{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:12:05Z","timestamp":1787497925453,"version":"build-2736575974"},"reference-count":16,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:p>Significant advancements in the care of children with cardiac valve disease over the past 15 years have led to the increasingly common use of percutaneous transcatheter valve implantation as an alternative to surgical replacement in selected patient populations. Although the transcatheter approach has several advantages, this approach and the valves used are not without complications. Bacterial endocarditis is a known and concerning complication after transcatheter pulmonary valve replacement (TPVR). Most reported cases have involved organisms that are common etiologic agents of bacterial endocarditis and are readily identified via blood culture. However, culture-negative endocarditis in the setting of TPVR has not been well described. We present our experience with one afebrile teenager with culture-negative, serology-positive Bartonella henselae endocarditis of a Melody valve 18 months after TPVR for management of tetralogy of Fallot. The teen was successfully managed with long-term antibiotic therapy followed by surgical replacement of the valve. To our knowledge, this is the first reported case of culture-negative endocarditis of a Melody TPVR in the absence of fever. This report discusses the importance of considering culture-negative endocarditis in the differential diagnosis of an afebrile patient with TPVR presenting with constitutional symptoms and valve dysfunction, particularly in the primary care setting. It is anticipated that with an increase in the successfully aging population of children who have undergone cardiac repair, the evaluation of these patients will become an increasingly important and common task for the community pediatrician.<\/jats:p>","DOI":"10.1542\/peds.2015-1548","type":"journal-article","created":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T21:09:21Z","timestamp":1449868161000},"source":"Crossref","is-referenced-by-count":9,"title":["Melody Valve\n                    <i>Bartonella henselae<\/i>\n                    Endocarditis in an Afebrile Teen: A Case Report"],"prefix":"10.1542","volume":"137","author":[{"given":"Tina","family":"Sosa","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Cnota","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roosevelt","family":"Bryant","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiac Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Frenck","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Washam","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2016,1,1]]},"reference":[{"issue":"2","key":"2021120907215454400_B1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/ccd.25375","article-title":"Melody pulmonary valve bacterial endocarditis: experience in four pediatric patients and a review of the literature.","volume":"84","author":"Villafa\u00f1e","year":"2014","journal-title":"Catheter Cardiovasc Interv"},{"issue":"1","key":"2021120907215454400_B2","first-page":"94","article-title":"Bartonella henselae endocarditis of percutaneously implanted pulmonary valve: a case report.","volume":"20","author":"Atamanyuk","year":"2011","journal-title":"J Heart Valve Dis"},{"issue":"4","key":"2021120907215454400_B3","doi-asserted-by":"crossref","first-page":"312","DOI":"10.2350\/14-04-1462-CR.1","article-title":"Bartonella henselae endocarditis and glomerulonephritis with dominant C3 deposition in a 21-year-old male with a Melody transcatheter pulmonary valve: case report and review of the literature.","volume":"17","author":"Georgievskaya","year":"2014","journal-title":"Pediatr Dev Pathol"},{"issue":"10","key":"2021120907215454400_B4","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/eurheartj\/ehq520","article-title":"Percutaneous pulmonary valve implantation: two-centre experience with more than 100 patients.","volume":"32","author":"Eicken","year":"2011","journal-title":"Eur Heart J"},{"issue":"5","key":"2021120907215454400_B5","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1161\/CIRCULATIONAHA.109.921692","article-title":"Short- and medium-term outcomes after transcatheter pulmonary valve placement in the expanded multicenter US melody valve trial.","volume":"122","author":"McElhinney","year":"2010","journal-title":"Circulation"},{"issue":"15","key":"2021120907215454400_B6","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1161\/CIRCULATIONAHA.107.735779","article-title":"Percutaneous pulmonary valve implantation: impact of evolving technology and learning curve on clinical outcome.","volume":"117","author":"Lurz","year":"2008","journal-title":"Circulation"},{"issue":"2","key":"2021120907215454400_B7","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/ccd.24518","article-title":"Melody transcatheter pulmonary valve implantation. 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