{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:41:28Z","timestamp":1793115688755,"version":"4.5.0"},"reference-count":73,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>Understanding how young girls respond to growing up with breast cancer family histories is critical given expansion of genetic testing and breast cancer messaging. We examined the impact of breast cancer family history on psychosocial adjustment and health behaviors among &amp;gt;800 girls in the multicenter LEGACY Girls Study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>Girls aged 6 to 13 years with a family history of breast cancer or familial BRCA1\/2 mutation (BCFH+), peers without a family history (BCFH\u2013), and their biological mothers completed assessments of psychosocial adjustment (maternal report for 6- to 13-year-olds, self-report for 10- to 13-year-olds), breast cancer\u2013specific distress, perceived risk of breast cancer, and health behaviors (10- to 13-year-olds).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>BCFH+ girls had better general psychosocial adjustment than BCFH\u2013 peers by maternal report. Psychosocial adjustment and health behaviors did not differ significantly by self-report among 10- to 13-year-old girls. BCFH+ girls reported higher breast cancer\u2013specific distress (P = .001) and were more likely to report themselves at increased breast cancer risk than BCFH\u2013 peers (38.4% vs 13.7%, P &amp;lt; .001), although many girls were unsure of their risk. In multivariable analyses, higher daughter anxiety was associated with higher maternal anxiety and poorer family communication. Higher daughter breast cancer\u2013specific distress was associated with higher maternal breast cancer-specific distress.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Although growing up in a family at risk for breast cancer does not negatively affect general psychosocial adjustment among preadolescent girls, those from breast cancer risk families experience greater breast cancer\u2013specific distress. Interventions to address daughter and mother breast cancer concerns and responses to genetic or familial risk might improve psychosocial outcomes of teen daughters.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2015-0498","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T12:06:16Z","timestamp":1445342776000},"page":"927-937","source":"Crossref","is-referenced-by-count":18,"title":["Psychosocial Adjustment in School-age Girls With a Family History of Breast Cancer"],"prefix":"10.1542","volume":"136","author":[{"given":"Angela R.","family":"Bradbury","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, and"},{"name":"Department of Medical Ethics and Health Policy, The Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Patrick-Miller","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, and the Center for Clinical Cancer Genetics and Global Health, The University of Chicago, Chicago, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Oncology, The Children\u2019s Hospital of Philadelphia and Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Egleston","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics Facility, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen Burke","family":"Sands","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy K.","family":"Chung","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gord","family":"Glendon","sequence":"additional","affiliation":[{"name":"Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine A.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Mailman School of Public Health, Columbia University Medical Center, New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Massachusetts General Hospital, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Rauch","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Massachusetts General Hospital, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Tuchman","sequence":"additional","affiliation":[{"name":"Department of Adolescent Medicine, Children\u2019s National Medical Center, Washington, District of Columbia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene L.","family":"Andrulis","sequence":"additional","affiliation":[{"name":"Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada;"},{"name":"Departments of Molecular Genetics and Laboratory Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saundra S.","family":"Buys","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Oncology, The University of Utah Health Sciences Center, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caren J.","family":"Frost","sequence":"additional","affiliation":[{"name":"College of Social Work, The University of Utah, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa H.M.","family":"Keegan","sequence":"additional","affiliation":[{"name":"Cancer Prevention Institute of California, Fremont, California; 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