{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:01:19Z","timestamp":1780470079274,"version":"3.54.1"},"reference-count":29,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>To investigate the short- and long-term outcomes of children from pregnancies complicated with polyhydramnios, defined as amniotic fluid index (AFI) &amp;gt;24 cm, and with a normal detailed ultrasound examination.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>This retrospective cohort study examined 134 children aged 4 to 9 years with polyhydramnios and normal detailed ultrasound examination during pregnancy compared with 268 controls with normal AFI and normal detailed ultrasound examination matched for maternal age, year of delivery, gestational week at delivery, and presence or absence of diabetes. The primary outcome was the rate of malformations diagnosed postnatally. Additional outcomes were obstetrics outcomes, genetic syndromes, and neurodevelopment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Polyhydramnios was associated with increased risk for cesarean delivery (CD) and birth weight &amp;gt;90th percentile. This elevation in CD was attributed to increased rate of elective CD due to suspected macrosomia. Polyhydramnios was associated with increased risk for congenital malformations (n = 25 [19%] compared with 27 [10%], respectively; P = .016) without a statistically significant increase in the rate of major malformations (11 [8%] vs. 10 [4%]; P = .057). Genetic syndromes were more prevalent in the polyhydramnios group (5 [3.7%] vs. 2 [0.75%]; P = .043), as were neurologic disorders and developmental delay (9.7% vs. 3%; P = .004).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Despite a normal detailed ultrasound examination, polyhydramnios is associated with increased rate of fetal malformations, genetic syndromes, neurologic disorders, and developmental delay, which may be diagnosed only after birth.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2015-1948","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T02:39:41Z","timestamp":1452566381000},"source":"Crossref","is-referenced-by-count":29,"title":["Outcomes From Polyhydramnios With Normal Ultrasound"],"prefix":"10.1542","volume":"137","author":[{"given":"Enav","family":"Yefet","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etty","family":"Daniel-Spiegel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel; and"},{"name":"Ultrasound Unit, Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2016,2,1]]},"reference":[{"issue":"5","key":"2021120907144481900_B1","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/0002-9378(90)90009-V","article-title":"The amniotic fluid index in normal human pregnancy.","volume":"162","author":"Moore","year":"1990","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"2021120907144481900_B2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14767050802531870","article-title":"Idiopathic polyhydramnios and postnatal findings.","volume":"22","author":"Dorleijn","year":"2009","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"12","key":"2021120907144481900_B3","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1097\/01.ogx.0000290349.58707.e0","article-title":"A review of idiopathic hydramnios and pregnancy outcomes.","volume":"62","author":"Magann","year":"2007","journal-title":"Obstet Gynecol Surv"},{"issue":"5","key":"2021120907144481900_B4","first-page":"851","article-title":"Clinical relevance of sonographically estimated amniotic fluid volume: polyhydramnios.","volume":"32","author":"Sandlin","year":"2013","journal-title":"J Ultrasound Med"},{"issue":"1","key":"2021120907144481900_B5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2214\/ajr.148.1.155","article-title":"Severe polyhydramnios: incidence of anomalies.","volume":"148","author":"Barkin","year":"1987","journal-title":"AJR Am J Roentgenol"},{"issue":"1","key":"2021120907144481900_B6","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s00404-002-0353-0","article-title":"Incidence of fetal malformations in pregnancies complicated by oligo- and polyhydramnios.","volume":"268","author":"Pauer","year":"2003","journal-title":"Arch Gynecol Obstet"},{"issue":"4","key":"2021120907144481900_B7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1055\/s-2007-994599","article-title":"Significance of idiopathic midtrimester polyhydramnios.","volume":"11","author":"Glantz","year":"1994","journal-title":"Am J Perinatol"},{"issue":"2","key":"2021120907144481900_B8","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/00003081-199706000-00004","article-title":"Polyhydramnios.","volume":"40","author":"Moise","year":"1997","journal-title":"Clin Obstet Gynecol"},{"issue":"1","key":"2021120907144481900_B9","first-page":"21","article-title":"Perinatal outcomes of idiopathic polyhydramnios.","volume":"5","author":"Taskin","year":"2013","journal-title":"Interv Med Appl Sci"},{"issue":"5 pt 1","key":"2021120907144481900_B10","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0002-9378(99)70084-0","article-title":"Idiopathic polyhydramnios and perinatal outcome.","volume":"181","author":"Panting-Kemp","year":"1999","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"2021120907144481900_B11","first-page":"222","article-title":"Perinatal outcomes of polyhydramnios without associated congenital fetal anomalies after the gestational age of 20 weeks.","volume":"28","author":"Chen","year":"2005","journal-title":"Chang Gung Med J"},{"issue":"5","key":"2021120907144481900_B12","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1515\/jpme.1998.26.5.371","article-title":"Prevalence of polyhydramnios in the third trimester in a population screened by first and second trimester ultrasonography.","volume":"26","author":"Thompson","year":"1998","journal-title":"J Perinat Med"},{"issue":"6","key":"2021120907144481900_B13","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.7863\/jum.2013.32.6.1083","article-title":"AIUM practice guideline for the performance of obstetric ultrasound examinations.","volume":"32","author":"American Institute of Ultrasound in Medicine","year":"2013","journal-title":"J Ultrasound Med"},{"issue":"4","key":"2021120907144481900_B14","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/humupd\/dmt006","article-title":"Assisted reproductive technology and birth defects: a systematic review and meta-analysis.","volume":"19","author":"Hansen","year":"2013","journal-title":"Hum Reprod Update"},{"issue":"5","key":"2021120907144481900_B15","first-page":"311","article-title":"Birth weight standards in the live-born population in Israel.","volume":"7","author":"Dollberg","year":"2005","journal-title":"Isr Med Assoc J"},{"issue":"19","key":"2021120907144481900_B16","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1056\/NEJMoa1008095","article-title":"Reproductive technologies and the risk of birth defects.","volume":"366","author":"Davies","year":"2012","journal-title":"N Engl J Med"},{"issue":"12","key":"2021120907144481900_B17","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.3109\/14767058.2013.853736","article-title":"Polyhydramnios and adverse perinatal outcome: what is the actual cutoff?","volume":"27","author":"Harlev","year":"2014","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"5 pt 1","key":"2021120907144481900_B18","first-page":"773","article-title":"Hydramnios prediction of adverse perinatal outcome.","volume":"94","author":"Biggio","year":"1999","journal-title":"Obstet Gynecol"},{"issue":"2","key":"2021120907144481900_B19","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1447-0756.2009.01145.x","article-title":"Peripartum outcomes of high-risk pregnancies complicated by oligo- and polyhydramnios: a prospective longitudinal study.","volume":"36","author":"Magann","year":"2010","journal-title":"J Obstet Gynaecol Res"},{"issue":"1","key":"2021120907144481900_B20","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000292513","article-title":"Persistence of polyhydramnios during pregnancy: its significance and correlation with maternal and fetal complications.","volume":"37","author":"Golan","year":"1994","journal-title":"Gynecol Obstet Invest"},{"issue":"3","key":"2021120907144481900_B21","first-page":"186","article-title":"Intrapartum hydramnios at term and perinatal outcome.","volume":"13","author":"Chauhan","year":"1993","journal-title":"J Perinatol"},{"issue":"5","key":"2021120907144481900_B22","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1080\/00016340802012254","article-title":"Development and validation of a nomogram to predict the risk of cesarean delivery in macrosomia.","volume":"87","author":"Mazouni","year":"2008","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"4","key":"2021120907144481900_B23","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1097\/01.AOG.0000139515.97799.f6","article-title":"Gestational weight gain, macrosomia, and risk of cesarean birth in nondiabetic nulliparas.","volume":"104","author":"Stotland","year":"2004","journal-title":"Obstet Gynecol"},{"issue":"1","key":"2021120907144481900_B24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1055\/s-0034-1376182","article-title":"Counseling for fetal macrosomia: an estimated fetal weight of 4,000 g is excessively low.","volume":"32","author":"Peleg","year":"2014","journal-title":"Am J Perinatol"},{"issue":"1","key":"2021120907144481900_B25","first-page":"17","article-title":"Ultrasonographic prediction of fetal macrosomia. Association with cesarean delivery.","volume":"45","author":"Parry","year":"2000","journal-title":"J Reprod Med"},{"issue":"8","key":"2021120907144481900_B26","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1093\/humrep\/17.8.2089","article-title":"Congenital malformations in 4224 children conceived after IVF.","volume":"17","author":"Anthony","year":"2002","journal-title":"Hum Reprod"},{"issue":"6","key":"2021120907144481900_B27","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/j.fertnstert.2009.12.031","article-title":"Perinatal risk in singleton pregnancies after in vitro fertilization.","volume":"94","author":"Fujii","year":"2010","journal-title":"Fertil Steril"},{"issue":"1","key":"2021120907144481900_B28","first-page":"134","article-title":"Hydramnios: anomaly prevalence and sonographic detection.","volume":"100","author":"Dashe","year":"2002","journal-title":"Obstet Gynecol"},{"issue":"4","key":"2021120907144481900_B29","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s004670050461","article-title":"Bartter and related syndromes: the puzzle is almost solved.","volume":"12","author":"Rodr\u00edguez-Soriano","year":"1998","journal-title":"Pediatr Nephrol"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2015-1948\/1095453\/peds_20151948.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2015-1948\/1095453\/peds_20151948.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T01:45:07Z","timestamp":1639100707000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/137\/2\/e20151948\/52701\/Outcomes-From-Polyhydramnios-With-Normal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,1]]},"references-count":29,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,1]]},"published-print":{"date-parts":[[2016,2,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2015-1948","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,1]]},"article-number":"e20151948"}}