{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:16:54Z","timestamp":1792819014962,"version":"4.5.0"},"reference-count":33,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,8,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND:<\/jats:title>\n                  <jats:p>Thrombocytopenia is common among small-for-gestational-age (SGA) neonates (birth weight &amp;lt;10th percentile reference range), but several aspects of this thrombocytopenia are unclear, including the incidence, typical nadir, duration, association with preeclampsia, mechanism, and risk of death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>Using 9 years of multihospital records, we studied SGA neonates with \u22652 platelet counts &amp;lt;150\u2009000\/\u03bcL in their first week.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>We found first-week thrombocytopenia in 31% (905 of 2891) of SGA neonates versus 10% of non-SGA matched controls (P &amp;lt; .0001). Of the 905, 102 had a recognized cause of thrombocytopenia (disseminated intravascular coagulation, early-onset sepsis, or extracorporeal membrane oxygenation). This group had a 65% mortality rate. The remaining 803 did not have an obvious cause for their thrombocytopenia, and we called this \u201cthrombocytopenia of SGA.\u201d They had a mortality rate of 2% (P &amp;lt; .0001) and a mean nadir count on day 4 of 93\u2009000\/\u03bcL (SD 51\u2009580\/\u03bcL, 10th percentile 50\u2009000\/\u03bcL, 90th percentile 175\u2009000\/\u03bcL). By day 14, platelet counts were \u2265150\u2009000\/\u03bcL in more than half of the patients. Severely SGA neonates (&amp;lt;1st percentile) had lower counts and longer thrombocytopenia duration (P &amp;lt; .001). High nucleated red cell counts at birth correlated with low platelets (P &amp;lt; .0001). Platelet transfusions were given to 23%, and counts typically more than tripled. Thrombocytopenia was more associated with SGA status than with the diagnosis of maternal preeclampsia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>SGA neonates with clearly recognized varieties of thrombocytopenia have a high mortality rate. In contrast, thrombocytopenia of SGA is a hyporegenerative condition of moderate severity and 2 weeks\u2019 duration and is associated with evidence of intrauterine hypoxia and a low mortality rate.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2014-4182","type":"journal-article","created":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T00:19:27Z","timestamp":1438042767000},"page":"e361-e370","source":"Crossref","is-referenced-by-count":45,"title":["Thrombocytopenia in Small-for-Gestational-Age Infants"],"prefix":"10.1542","volume":"136","author":[{"given":"Robert D.","family":"Christensen","sequence":"first","affiliation":[{"name":"Divisions of Hematology\/Oncology, and"},{"name":"Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah;"},{"name":"Primary Children\u2019s Hospital, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie L.","family":"Baer","sequence":"additional","affiliation":[{"name":"Women and Newborn\u2019s Clinical Program, Intermountain Healthcare, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Henry","sequence":"additional","affiliation":[{"name":"Primary Children\u2019s Hospital, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory L.","family":"Snow","sequence":"additional","affiliation":[{"name":"Statistical Data Center, LDS Hospital, Salt Lake City, Utah; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Butler","sequence":"additional","affiliation":[{"name":"Statistical Data Center, LDS Hospital, Salt Lake City, Utah; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha C.","family":"Sola-Visner","sequence":"additional","affiliation":[{"name":"Division of Neonatal Medicine, Children\u2019s Hospital and Harvard Medical School, 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