{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:03:58Z","timestamp":1763705038188,"version":"3.40.5"},"reference-count":11,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,1]]},"abstract":"<jats:p>We report on a term neonate with unexplained respiratory distress, dilatation of the descending aorta, and low serum retinol concentration. The respiratory distress did not respond to conventional medical management and persisted for 22 days requiring an inspired oxygen fraction of 0.4 to 0.5 to maintain adequate arterial oxygen saturation. One week after intramuscular vitamin A therapy, the respiratory distress and requirement for supplementary oxygen resolved. Dilatation of the distal aorta resolved at 7 weeks of age. An association between vitamin A deficiency and aortic dilatation has previously been described in rats, but the association in humans has rarely been reported. We suggest that unexplained neonatal respiratory distress and a dilated aorta should prompt suspicion of vitamin A deficiency. An underlying infective or inflammatory process may give rise to a falsely low serum retinol concentration. Serum retinol and retinol binding protein concentrations in both the mother and infant should be used to guide vitamin A status, treatment, and subsequent response.<\/jats:p>","DOI":"10.1542\/peds.2014-3028","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T00:32:43Z","timestamp":1430181163000},"page":"e1321-e1325","source":"Crossref","is-referenced-by-count":4,"title":["Neonatal Aortic Dilatation Secondary to Vitamin A Deficiency"],"prefix":"10.1542","volume":"135","author":[{"given":"Rephainah","family":"Mallett","sequence":"first","affiliation":[{"name":"Southampton General Hospital, Hampshire, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanique","family":"Simmonds","sequence":"additional","affiliation":[{"name":"Kings College London, Strand, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abirami","family":"Kuppurajan","sequence":"additional","affiliation":[{"name":"Women\u2019s Center Hospitals, Coimbatore, India; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arul","family":"Narayanan","sequence":"additional","affiliation":[{"name":"Narayana Hrudayalaya Hospital, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karthik","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Women\u2019s Center Hospitals, Coimbatore, India; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santhanakrishnan","family":"Ramakrishnan","sequence":"additional","affiliation":[{"name":"Women\u2019s Center Hospitals, Coimbatore, India; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2015,5,1]]},"reference":[{"issue":"12","key":"2021120907100403000_B1","doi-asserted-by":"crossref","first-page":"e530","DOI":"10.1111\/apa.12009","article-title":"Neonatal aortic dilatation associated with vitamin A deficiency and its subsequent remission after supplementation therapy.","volume":"101","author":"Cabano","year":"2012","journal-title":"Acta Paediatr"},{"issue":"2","key":"2021120907100403000_B2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4103\/0974-2069.99622","article-title":"The use of Z-scores in paediatric cardiology.","volume":"5","author":"Chubb","year":"2012","journal-title":"Ann Pediatr Cardiol"},{"issue":"8","key":"2021120907100403000_B3","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.echo.2008.02.006","article-title":"Regression equations for calculation of z scores of cardiac structures in a large cohort of healthy infants, children, and adolescents: an echocardiographic study.","volume":"21","author":"Pettersen","year":"2008","journal-title":"J Am Soc Echocardiogr"},{"unstructured":"World Health Organization. Global prevalence of vitamin A deficiency in populations at risk 1995-2005. Available at: www.who.int\/vmnis\/vitamina\/prevalence\/en\/. Accessed September 13, 2014","key":"2021120907100403000_B4"},{"issue":"6","key":"2021120907100403000_B5","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1080\/10715760500072214","article-title":"Vitamin A deficiency induces prooxidant environment and inflammation in rat aorta.","volume":"39","author":"Gatica","year":"2005","journal-title":"Free Radic Res"},{"issue":"6","key":"2021120907100403000_B6","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1159\/000096247","article-title":"Alterations in the lipid metabolism of rat aorta: effects of vitamin a deficiency.","volume":"43","author":"Gatica","year":"2006","journal-title":"J Vasc Res"},{"issue":"1","key":"2021120907100403000_B7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00394-011-0198-z","article-title":"Implication of vitamin A deficiency on vascular injury related to inflammation and oxidative stress: effects on the ultrastructure of rat aorta.","volume":"51","author":"Gatica","year":"2012","journal-title":"Eur J Nutr"},{"doi-asserted-by":"crossref","unstructured":"Underwood BA. Maternal vitamin A status and its importance in infancy and early childhood. Am J Clin Nutr. 1994;59(2 suppl):517S\u2013522S; discussion 522S\u2013524S","key":"2021120907100403000_B8","DOI":"10.1093\/ajcn\/59.2.517S"},{"issue":"11","key":"2021120907100403000_B9","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1093\/clinchem\/48.11.2061","article-title":"Bias and random error in retinol measurements of laboratories in countries with populations with mild to severe vitamin A deficiency.","volume":"48","author":"Hulshof","year":"2002","journal-title":"Clin Chem"},{"issue":"11","key":"2021120907100403000_B10","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1631\/jzus.2005.B1045","article-title":"Acute phase reaction and acute phase proteins.","volume":"6","author":"Gruys","year":"2005","journal-title":"J Zhejiang Univ Sci B"},{"issue":"5","key":"2021120907100403000_B11","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1093\/ajcn\/72.5.1170","article-title":"Serum retinol, the acute phase response, and the apparent misclassification of vitamin A status in the third National Health and Nutrition Examination Survey.","volume":"72","author":"Stephensen","year":"2000","journal-title":"Am J Clin Nutr"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/135\/5\/e1321\/1093281\/peds_2014-3028.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/135\/5\/e1321\/1093281\/peds_2014-3028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T01:37:52Z","timestamp":1639100272000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/135\/5\/e1321\/33646\/Neonatal-Aortic-Dilatation-Secondary-to-Vitamin-A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,1]]},"references-count":11,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,1]]},"published-print":{"date-parts":[[2015,5,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2014-3028","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"type":"print","value":"0031-4005"},{"type":"electronic","value":"1098-4275"}],"subject":[],"published":{"date-parts":[[2015,5,1]]}}}