{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:40:11Z","timestamp":1790206811274,"version":"4.1.0"},"reference-count":9,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND AND OBJECTIVES:<\/jats:title>\n                  <jats:p>Infant mortality is an indicator of overall societal health, and a significant proportion of infant deaths occur in NICUs. The objectives were to identify causes of death and to define potentially preventable factors associated with death as areas for quality improvement efforts in the NICU.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>In a prospectively defined study, the principal investigator in 46 level III NICUs agreed to review health care records of infants who died. For each infant, the principal investigator reviewed the medical record to identify the primary cause of death and to look for preventable factors associated with the infant\u2019s death. Infants born at \u226522 weeks estimated gestational age who were born alive were included. Stillborn infants were excluded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Data were collected on 641 infants who died. At lower gestational ages, mortality was most commonly due to extreme prematurity and the complications of premature birth (respiratory distress progressing to respiratory failure, intraventricular hemorrhage, necrotizing enterocolitis, and sepsis). With increasing gestational age, the etiology of mortality shifted to hypoxic\u2013ischemic encephalopathy and genetic or structural anomalies. Reviewers of clinical care identified 197 (31%) infants with potentially modifiable factors that may have contributed to their deaths.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>The factors associated with death in infants admitted for intensive care are multifactorial and diverse, and they change with gestational age. In 31% of the deaths, potentially modifiable factors were identified, and these factors suggest important targets for reducing infant mortality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2014-2967","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T02:18:13Z","timestamp":1418091493000},"page":"e59-e65","source":"Crossref","is-referenced-by-count":103,"title":["Etiologies of NICU Deaths"],"prefix":"10.1542","volume":"135","author":[{"given":"Jack","family":"Jacob","sequence":"first","affiliation":[{"name":"Pediatrix Medical Group, Center for Research and Education, Sunrise, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kamitsuka","sequence":"additional","affiliation":[{"name":"Pediatrix Medical Group, Center for Research and Education, Sunrise, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reese H.","family":"Clark","sequence":"additional","affiliation":[{"name":"Pediatrix Medical Group, Center for Research and Education, Sunrise, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy S.","family":"Kelleher","sequence":"additional","affiliation":[{"name":"Pediatrix Medical Group, Center for Research and Education, Sunrise, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Spitzer","sequence":"additional","affiliation":[{"name":"Pediatrix Medical Group, Center for Research and Education, Sunrise, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"issue":"31","key":"2021120907200136500_B1","first-page":"625","article-title":"CDC Grand Rounds: public health approaches to reducing U.S. infant mortality.","volume":"62","author":"Grand Rounds","year":"2013","journal-title":"MMWR Morb Mortal Wkly 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infants.","volume":"132","author":"Alleman","year":"2013","journal-title":"Pediatrics"},{"key":"2021120907200136500_B8"},{"issue":"1","key":"2021120907200136500_B9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1542\/peds.2011-1037","article-title":"Standard terminology for fetal, infant, and perinatal deaths.","volume":"128","author":"Barfield","year":"2011","journal-title":"Pediatrics"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/135\/1\/e59\/902259\/peds_2014-2967.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/135\/1\/e59\/902259\/peds_2014-2967.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T01:57:36Z","timestamp":1639101456000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/135\/1\/e59\/52821\/Etiologies-of-NICU-Deaths"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,1]]},"published-print":{"date-parts":[[2015,1,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2014-2967","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,1]]}}}