{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:11:44Z","timestamp":1757779904024,"version":"3.41.2"},"reference-count":16,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2,1]]},"abstract":"<jats:p>Previous studies have shown that thyroid hormone directly stimulates bone resorption in in vitro organ culture, and in adults excess thyroid hormone is associated with decreased bone mineral density. There are limited data in children regarding the effect of hyperthyroidism on bone metabolism and even fewer instances in the literature of hyperthyroidism presenting with bone demineralization and fracture. We report a case of an 11-year-old boy with undiagnosed hyperthyroidism presenting with fractures and osteoporosis. This case emphasizes the importance of maintaining a broad differential diagnosis when a patient presents with a pathologic fracture.<\/jats:p>","DOI":"10.1542\/peds.2015-0169","type":"journal-article","created":{"date-parts":[[2016,1,9]],"date-time":"2016-01-09T02:39:08Z","timestamp":1452307148000},"source":"Crossref","is-referenced-by-count":6,"title":["Hyperthyroidism Presenting With Pathologic Fractures"],"prefix":"10.1542","volume":"137","author":[{"given":"Margaret D.","family":"Sarezky","sequence":"first","affiliation":[{"name":"Department of Pediatrics,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Corwin","sequence":"additional","affiliation":[{"name":"Divisions of Emergency Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor S.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Endocrinology, The Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania; 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