{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:05:54Z","timestamp":1788930354796,"version":"build-2803163510"},"reference-count":35,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>To examine the survival of infants with hypoplastic left heart syndrome (HLHS) and potential influence of demographic and clinical characteristics on survival using population-based data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>Infants with nonsyndromic HLHS (n = 212) born between 1979 and 2005 were identified through the Metropolitan Atlanta Congenital Defects Program. Vital status was ascertained through 2009 based on linkage with vital records. We estimated Kaplan-Meier survival probabilities stratified by select demographic and clinical characteristics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>The overall survival probability to 2009 was 24% and significantly improved over time: from 0% in 1979\u20131984 to 42% in 1999\u20132005. Survival probability was 66% during the first week, 27% during the first year of life, and 24% during the first 10 years. Survival of very low and low birth weight or preterm infants and those born in high-poverty neighborhoods was significantly poorer. For children with information on surgical intervention (n = 88), the overall survival was 52%, and preterm infants had significantly poorer survival (31%) compared with term infants (56%). For children who survived to 1 year of age, long-term survival was \u223c90%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Survival to adolescence of children with nonsyndromic HLHS born in metropolitan Atlanta has significantly improved in recent years, with those born full term, with normal birth weight, or in a low-poverty neighborhood having a higher survival probability. Survival beyond infancy to adolescence is high. A better understanding of the growing population of survivors with HLHS is needed to inform resource planning.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2014-1427","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:20:37Z","timestamp":1442881237000},"page":"e864-e870","source":"Crossref","is-referenced-by-count":86,"title":["Survival of Children With Hypoplastic Left Heart Syndrome"],"prefix":"10.1542","volume":"136","author":[{"given":"Csaba","family":"Siffel","sequence":"first","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;"},{"name":"College of Allied Health Sciences, Georgia Regents University, Augusta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Riehle-Colarusso","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew E.","family":"Oster","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;"},{"name":"Children\u2019s Healthcare of Atlanta, Emory University, Atlanta, Georgia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Correa","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;"},{"name":"Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2015,10,1]]},"reference":[{"issue":"6","key":"2021120908430838800_B1","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.jpeds.2008.05.059","article-title":"Prevalence of congenital heart defects in metropolitan Atlanta, 1998\u20132005.","volume":"153","author":"Reller","year":"2008","journal-title":"J Pediatr"},{"issue":"9689","key":"2021120908430838800_B2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0140-6736(09)60563-8","article-title":"Hypoplastic left heart syndrome.","volume":"374","author":"Barron","year":"2009","journal-title":"Lancet"},{"issue":"9","key":"2021120908430838800_B3","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/bdra.10119","article-title":"First-year survival of infants born with congenital heart defects in Arkansas (1993\u20131998): a survival analysis using registry 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