{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:26:27Z","timestamp":1788251187903,"version":"build-2803163510"},"reference-count":17,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12,1]]},"abstract":"<jats:p>Trichodysplasia spinulosa (TS) is a rare entity, characterized by a follicular digitate keratosis predominantly affecting the face and variable degrees of hair loss, most severely facial hair, that occurs in immunosuppressed individuals, and is considered to be a viral infection caused by a human polyomavirus, the \u201cTS-associated polyomavirus.\u201d Histologically it is characterized by hair follicles with excessive inner root-sheath differentiation and intraepithelial viral inclusions. Correlation of these findings with clinical features is required for diagnosis. Treatment with antiviral agents appears to be the most effective. We report the occurrence of TS in a 20-month-old girl with multivisceral transplantation due to short-bowel syndrome secondary to intestinal atresia and gastroschisis. The patient was treated with cidofovir 1% cream, with significant improvement and without any adverse effects. We describe the youngest patient, to our knowledge, with TS.<\/jats:p>","DOI":"10.1542\/peds.2015-0953","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T02:14:19Z","timestamp":1448936059000},"page":"e1646-e1649","source":"Crossref","is-referenced-by-count":14,"title":["Trichodysplasia Spinulosa in a 20-Month-Old Girl With a Good Response to Topical Cidofovir 1%"],"prefix":"10.1542","volume":"136","author":[{"given":"Raquel","family":"Santesteban","sequence":"first","affiliation":[{"name":"Department of Dermatology, Complejo Hospitalario de Navarra, Pamplona, Spain; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Feito","sequence":"additional","affiliation":[{"name":"Departments of Dermatology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ander","family":"Mayor","sequence":"additional","affiliation":[{"name":"Departments of 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