{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:35:13Z","timestamp":1791315313346,"version":"4.3.1"},"reference-count":36,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>To investigate the relationship between placenta-mediated pregnancy complications and bronchopulmonary dysplasia (BPD) in very preterm infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>National prospective population-based cohort study including 2697 singletons born before 32 weeks\u2019 gestation. The main outcome measure was moderate to severe BPD. Three groups of placenta-mediated pregnancy complications were compared with no placenta-mediated complications: maternal disorders only (gestational hypertension or preeclampsia), fetal disorders only (antenatal growth restriction), and both maternal and fetal disorders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Moderate to severe BPD rates were 8% in infants from pregnancies with maternal disorders, 15% from both maternal and fetal disorders, 23% from fetal disorders only, and 9% in the control group (P &amp;lt; .001). When we adjusted for gestational age, the risk of moderate to severe BPD was greater in the groups with fetal disorders only (odds ratio [OR] = 6.6; 95% confidence interval [CI], 4.1\u201310.7), with maternal and fetal disorders (OR = 3.7; 95% CI, 2.5\u20135.5), and with maternal disorders only (OR = 1.7; 95% CI, 1.0\u20132.7) than in the control group. When we also controlled for birth weight, the relationship remained in groups with fetal disorders only (OR = 4.2; 95% CI, 2.1\u20138.6) and with maternal and fetal disorders (OR = 2.1; 95% CI, 1.1\u20133.9).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Placenta-mediated pregnancy complications with fetal consequences are associated with moderate to severe BPD in very preterm infants independently of gestational age and birth weight, but isolated maternal hypertensive disorders are not. Fetal growth restriction, more than birth weight, could predispose to impaired lung development.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2015-2163","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T02:39:12Z","timestamp":1455849552000},"source":"Crossref","is-referenced-by-count":66,"title":["Placental Complications and Bronchopulmonary Dysplasia: EPIPAGE-2 Cohort Study"],"prefix":"10.1542","volume":"137","author":[{"given":"H\u00e9lo\u00efse","family":"Torchin","sequence":"first","affiliation":[{"name":"INSERM U1153, Epidemiology and Statistics Sorbonne Paris Cit\u00e9 Research Center, Obstetrical, Perinatal and Pediatric Epidemiology Team, Paris, France;"},{"name":"DHU Risk in Pregnancy, Cochin Hotel-Dieu Hospital, Assistance-Publique H\u00f4pitaux de Paris, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Ancel","sequence":"additional","affiliation":[{"name":"INSERM U1153, Epidemiology and Statistics Sorbonne Paris Cit\u00e9 Research Center, Obstetrical, Perinatal and Pediatric Epidemiology Team, Paris, France;"},{"name":"DHU Risk in Pregnancy, Cochin Hotel-Dieu Hospital, Assistance-Publique H\u00f4pitaux de Paris, Paris, France;"},{"name":"Paris Descartes University, Paris, France;"},{"name":"Unit\u00e9 de Recherche Clinique - Centre d' Investigation Clinique;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Goffinet","sequence":"additional","affiliation":[{"name":"INSERM U1153, Epidemiology and Statistics Sorbonne Paris Cit\u00e9 Research Center, Obstetrical, Perinatal and Pediatric Epidemiology Team, Paris, France;"},{"name":"DHU Risk in Pregnancy, Cochin Hotel-Dieu Hospital, Assistance-Publique H\u00f4pitaux de Paris, Paris, France;"},{"name":"Paris Descartes University, Paris, France;"},{"name":"Maternit\u00e9 Port-Royal, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Hasco\u00ebt","sequence":"additional","affiliation":[{"name":"Maternite Regionale Universitaire, Neonatology, Nancy, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Truffert","sequence":"additional","affiliation":[{"name":"Jeanne de Flandre Hospital, Department of Neonatology CHRU de Lille, Lille Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diep","family":"Tran","sequence":"additional","affiliation":[{"name":"INSERM U1153, Epidemiology and Statistics Sorbonne Paris Cit\u00e9 Research Center, Obstetrical, Perinatal and Pediatric Epidemiology Team, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Lebeaux","sequence":"additional","affiliation":[{"name":"INSERM U1153, Epidemiology and Statistics Sorbonne Paris Cit\u00e9 Research Center, Obstetrical, Perinatal and Pediatric Epidemiology Team, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Henri","family":"Jarreau","sequence":"additional","affiliation":[{"name":"DHU Risk in Pregnancy, Cochin Hotel-Dieu Hospital, Assistance-Publique H\u00f4pitaux de Paris, Paris, France;"},{"name":"Paris Descartes University, Paris, France;"},{"name":"Service de M\u00e9decine et R\u00e9animation N\u00e9onatales de Port-Royal, Assistance Publique, H\u00f4pitaux de Paris, H\u00f4pital Cochin, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2016,3,1]]},"reference":[{"issue":"7","key":"2021120919125481900_B1","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0046-8177(98)90280-5","article-title":"Pathology of arrested acinar development in postsurfactant bronchopulmonary dysplasia.","volume":"29","author":"Husain","year":"1998","journal-title":"Hum Pathol"},{"issue":"10 pt 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