{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:31:28Z","timestamp":1761863488444,"version":"3.40.5"},"reference-count":12,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12,1]]},"abstract":"<jats:p>The effects of an immunoadsorption procedure, specifically designed to remove immunoglobulin E (IgE), on food-induced anaphylaxis have never been evaluated. We evaluate the effects of IgE removal on the allergic thresholds to foods. A 6-year-old boy with anaphylaxis to multiple foods and steroid-resistant unstable allergic asthma displayed serum IgE levels of 2800 to 3500 kU\/L. To lower IgE serum concentrations, which could be overridden by a high dose of omalizumab, 1.5 plasma volumes were exchanged in 8 apheresis sessions. During the procedure, serum IgE levels fell to 309 kU\/L. After the procedure, the threshold of reactivity to baked milk increased from 0.125 to 5 g of milk protein (full tolerance) after the first session, and the threshold of reactivity to hazelnut increased from 0.037 to 0.142 g of protein after the first session, 0.377 g after the eighth, and 1.067 g (full tolerance) after the first administration of omalizumab. Immediately after the sixth IgE immunoadsorption, we started omalizumab therapy. In the next 40 days, the threshold of reactivity to hazelnut increased to 7.730 (full tolerance). Asthma control was obtained, treatment with montelukast was stopped, and fluticasone was tapered from 500 to 175 \u03bcg\/day. The boy became partially or fully tolerant to all the tested foods, and quality of life was improved. IgE immunoadsorption, used to establish the starting basis for omalizumab administration, is able to increase the tolerance threshold to foods.<\/jats:p>","DOI":"10.1542\/peds.2015-1757","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T02:14:19Z","timestamp":1448936059000},"page":"e1617-e1620","source":"Crossref","is-referenced-by-count":17,"title":["IgE Immunoadsorption Knocks Down the Risk of Food-Related Anaphylaxis"],"prefix":"10.1542","volume":"136","author":[{"given":"Lamia","family":"Dahdah","sequence":"first","affiliation":[{"name":"Departments of Pediatrics,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Ceccarelli","sequence":"additional","affiliation":[{"name":"Haematology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Amendola","sequence":"additional","affiliation":[{"name":"Psychology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Campagnano","sequence":"additional","affiliation":[{"name":"Diagnostics,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Cancrini","sequence":"additional","affiliation":[{"name":"Immunology, and The Bambino Ges\u00f9 Children\u2019s Research Hospital, Rome, Holy See"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Mazzina","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics,"},{"name":"Dietetic Sciences,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Fiocchi","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2015,12,1]]},"reference":[{"issue":"6","key":"2021120906142832700_B1","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.jaci.2014.08.018","article-title":"Fatal anaphylaxis in the United States, 1999\u20132010: temporal patterns and demographic associations.","volume":"134","author":"Jerschow","year":"2014","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"2021120906142832700_B2","first-page":"56","article-title":"Severe anaphylaxis to sheep\u2019s milk cheese in a child desensitized to cow\u2019s milk through specific oral tolerance induction.","volume":"45","author":"Tripodi","year":"2013","journal-title":"Eur Ann Allergy Clin Immunol"},{"issue":"6","key":"2021120906142832700_B3","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/ACI.0000000000000109","article-title":"Novel immunotherapy approaches to food allergy.","volume":"14","author":"Hayen","year":"2014","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"2021120906142832700_B4"},{"issue":"6","key":"2021120906142832700_B5","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1055\/s-0031-1287824","article-title":"Plasmapheresis prior to omalizumab administration in a 15-year-old boy with severe asthma and very high IgE levels: sustained effect over 2 years.","volume":"223","author":"Kerzel","year":"2011","journal-title":"Klin Padiatr"},{"key":"2021120906142832700_B6","first-page":"267","article-title":"Improvement of treatment-refractory atopic dermatitis by immunoadsorption: a pilot study","volume-title":"J Allergy Clin Immunol","author":"Kasperkiewicz","year":"2011"},{"issue":"6","key":"2021120906142832700_B7","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1513\/AnnalsATS.201405-199CME","article-title":"Severe asthma.","volume":"11","author":"Thomson","year":"2014","journal-title":"Ann Am Thorac Soc"},{"issue":"2","key":"2021120906142832700_B8","first-page":"135","article-title":"Compliance with pharmacologic prophylaxis and therapy in bronchial asthma.","volume":"73","author":"Fiocchi","year":"1994","journal-title":"Ann Allergy"},{"issue":"4","key":"2021120906142832700_B9","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.pcl.2009.05.016","article-title":"The Pediatric Quality of Life Inventory: measuring pediatric health-related quality of life from the perspective of children and their parents.","volume":"56","author":"Varni","year":"2009","journal-title":"Pediatr Clin North Am"},{"issue":"3","key":"2021120906142832700_B10","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1086\/302547","article-title":"Genetic linkage of hyper-IgE syndrome to chromosome 4.","volume":"65","author":"Grimbacher","year":"1999","journal-title":"Am J Hum Genet"},{"key":"2021120906142832700_B11","unstructured":"Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA). 2014. Available at: www.ginasthma.org\/"},{"issue":"12","key":"2021120906142832700_B12","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1001\/jamadermatol.2014.2082","article-title":"IgE-specific immunoadsorption for treatment of recalcitrant atopic dermatitis.","volume":"150","author":"Kasperkiewicz","year":"2014","journal-title":"JAMA Dermatol"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/136\/6\/e1617\/1061992\/peds_2015-1757.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/136\/6\/e1617\/1061992\/peds_2015-1757.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:34:20Z","timestamp":1639096460000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/136\/6\/e1617\/33868\/IgE-Immunoadsorption-Knocks-Down-the-Risk-of-Food"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,1]]},"references-count":12,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,12,1]]},"published-print":{"date-parts":[[2015,12,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2015-1757","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"type":"print","value":"0031-4005"},{"type":"electronic","value":"1098-4275"}],"subject":[],"published":{"date-parts":[[2015,12,1]]}}}