{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:36:15Z","timestamp":1792632975750,"version":"4.5.0"},"reference-count":24,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:p>Naegleria fowleri is a thermophilic, free-living ameba that causes primary amebic meningoencephalitis. The infections are nearly always fatal. We present the third well-documented survivor of this infection in North America. The patient\u2019s survival most likely resulted from a variety of factors: early identification and treatment, use of a combination of antimicrobial agents (including miltefosine), and management of elevated intracranial pressure based on the principles of traumatic brain injury.<\/jats:p>","DOI":"10.1542\/peds.2014-2292","type":"journal-article","created":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T23:54:10Z","timestamp":1423526050000},"page":"e744-e748","source":"Crossref","is-referenced-by-count":149,"title":["Successful Treatment of an Adolescent With\n                    <i>Naegleria fowleri<\/i>\n                    Primary Amebic Meningoencephalitis"],"prefix":"10.1542","volume":"135","author":[{"given":"W. Matthew","family":"Linam","sequence":"first","affiliation":[{"name":"Pediatric Infectious Diseases Section and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mubbasheer","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Section, Arkansas Children's Hospital, Little Rock, Arkansas; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer R.","family":"Cope","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Chu","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Section, Arkansas Children's Hospital, Little Rock, Arkansas; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govinda S.","family":"Visvesvara","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre J.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Qvarnstrom","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerril","family":"Green","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Section, Arkansas Children's Hospital, Little Rock, Arkansas; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2015,3,1]]},"reference":[{"issue":"6","key":"2021121016270447800_B1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1056\/NEJM198202113060607","article-title":"Successful treatment of primary amebic meningoencephalitis.","volume":"306","author":"Seidel","year":"1982","journal-title":"N Engl J Med"},{"issue":"1","key":"2021121016270447800_B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-695X.2007.00232.x","article-title":"Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp, Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea.","volume":"50","author":"Visvesvara","year":"2007","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"1","key":"2021121016270447800_B3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.arcmed.2004.11.003","article-title":"Successful treatment of Naegleria fowleri meningoencephalitis by using intravenous amphotericin B, fluconazole and rifampicin.","volume":"36","author":"Vargas-Zepeda","year":"2005","journal-title":"Arch Med Res"},{"issue":"33","key":"2021121016270447800_B4","first-page":"666","article-title":"Investigational drug available directly from CDC for the treatment of infections with free-living amebae.","volume":"62","author":"Centers for Disease Control and Prevention (CDC)","year":"2013","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"7","key":"2021121016270447800_B5","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1017\/S0950268809991014","article-title":"The epidemiology of primary amoebic meningoencephalitis in the USA, 1962-2008.","volume":"138","author":"Yoder","year":"2010","journal-title":"Epidemiol Infect"},{"key":"2021121016270447800_B6","unstructured":"Centers for Disease Control and Prevention (CDC). Naegleria fowleri\u2014primary amebic meningoencephalitis (PAM). Available at: www.cdc.gov\/parasites\/naegleria\/infection-sources.html. 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