{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:46:04Z","timestamp":1770975964876,"version":"3.50.1"},"reference-count":13,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:p>Immobility-induced hypercalcemia is a rare cause of hypercalcemia in children, and to our knowledge it has never been reported in an infant. Infants and children are in a state of high bone turnover. Therefore, they are prone to the imbalance of osteoblastic and osteoclastic activity that occurs with prolonged immobilization, leading to hypercalcemia. Here we present the case of an infant with hypercalcemia who presented with fatigue, irritability, and failure to thrive after prolonged immobilization. Therapeutic interventions were conservative and included hydration and increased mobility leading to complete resolution. This case highlights the importance of including this rare entity in a differential diagnosis of hypercalcemia as well as screening postsurgical patients with prolonged immobility for hypercalcemia.<\/jats:p>","DOI":"10.1542\/peds.2015-0879","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T12:12:23Z","timestamp":1458303143000},"source":"Crossref","is-referenced-by-count":6,"title":["A Rare Case Report of Immobility-Induced Hypercalcemia in an Infant"],"prefix":"10.1542","volume":"137","author":[{"given":"Neha","family":"Vyas","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Rainbow Babies and Children\u2019s Hospital , Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth","family":"Kaminski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Rainbow Babies and Children\u2019s Hospital , Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"MacLeish","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Rainbow Babies and Children\u2019s Hospital , Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2016,4,1]]},"reference":[{"issue":"9","key":"2021121021241924300_B1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1210\/jcem-1-9-711","article-title":"Acute atrophy of bone (osteoporosis) simulating hyperparathyroidism.","volume":"1","author":"Albright","year":"1941","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2021121021241924300_B2","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/MOP.0b013e32833b7c23","article-title":"Hypercalcemia in children and adolescents.","volume":"22","author":"Lietman","year":"2010","journal-title":"Curr Opin Pediatr"},{"issue":"781","key":"2021121021241924300_B3","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1136\/pgmj.66.781.918","article-title":"Immobilization-related hypercalcaemia\u2014a possible novel mechanism and response to pamidronate.","volume":"66","author":"Gallacher","year":"1990","journal-title":"Postgrad Med J"},{"issue":"11","key":"2021121021241924300_B4","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1136\/jnnp.47.11.1232","article-title":"Immobilisation hypercalcaemia complicating polyneuropathy in adolescent boys.","volume":"47","author":"Walls","year":"1984","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"6","key":"2021121021241924300_B5","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s004670050654","article-title":"Hypercalcemia of the newborn: etiology, evaluation, and management.","volume":"13","author":"Rodd","year":"1999","journal-title":"Pediatr Nephrol"},{"issue":"11","key":"2021121021241924300_B6","doi-asserted-by":"crossref","first-page":"6316","DOI":"10.1210\/jc.2005-0675","article-title":"Clinical review: rare causes of hypercalcemia.","volume":"90","author":"Jacobs","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2021121021241924300_B7","first-page":"277","article-title":"Severe neonatal hypercalcemia due to primary hyperparathyroidism: a case report.","volume":"18","author":"Shiva","year":"2008","journal-title":"Iran J Pediatr"},{"issue":"4","key":"2021121021241924300_B8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/01.smj.0000210142.76331.b4","article-title":"An unrecognized cause of recurrent hypercalcemia: immobilization.","volume":"99","author":"Cheng","year":"2006","journal-title":"South Med J"},{"issue":"12","key":"2021121021241924300_B9","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1210\/jc.2013-1811","article-title":"Acute severe hypercalcemia after traumatic fractures and immobilization in hypophosphatasia complicated by chronic renal failure.","volume":"98","author":"Whyte","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"19","key":"2021121021241924300_B10","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJM198205133061903","article-title":"Calcium homeostasis in immobilization: an example of resorptive hypercalciuria.","volume":"306","author":"Stewart","year":"1982","journal-title":"N Engl J Med"},{"issue":"2","key":"2021121021241924300_B11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1046\/j.1440-1754.2003.00083.x","article-title":"Use of bisphosphonate therapy for osteoporosis in childhood and adolescence.","volume":"39","author":"Batch","year":"2003","journal-title":"J Paediatr Child Health"},{"issue":"3","key":"2021121021241924300_B12","doi-asserted-by":"crossref","first-page":"e812","DOI":"10.1542\/peds.2011-0128","article-title":"Successful use of bisphosphonate and calcimimetic in neonatal severe primary hyperparathyroidism.","volume":"129","author":"Wilhelm-Bals","year":"2012","journal-title":"Pediatrics"},{"issue":"5","key":"2021121021241924300_B13","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000365889","article-title":"The use of bisphosphonates in pediatrics.","volume":"82","author":"Baroncelli","year":"2014","journal-title":"Horm Res Paediatr"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2015-0879\/1093288\/peds_20150879.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2015-0879\/1093288\/peds_20150879.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T06:57:22Z","timestamp":1639205842000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/137\/4\/e20150879\/81361\/A-Rare-Case-Report-of-Immobility-Induced"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,1]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4,1]]},"published-print":{"date-parts":[[2016,4,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2015-0879","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,1]]},"article-number":"e20150879"}}