{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:49:25Z","timestamp":1793411365884,"version":"4.5.0"},"reference-count":61,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVES:<\/jats:title>\n                  <jats:p>To examine the relationship of cardiac biomarkers with postoperative acute kidney injury (AKI) among pediatric patients undergoing cardiac surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>Data from TRIBE-AKI, a prospective study of children undergoing cardiac surgery, were used to examine the association of cardiac biomarkers (N-type pro\u2013B-type natriuretic peptide, creatine kinase-MB [CK-MB], heart-type fatty acid binding protein [h-FABP], and troponins I and T) with the development of postoperative AKI. Cardiac biomarkers were collected before and 0 to 6 hours after surgery. AKI was defined as a \u226550% or 0.3 mg\/dL increase in serum creatinine, within 7 days of surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Of the 106 patients included in this study, 55 (52%) developed AKI after cardiac surgery. Patients who developed AKI had higher median levels of pre- and postoperative cardiac biomarkers compared with patients without AKI (all P &amp;lt; .01). Preoperatively, higher levels of CK-MB and h-FABP were associated with increased odds of developing AKI (CK-MB: adjusted odds ratio 4.58, 95% confidence interval [CI] 1.56\u201313.41; h-FABP: adjusted odds ratio 2.76, 95% CI 1.27\u20136.03). When combined with clinical models, both preoperative CK-MB and h-FABP provided good discrimination (area under the curve 0.77, 95% CI 0.68\u20130.87, and 0.78, 95% CI 0.68\u20130.87, respectively) and improved reclassification indices. Cardiac biomarkers collected postoperatively did not significantly improve the prediction of AKI beyond clinical models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Preoperative CK-MB and h-FABP are associated with increased risk of postoperative AKI and provide good discrimination of patients who develop AKI. These biomarkers may be useful for risk stratifying patients undergoing cardiac surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2014-2949","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T00:32:23Z","timestamp":1425947543000},"page":"e945-e956","source":"Crossref","is-referenced-by-count":53,"title":["Cardiac Biomarkers and Acute Kidney Injury After Cardiac Surgery"],"prefix":"10.1542","volume":"135","author":[{"given":"Emily M.","family":"Bucholz","sequence":"first","affiliation":[{"name":"School of Medicine, and"},{"name":"Department of Chronic Disease Epidemiology, School of Public Health, Yale University, New Haven, Connecticut;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Whitlock","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Population Health Research Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Zappitelli","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics, Montreal Children\u2019s Hospital, McGill University Health Centre, Montreal, Quebec, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad","family":"Devarajan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Eikelboom","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Population Health Research Institute, and"},{"name":"Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit X.","family":"Garg","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, and"},{"name":"Department of Epidemiology and Biostatistics, University of Western Ontario, London, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather Thiessen","family":"Philbrook","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Devereaux","sequence":"additional","affiliation":[{"name":"Departments of Clinical Epidemiology and Biostatistics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine D.","family":"Krawczeski","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Lucile Packard Children\u2019s Hospital, Stanford University School of Medicine, Palo Alto, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kavsak","sequence":"additional","affiliation":[{"name":"Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Shortt","sequence":"additional","affiliation":[{"name":"Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirag R.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,"},{"name":"Clinical Epidemiology Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the TRIBE-AKI Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2015,4,1]]},"reference":[{"issue":"5","key":"2021120907074797000_B1","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.athoracsur.2012.06.050","article-title":"Acute kidney injury after surgery for congenital heart 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