{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:26:58Z","timestamp":1771468018199,"version":"3.50.1"},"reference-count":11,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:p>Recessive dystrophic epidermolysis bullosa (RDEB) is a devastating genodermatosis characterized by generalized skin fragility, severe blistering, and wounding that heals with mutilating scarring. Patients are in constant need of effective wound therapies as they often succumb to aggressive metastatic squamous cell carcinomas or to sepsis that may develop from their chronic wounds. Herein, we demonstrate accelerated wound healing with use of a fractionated CO2 laser protocol in a 22-year-old man with RDEB. His 9-month-old, non-healing wound decreased from 7 cm in diameter to 2 cm in diameter (a 92% reduction in wound surface area) within 4 weeks of a single laser treatment, and he had near-complete re-epithelialization within 4 weeks of his second laser treatment without blistering or other adverse effects. This novel intervention of using fractionated CO2 for photo-microdebridement could help revolutionize wound care for patients who have RDEB and whose chronic wounds serve as one of their greatest sources of morbidity and mortality. Dissemination to a pediatric audience is critical so that laser protocols might be more thoroughly investigated and incorporated into wound management strategies for this uniquely vulnerable population.<\/jats:p>","DOI":"10.1542\/peds.2014-1779","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T04:03:17Z","timestamp":1419307397000},"page":"e207-e210","source":"Crossref","is-referenced-by-count":17,"title":["Case Report: Rapidly Healing Epidermolysis Bullosa Wound After Ablative Fractional Resurfacing"],"prefix":"10.1542","volume":"135","author":[{"given":"Andrew C.","family":"Krakowski","sequence":"first","affiliation":[{"name":"University of California, San Diego, La Jolla, California;"},{"name":"Rady Children\u2019s Hospital, San Diego, California; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedram","family":"Ghasri","sequence":"additional","affiliation":[{"name":"University of California, Irvine, Irvine, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"issue":"11","key":"2021120907222963300_B1","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1001\/2013.jamadermatol.256","article-title":"Rapid healing of scar-associated chronic wounds after ablative fractional resurfacing.","volume":"148","author":"Shumaker","year":"2012","journal-title":"Arch Dermatol"},{"key":"2021120907222963300_B2"},{"issue":"4","key":"2021120907222963300_B3","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/01.ico.0000151722.84634.bf","article-title":"Ocular surface findings in Hallopeau-Siemens subtype of dystrophic epidermolysis bullosa: report of a case and literature 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of treatments for inherited forms of epidermolysis bullosa.","volume":"34","author":"Langan","year":"2009","journal-title":"Clin Exp Dermatol"},{"issue":"5","key":"2021120907222963300_B8","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/lsm.20048","article-title":"Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury.","volume":"34","author":"Manstein","year":"2004","journal-title":"Lasers Surg Med"},{"issue":"6","key":"2021120907222963300_B9","doi-asserted-by":"crossref","first-page":"064044","DOI":"10.1117\/1.3275479","article-title":"Immunohistochemical investigation of wound healing in response to fractional photothermolysis.","volume":"14","author":"Helbig","year":"2009","journal-title":"J Biomed Opt"},{"issue":"1","key":"2021120907222963300_B10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1524-475X.2007.00321.x","article-title":"Biofilms in chronic wounds.","volume":"16","author":"James","year":"2008","journal-title":"Wound Repair Regen"},{"issue":"2","key":"2021120907222963300_B11","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jaad.2010.01.047","article-title":"The efficacy of trimethoprim in wound healing of patients with epidermolysis bullosa: a feasibility trial.","volume":"66","author":"Lara-Corrales","year":"2012","journal-title":"J Am Acad Dermatol"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/135\/1\/e207\/900707\/peds_2014-1779.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/135\/1\/e207\/900707\/peds_2014-1779.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T01:59:31Z","timestamp":1639101571000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/135\/1\/e207\/52879\/Case-Report-Rapidly-Healing-Epidermolysis-Bullosa"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,1]]},"published-print":{"date-parts":[[2015,1,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2014-1779","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,1]]}}}