{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:04:26Z","timestamp":1793736266585,"version":"4.6.1"},"reference-count":15,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:p>The study of vascular anomalies is a rapidly progressing field in medicine. The development of new knowledge in the pathology and management of these disease processes are exemplified in the treatment of hemangiomas with propranolol and generalized lymphatic malformations with sirolimus. Central conducting lymphatic anomalies have traditionally been refractory to medical and surgical interventions. We report a case of a central conducting lymphatic anomaly that was responsive to sirolimus. A 14-year-old boy presented with chylothorax and chyluria with a lymphangiogram demonstrating abnormal lymphatic flow and reflux along the entire course of the central channels. Traditionally, medical management has been limited to somatostatin and low-fat diet with poor response and surgical interventions that are palliative. Sirolimus allows a new medical option that could improve management of this unresponsive population.<\/jats:p>","DOI":"10.1542\/peds.2015-2694","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T20:48:14Z","timestamp":1451940494000},"source":"Crossref","is-referenced-by-count":31,"title":["A Case of a Central Conducting Lymphatic Anomaly Responsive to Sirolimus"],"prefix":"10.1542","volume":"137","author":[{"given":"Andrew","family":"McCormick","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Vascular Anomalies Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Tier","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, 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