEJMoa1112066","article-title":"Childhood outcomes after hypothermia for neonatal encephalopathy.","volume":"366","author":"Shankaran","year":"2012","journal-title":"N Engl J Med"},{"issue":"2","key":"2026012711213407600_B17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/pr.2011.30","article-title":"CoolCap Trial Group. Seven-to eight year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy.","volume":"71","author":"Guillet","year":"2012","journal-title":"Pediatr Res"},{"issue":"5","key":"2026012711213407600_B18","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1542\/peds.2006-2839","article-title":"CoolCap Study Group. Determination of outcomes after head cooling for neonatal encephalopathy.","volume":"119","author":"Wyatt","year":"2007","journal-title":"Pediatrics"},{"issue":"3","key":"2026012711213407600_B19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1542\/peds.2007-1673","article-title":"Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomes.","volume":"122","author":"Laptook","year":"2008","journal-title":"Pediatrics"},{"key":"2026012711213407600_B20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1471-2431-12-84","article-title":"The Vermont Oxford Neonatal Encephalopathy Registry: rationale, methods, and initial results.","volume":"12","author":"Pfister","year":"2012","journal-title":"BMC Pediatr"},{"issue":"5","key":"2026012711213407600_B21","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/jp.2009.168","article-title":"Therapeutic hypothermia on neonatal transport: 4-year experience in a single NICU.","volume":"30","author":"Fairchild","year":"2010","journal-title":"J Perinatol"},{"issue":"6","key":"2026012711213407600_B22","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1111\/j.1651-2227.2009.01303.x","article-title":"Passive induction of hypothermia during transport of asphyxiated infants: a risk of excessive cooling.","volume":"98","author":"Hallberg","year":"2009","journal-title":"Acta Paediatr"},{"issue":"6","key":"2026012711213407600_B23","doi-asserted-by":"crossref","first-page":"F408","DOI":"10.1136\/adc.2010.187211","article-title":"Passive cooling for initiation of therapeutic hypothermia in neonatal encephalopathy.","volume":"95","author":"Kendall","year":"2010","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"5","key":"2026012711213407600_B24","doi-asserted-by":"crossref","first-page":"F365","DOI":"10.1136\/fetalneonatal-2011-211649","article-title":"Provision of servo-controlled cooling during neonatal transport.","volume":"97","author":"Johnston","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"5","key":"2026012711213407600_B25","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1542\/peds.2013-1686","article-title":"Active versus passive cooling during neonatal transport.","volume":"132","author":"Chaudhary","year":"2013","journal-title":"Pediatrics"},{"issue":"4","key":"2026012711213407600_B26","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1542\/peds.2012-0498","article-title":"Erythropoietin for neuroprotection in neonatal encephalopathy: safety and pharmacokinetics.","volume":"130","author":"Wu","year":"2012","journal-title":"Pediatrics"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/133\/6\/1146\/1702844\/peds_2014-0899.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/133\/6\/1146\/1702844\/peds_2014-0899.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T16:21:43Z","timestamp":1769530903000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/133\/6\/1146\/76110\/Hypothermia-and-Neonatal-Encephalopathy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,1]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,1]]},"published-print":{"date-parts":[[2014,6,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2014-0899","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,1]]}}}