{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:15:35Z","timestamp":1761920135570,"version":"3.41.2"},"reference-count":11,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"abstract":"<jats:p>Myelin oligodendrocyte glycoprotein (MOG) is a candidate target antigen in demyelinating central nervous system diseases, including acute disseminated encephalomyelitis (ADEM), neuromyelitis optica, and multiple sclerosis. It may give prognostic information regarding monophasic or recurrent course of the disease. MOG antibodies have been shown to be positive in high titers during the first episode of ADEM with rapidly decreasing to undetectable limits after recovery. However, persistent MOG antibodies are considered as a predicting factor for multiple sclerosis, optic neuritis relapses, and incomplete recovery of ADEM. Here we report a unique case with persistent MOG antibodies presented with multiphasic ADEM-like attacks. A 6-year-old girl was consulted with encephalopathy, gait disturbance, and oculomotor nerve palsy. Periventricular white matter lesions were seen on cranial magnetic resonance imaging studies. ADEM was diagnosed and treated with steroid. During follow-up, she experienced repeated episodes after steroid therapy termination. We were able to search MOG antibody at the ninth attack. The positivity of this antibody remained. It was thought to be associated with steroid-dependent course, and azathioprine and intravenous human immunoglobulin treatment were added. Patients with persistent MOG antibodies may benefit from addition of immunosuppressant agents, which may decrease the number of attacks.<\/jats:p>","DOI":"10.1542\/peds.2015-1958","type":"journal-article","created":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T12:22:20Z","timestamp":1461673340000},"source":"Crossref","is-referenced-by-count":7,"title":["Myelin Oligodendrocyte Glycoprotein Antibody Persistency in a Steroid-Dependent ADEM Case"],"prefix":"10.1542","volume":"137","author":[{"given":"\u0130pek","family":"Polat","sequence":"first","affiliation":[{"name":"Departments of Pediatric Neurology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulu\u00e7","family":"Yi\u015f","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Neurology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pakize","family":"Karao\u011flu","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Neurology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muge","family":"Ayano\u011flu","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Neurology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00fclay","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Pediatric Radiology, Dokuz Eyl\u00fcl University School of Medicine, \u0130zmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Handan","family":"G\u00fclery\u00fcz","sequence":"additional","affiliation":[{"name":"Pediatric Radiology, Dokuz Eyl\u00fcl University School of Medicine, \u0130zmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semra H\u0131z","family":"Kurul","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Neurology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2016,5,1]]},"reference":[{"issue":"3","key":"2021120904334626400_B1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/WCO.0b013e3283533a64","article-title":"Identifying autoantigens in demyelinating diseases: valuable clues to diagnosis and treatment?","volume":"25","author":"Derfuss","year":"2012","journal-title":"Curr Opin Neurol"},{"issue":"1-2","key":"2021120904334626400_B2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0165-5728(02)00434-4","article-title":"Anti-myelin oligodendrocyte glycoprotein B-cell responses in multiple sclerosis.","volume":"135","author":"Kennel De March","year":"2003","journal-title":"J Neuroimmunol"},{"issue":"3","key":"2021120904334626400_B3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.clim.2010.11.013","article-title":"Temporal dynamics of anti-MOG antibodies in CNS demyelinating diseases.","volume":"138","author":"Di Pauli","year":"2011","journal-title":"Clin Immunol"},{"issue":"10","key":"2021120904334626400_B4","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1177\/1352458513484547","article-title":"International Pediatric Multiple Sclerosis Study Group. International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune mediated central nervous system demyelinating disorders: revisions to the 2007 definitions.","volume":"19","author":"Krupp","year":"2013","journal-title":"Mult Scler"},{"key":"2021120904334626400_B5","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.4103\/0972-2327.83095","article-title":"Acute disseminated encephalomyelitis: treatment guidelines.","volume":"14","author":"Alexander","year":"2011","journal-title":"Ann Indian Acad Neurol"},{"issue":"6","key":"2021120904334626400_B6","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/ana.21916","article-title":"Antibodies to native myelin oligodendrocyte glycoprotein in children with inflammatory demyelinating central nervous system disease.","volume":"66","author":"Brilot","year":"2009","journal-title":"Ann Neurol"},{"issue":"3","key":"2021120904334626400_B7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/1756285611433772","article-title":"Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more.","volume":"5","author":"Mayer","year":"2012","journal-title":"Ther Adv Neurol Disorder"},{"issue":"8","key":"2021120904334626400_B8","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1177\/1352458512470310","article-title":"Persisting myelin oligodendrocyte glycoprotein antibodies in aquaporin-4 antibody negative pediatric neuromyelitis optica.","volume":"19","author":"Rost\u00e1sy","year":"2013","journal-title":"Mult Scler"},{"issue":"3","key":"2021120904334626400_B9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1136\/jnnp-2014-308346","article-title":"Clinical and neuroradiological differences of pediatric acute disseminating encephalomyelitis with and without antibodies to myelin oligodendrocyte glycoproteins.","volume":"86","author":"Baumann","year":"2014","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"6","key":"2021120904334626400_B10","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1212\/WNL.0000000000000101","article-title":"Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders.","volume":"82","author":"Sato","year":"2014","journal-title":"Neurology"},{"key":"2021120904334626400_B11","unstructured":"EUROIMUNN AG\n          . Autoantibodies against neuronal antigens. Available at: http:\/\/www.labor-stoecker.de\/fileadmin\/template\/images\/pdf\/qr\/info_autoimmune_encephalitis_en.pdf"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2015-1958\/1060588\/peds_20151958.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2015-1958\/1060588\/peds_20151958.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T21:28:23Z","timestamp":1639085303000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/137\/5\/e20151958\/52004\/Myelin-Oligodendrocyte-Glycoprotein-Antibody"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,1]]},"references-count":11,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,1]]},"published-print":{"date-parts":[[2016,5,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2015-1958","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"type":"print","value":"0031-4005"},{"type":"electronic","value":"1098-4275"}],"subject":[],"published":{"date-parts":[[2016,5,1]]},"article-number":"e20151958"}}