{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:06:05Z","timestamp":1785416765520,"version":"3.56.0"},"reference-count":13,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,1]]},"abstract":"<jats:p>The melanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm that primarily affects the maxilla of infants during their first year of life. Complete resection is the conventional treatment and recurrence rates vary from 10% to 60%. The recurrent tumors grow more aggressively and can invade other anatomic structures, such as the nasal cavity, the orbit, and the skull base. The aggressive behavior of MNTIs may require radical resection, which may not be possible in some cases because of its rapid and invading growth together with invasion of vital structures. In these situations, adjunct radiotherapy or chemotherapy has been used. However, as there are no conclusive data regarding the molecular profile of this tumor, currently there is no targeted therapy that may be used in the treatment of selected aggressive cases. On the basis of MNTI similarities with melanomas, such as derivation from the neural crest cells and presence of large melanin-containing cells, we hypothesized that MNTIs also may harbor the BRAFV600E oncogenic mutation. We show for the first time that this important pediatric tumor may harbor the oncogenic BRAFV600E mutation, providing the first insights to their personalized treatment.<\/jats:p>","DOI":"10.1542\/peds.2014-3331","type":"journal-article","created":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T00:20:16Z","timestamp":1435623616000},"page":"e267-e269","source":"Crossref","is-referenced-by-count":35,"title":["BRAFV600E Mutation in Melanotic Neuroectodermal Tumor of Infancy: Toward Personalized Medicine?"],"prefix":"10.1542","volume":"136","author":[{"given":"Carolina C.","family":"Gomes","sequence":"first","affiliation":[{"name":"Department of Pathology, Biological Sciences Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina G.","family":"Diniz","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazielle Helena F.","family":"de Menezes","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner H.","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo S.","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2015,7,1]]},"reference":[{"key":"2021120820571672500_B1","volume-title":"Oral and Maxillofacial Pathology","author":"Neville","year":"2009","edition":"3rd ed."},{"issue":"2","key":"2021120820571672500_B2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.tripleo.2005.08.010","article-title":"Melanotic neuroectodermal tumor of infancy: systematic review of the literature and presentation of a case.","volume":"102","author":"Kruse-L\u00f6sler","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"9","key":"2021120820571672500_B3","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1016\/j.joms.2009.03.059","article-title":"Melanotic neuroectodermal tumor of infancy: report of 2 cases.","volume":"68","author":"Gon\u00e7alves","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"issue":"4","key":"2021120820571672500_B4","doi-asserted-by":"crossref","first-page":"e338","DOI":"10.1097\/SCS.0b013e31828a7c4c","article-title":"Maxillary melanotic neuroectodermal tumor of infancy management: is conservative surgery the best approach?","volume":"24","author":"B\u00e9ogo","year":"2013","journal-title":"J Craniofac Surg"},{"issue":"15","key":"2021120820571672500_B5","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1016\/j.febslet.2014.06.025","article-title":"\u201cRAF\u201d neighborhood: protein-protein interaction in the Raf\/Mek\/Erk pathway.","volume":"588","author":"Cseh","year":"2014","journal-title":"FEBS Lett"},{"issue":"3","key":"2021120820571672500_B6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/107327481402100307","article-title":"BRAF mutations: signaling, epidemiology, and clinical experience in multiple malignancies.","volume":"21","author":"Hall","year":"2014","journal-title":"Cancer Contr"},{"issue":"9","key":"2021120820571672500_B7","doi-asserted-by":"crossref","first-page":"e371","DOI":"10.1016\/S1470-2045(14)70072-5","article-title":"Systemic treatment for BRAF-mutant melanoma: where do we go next?","volume":"15","author":"Menzies","year":"2014","journal-title":"Lancet Oncol"},{"issue":"1","key":"2021120820571672500_B8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3171\/jns.1995.83.1.0145","article-title":"Melanotic neuroectodermal tumor of infancy: a molecular approach to diagnosis. 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