{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:15:04Z","timestamp":1787022904021,"version":"build-2736575974"},"reference-count":60,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>We aimed to describe the clinical features and outcome of human parechovirus (HPeV) encephalitis cases identified by the Australian Childhood Encephalitis (ACE) study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Infants with suspected encephalitis were prospectively identified in 5 hospitals through the (ACE) study. Cases of confirmed HPeV infection had comprehensive demographic, clinical, laboratory, imaging, and outcome at discharge data reviewed by an expert panel and were categorized by using predetermined case definitions. Twelve months after discharge, neurodevelopment was assessed by using the Ages and Stages Questionnaire (ASQ).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>We identified thirteen cases of suspected encephalitis with HPeV infection between May 2013 and December 2014. Nine infants had confirmed encephalitis; median age was 13 days, including a twin pair. All had HPeV detected in cerebrospinal fluid with absent pleocytosis. Most were girls (7), admitted to ICU (8), and had seizures (8). Many were born preterm (5). Seven patients had white matter diffusion restriction on MRI; 3 with normal cranial ultrasounds. At discharge, 3 of 9 were assessed to have sequelae; however, at 12 months\u2019 follow-up, by using the ASQ, 5 of 8 infants showed neurodevelopmental sequelae: 3 severe (2 cerebral palsy, 1 central visual impairment). A further 2 showed concern in gross motor development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Children with HPeV encephalitis were predominantly young, female infants with seizures and diffusion restriction on MRI. Cranial ultrasound is inadequately sensitive. HPeV encephalitis is associated with neurodevelopmental sequelae despite reassuring short-term outcomes. Given the absent cerebrospinal fluid pleocytosis and need for specific testing, HPeV could be missed as a cause of neonatal encephalopathy and subsequent cerebral palsy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2015-2848","type":"journal-article","created":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T21:23:59Z","timestamp":1453325039000},"source":"Crossref","is-referenced-by-count":131,"title":["Parechovirus Encephalitis and Neurodevelopmental Outcomes"],"prefix":"10.1542","volume":"137","author":[{"given":"Philip N.","family":"Britton","sequence":"first","affiliation":[{"name":"Sydney Medical School, Sydney, Australia;"},{"name":"Marie Bashir Institute of Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia;"},{"name":"Department of Infectious Diseases and Microbiology, The Children\u2019s Hospital at Westmead, Sydney, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell C.","family":"Dale","sequence":"additional","affiliation":[{"name":"Sydney Medical School, Sydney, Australia;"},{"name":"Department of Neurology, The Children's Hospital at Westmead, Sydney, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Nissen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Royal Children\u2019s Hospital, Brisbane, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Crawford","sequence":"additional","affiliation":[{"name":"SAEFVIC, Murdoch Children\u2019s Research Institute, Melbourne, Australia;"},{"name":"Department of General Medicine, Royal Children\u2019s Hospital, Melbourne, Australia;"},{"name":"Department of Paediatrics, The University of Melbourne, Melbourne, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Elliott","sequence":"additional","affiliation":[{"name":"Sydney Medical School, Sydney, Australia;"},{"name":"Department of Infectious Diseases and Microbiology, The Children\u2019s Hospital at Westmead, Sydney, Australia;"},{"name":"Australian Paediatric Surveillance Unit, Sydney, Australia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Macartney","sequence":"additional","affiliation":[{"name":"Sydney Medical School, Sydney, Australia;"},{"name":"Department of Infectious Diseases and Microbiology, The Children\u2019s Hospital at Westmead, Sydney, Australia;"},{"name":"National Centre for Immunization Research and Surveillance, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulam","family":"Khandaker","sequence":"additional","affiliation":[{"name":"Sydney Medical School, Sydney, Australia;"},{"name":"National Centre for Immunization Research and Surveillance, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Booy","sequence":"additional","affiliation":[{"name":"Sydney Medical School, Sydney, Australia;"},{"name":"Marie Bashir Institute of Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia;"},{"name":"Department of Infectious Diseases and Microbiology, The Children\u2019s Hospital at Westmead, Sydney, Australia;"},{"name":"National Centre for Immunization Research and Surveillance, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl A.","family":"Jones","sequence":"additional","affiliation":[{"name":"Sydney Medical School, Sydney, Australia;"},{"name":"Marie Bashir Institute of Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia;"},{"name":"Department of Infectious Diseases and Microbiology, The Children\u2019s Hospital at Westmead, Sydney, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the PAEDS-ACE Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2016,2,1]]},"reference":[{"issue":"2","key":"2021120907154215700_B1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1386-6532(02)00009-4","article-title":"Encephalomyelitis due to human parechovirus type 1.","volume":"25","author":"Legay","year":"2002","journal-title":"J Clin Virol"},{"issue":"2","key":"2021120907154215700_B2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1086\/498905","article-title":"Human parechovirus infections in Dutch children and the association between serotype and disease severity.","volume":"42","author":"Benschop","year":"2006","journal-title":"Clin Infect Dis"},{"issue":"3","key":"2021120907154215700_B3","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/ana.21445","article-title":"Human parechovirus causes encephalitis with white matter injury in neonates.","volume":"64","author":"Verboon-Maciolek","year":"2008","journal-title":"Ann Neurol"},{"issue":"12","key":"2021120907154215700_B4","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1097\/INF.0000000000000456","article-title":"Severe parechovirus infection in Norwegian infants.","volume":"33","author":"Skram","year":"2014","journal-title":"Pediatr Infect Dis J"},{"issue":"11","key":"2021120907154215700_B5","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1097\/INF.0000000000000401","article-title":"Human parechovirus type 3 and 4 associated with severe infections in young children.","volume":"33","author":"Kolehmainen","year":"2014","journal-title":"Pediatr Infect Dis J"},{"issue":"4","key":"2021120907154215700_B6","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1097\/INF.0000000000000112","article-title":"Human parechovirus central nervous system infections in southern California children.","volume":"33","author":"Felsenstein","year":"2014","journal-title":"Pediatr Infect Dis J"},{"key":"2021120907154215700_B7","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1016\/S0378-3782(14)70023-4","article-title":"Human enterovirus and parechovirus infections in newborns with sepsis-like illness and neurological disorders.","volume":"90","author":"Piralla","year":"2014","journal-title":"Early Hum Dev"},{"issue":"6","key":"2021120907154215700_B8","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/INF.0b013e318194596a","article-title":"Human parechovirus-3 infection: emerging pathogen in neonatal sepsis.","volume":"28","author":"Levorson","year":"2009","journal-title":"Pediatr Infect Dis J"},{"issue":"12","key":"2021120907154215700_B9","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1086\/599094","article-title":"Specific association of human parechovirus type 3 with sepsis and fever in young infants, as identified by direct typing of cerebrospinal fluid samples.","volume":"199","author":"Harvala","year":"2009","journal-title":"J Infect Dis"},{"issue":"10","key":"2021120907154215700_B10","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1002\/jmv.21878","article-title":"Human parechoviruses in infants with systemic infection.","volume":"82","author":"Pi\u00f1eiro","year":"2010","journal-title":"J Med Virol"},{"issue":"3","key":"2021120907154215700_B11","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/INF.0b013e3181fbefc8","article-title":"Human parechovirus 3 causing sepsis-like illness in children from midwestern United States.","volume":"30","author":"Selvarangan","year":"2011","journal-title":"Pediatr Infect Dis J"},{"issue":"5","key":"2021120907154215700_B12","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/jmv.22023","article-title":"Comparison of human parechovirus and enterovirus detection frequencies in cerebrospinal fluid samples collected over a 5-year period in Edinburgh: HPeV type 3 identified as the most common picornavirus type.","volume":"83","author":"Harvala","year":"2011","journal-title":"J Med Virol"},{"issue":"3","key":"2021120907154215700_B13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jcv.2011.07.008","article-title":"Detection of human parechovirus (HPeV)-3 in spinal fluid specimens from pediatric patients in the Chicago area.","volume":"52","author":"Walters","year":"2011","journal-title":"J Clin Virol"},{"issue":"4","key":"2021120907154215700_B14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jcv.2012.04.016","article-title":"Human parechovirus infections, Lyon, France, 2008-10: evidence for severe cases.","volume":"54","author":"Schuffenecker","year":"2012","journal-title":"J Clin Virol"},{"issue":"1","key":"2021120907154215700_B15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3201\/eid2001.130569","article-title":"Human parechovirus infection, Denmark.","volume":"20","author":"Fischer","year":"2014","journal-title":"Emerg Infect Dis"},{"issue":"3","key":"2021120907154215700_B16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/INF.0b013e318276b328","article-title":"Characteristics of young infants in whom human parechovirus, enterovirus or neither were detected in cerebrospinal fluid during sepsis evaluations.","volume":"32","author":"Sharp","year":"2013","journal-title":"Pediatr Infect Dis J"},{"issue":"1","key":"2021120907154215700_B17","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jcv.2013.05.023","article-title":"Human parechovirus-3 infection in children, South Korea.","volume":"58","author":"Han","year":"2013","journal-title":"J Clin Virol"},{"issue":"1","key":"2021120907154215700_B18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jcv.2013.06.001","article-title":"Human parechovirus type 3 central nervous system infections in Israeli infants.","volume":"58","author":"Ghanem-Zoubi","year":"2013","journal-title":"J Clin Virol"},{"issue":"5","key":"2021120907154215700_B19","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1136\/archdischild-2011-300517","article-title":"Paediatric sepsis-like illness and human parechovirus.","volume":"97","author":"Vanagt","year":"2012","journal-title":"Arch Dis Child"},{"issue":"3","key":"2021120907154215700_B20","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1086\/589752","article-title":"Human parechoviruses as an important viral cause of sepsislike illness and meningitis in young children.","volume":"47","author":"Wolthers","year":"2008","journal-title":"Clin Infect Dis"},{"issue":"6","key":"2021120907154215700_B21","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3201\/eid1206.051675","article-title":"Human parechovirus types 1, 2 and 3 infections in Canada.","volume":"12","author":"Abed","year":"2006","journal-title":"Emerg Infect Dis"},{"issue":"4","key":"2021120907154215700_B22","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/jmv.23197","article-title":"Human parechovirus infections in patients admitted to hospital in Northern Italy, 2008-2010.","volume":"84","author":"Piralla","year":"2012","journal-title":"J Med Virol"},{"issue":"6","key":"2021120907154215700_B23","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s13365-013-0221-7","article-title":"Genotyping of human parechoviruses in Iranian young children with aseptic meningitis and sepsis-like illness.","volume":"19","author":"Rahimi","year":"2013","journal-title":"J Neurovirol"},{"issue":"2","key":"2021120907154215700_B24","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/jmv.23449","article-title":"Prevalence of human parechoviruses in central nervous system infections in children: a retrospective study in Shanghai, China.","volume":"85","author":"Zhong","year":"2013","journal-title":"J Med Virol"},{"issue":"1","key":"2021120907154215700_B25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jinf.2014.02.017","article-title":"Distinct systemic and central nervous system disease patterns in enterovirus and parechovirus infected children.","volume":"69","author":"Harvala","year":"2014","journal-title":"J Infect"},{"issue":"2","key":"2021120907154215700_B26","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.pediatrneurol.2014.09.019","article-title":"Human parechovirus-3 encephalitis in two neonates: acute and follow-up magnetic resonance imaging and evaluation of central nervous system markers of inflammation.","volume":"52","author":"Brownell","year":"2015","journal-title":"Pediatr Neurol"},{"issue":"6","key":"2021120907154215700_B27","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ejpn.2009.12.007","article-title":"Extensive white matter abnormalities associated with neonatal parechovirus (HPeV) infection.","volume":"14","author":"Gupta","year":"2010","journal-title":"Eur J Paediatr Neurol"},{"issue":"12","key":"2021120907154215700_B28","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1086\/509330","article-title":"Beyond viruses: clinical profiles and etiologies associated with encephalitis.","volume":"43","author":"Glaser","year":"2006","journal-title":"Clin Infect Dis"},{"issue":"12","key":"2021120907154215700_B29","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S1473-3099(10)70222-X","article-title":"Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study","volume":"10","author":"Granerod","year":"2010","journal-title":"Lancet Infect Dis"},{"issue":"12","key":"2021120907154215700_B30","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1086\/648419","article-title":"Infectious encephalitis in France in 2007: a national prospective study.","volume":"49","author":"Mailles","year":"2009","journal-title":"Clin Infect Dis"},{"issue":"31","key":"2021120907154215700_B31","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1016\/j.vaccine.2007.04.060","article-title":"Encephalitis, myelitis, and acute disseminated encephalomyelitis (ADEM): case definitions and guidelines for collection, analysis, and presentation of immunization safety data.","volume":"25","author":"Sejvar","year":"2007","journal-title":"Vaccine"},{"issue":"8","key":"2021120907154215700_B32","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/cid\/cit458","article-title":"Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium.","volume":"57","author":"Venkatesan","year":"2013","journal-title":"Clin Infect Dis"},{"issue":"7","key":"2021120907154215700_B33","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/jpc.12282","article-title":"Paediatric active enhanced disease surveillance: a new surveillance system for Australia.","volume":"49","author":"Zurynski","year":"2013","journal-title":"J Paediatr Child Health"},{"issue":"2","key":"2021120907154215700_B34","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/cid\/ciu784","article-title":"Sepsis-like disease in infants due to human parechovirus type 3 during an outbreak in Australia.","volume":"60","author":"Khatami","year":"2015","journal-title":"Clin Infect Dis"},{"issue":"9","key":"2021120907154215700_B35","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1002\/jmv.23885","article-title":"Detection and genotyping of enteroviruses in cerebrospinal fluid in patients in Victoria, Australia, 2007-2013.","volume":"86","author":"Papadakis","year":"2014","journal-title":"J Med Virol"},{"issue":"2","key":"2021120907154215700_B36","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jcv.2007.10.004","article-title":"Rapid detection of human parechoviruses in clinical samples by real-time PCR.","volume":"41","author":"Benschop","year":"2008","journal-title":"J Clin Virol"},{"issue":"7905","key":"2021120907154215700_B37","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S0140-6736(75)92830-5","article-title":"Assessment of outcome after severe brain damage.","volume":"1","author":"Jennett","year":"1975","journal-title":"Lancet"},{"issue":"7","key":"2021120907154215700_B38","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.3201\/eid2107.141149","article-title":"Parechovirus genotype 3 outbreak among infants, New South Wales, Australia, 2013\u20132014.","volume":"21","author":"Cumming","year":"2015","journal-title":"Emerg Infect Dis"},{"issue":"9","key":"2021120907154215700_B39","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/jpc.12704","article-title":"Identification of human parechovirus-3 in young infants within rural Victoria.","volume":"50","author":"Cooper","year":"2014","journal-title":"J Paediatr Child Health"},{"issue":"3","key":"2021120907154215700_B40","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/INF.0b013e31815c1b07","article-title":"Severe neonatal parechovirus infection and similarity with enterovirus infection.","volume":"27","author":"Verboon-Maciolek","year":"2008","journal-title":"Pediatr Infect Dis J"},{"issue":"3","key":"2021120907154215700_B41","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1212\/WNL.0000000000000040","article-title":"Teaching neuroimages: neonatal parechovirus encephalitis: typical MRI findings.","volume":"82","author":"Belcastro","year":"2014","journal-title":"Neurology"},{"issue":"10","key":"2021120907154215700_B42","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/jpc.12656","article-title":"Enterovirus infections are associated with white matter damage in neonates.","volume":"50","author":"Wu","year":"2014","journal-title":"J Paediatr Child Health"},{"issue":"8","key":"2021120907154215700_B43","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1212\/01.wnl.0000208429.69676.23","article-title":"White matter damage in neonatal enterovirus meningoencephalitis.","volume":"66","author":"Verboon-Maciolek","year":"2006","journal-title":"Neurology"},{"issue":"2","key":"2021120907154215700_B44","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/mrdd.20107","article-title":"Perinatal white matter injury: the changing spectrum of pathology and emerging insights into pathogenetic mechanisms.","volume":"12","author":"Back","year":"2006","journal-title":"Ment Retard Dev Disabil Res Rev"},{"issue":"7","key":"2021120907154215700_B45","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1056\/NEJMoa053792","article-title":"Neonatal MRI to predict neurodevelopmental outcomes in preterm infants.","volume":"355","author":"Woodward","year":"2006","journal-title":"N Engl J Med"},{"issue":"2","key":"2021120907154215700_B46","doi-asserted-by":"crossref","first-page":"F153","DOI":"10.1136\/adc.2006.108837","article-title":"Pathogenesis of cerebral white matter injury of prematurity.","volume":"93","author":"Khwaja","year":"2008","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2021120907154215700_B47","author":"Kadhim","year":"2002"},{"issue":"10","key":"2021120907154215700_B48","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1212\/WNL.56.10.1278","article-title":"Inflammatory cytokines in the pathogenesis of periventricular leukomalacia.","volume":"56","author":"Kadhim","year":"2001","journal-title":"Neurology"},{"issue":"3","key":"2021120907154215700_B49","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/ana.21466","article-title":"Neonatal encephalitis and white matter injury: more than just inflammation?","volume":"64","author":"Volpe","year":"2008","journal-title":"Ann Neurol"},{"issue":"pt 11","key":"2021120907154215700_B50","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1099\/vir.0.043323-0","article-title":"Specific cell tropism and neutralization of human parechovirus types 1 and 3: implications for pathogenesis and therapy development.","volume":"93","author":"Westerhuis","year":"2012","journal-title":"J Gen Virol"},{"issue":"3","key":"2021120907154215700_B51","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1086\/649863","article-title":"Infant deaths associated with human parechovirus infection in Wisconsin.","volume":"50","author":"Sedmak","year":"2010","journal-title":"Clin Infect Dis"},{"key":"2021120907154215700_B52","author":"van Zwol","year":"2009"},{"issue":"4","key":"2021120907154215700_B53","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2014-2702","article-title":"Infectious and autoantibody-associated encephalitis: clinical features and long-term outcome.","volume":"135","author":"Pillai","year":"2015","journal-title":"Pediatrics"},{"issue":"1","key":"2021120907154215700_B54","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00234-014-1449-5","article-title":"Childhood encephalitis: relationship between diffusion abnormalities and clinical outcome.","volume":"57","author":"Wong","year":"2015","journal-title":"Neuroradiology"},{"issue":"1","key":"2021120907154215700_B55","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ajhg.2008.12.009","article-title":"Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2.","volume":"84","author":"Neilson","year":"2009","journal-title":"Am J Hum Genet"},{"issue":"5797","key":"2021120907154215700_B56","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1126\/science.1128346","article-title":"Herpes simplex virus encephalitis in human UNC-93B deficiency.","volume":"314","author":"Casrouge","year":"2006","journal-title":"Science"},{"issue":"12","key":"2021120907154215700_B57","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1586\/eri.10.130","article-title":"The need for treatment against human parechoviruses: how, why and when?","volume":"8","author":"Wildenbeest","year":"2010","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"11","key":"2021120907154215700_B58","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S1474-4422(10)70209-X","article-title":"Clinical features, diagnosis, and management of enterovirus 71.","volume":"9","author":"Ooi","year":"2010","journal-title":"Lancet Neurol"},{"issue":"6","key":"2021120907154215700_B59","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1097\/MOP.0b013e3283402b71","article-title":"Biomarkers of inflammatory and auto-immune central nervous system disorders.","volume":"22","author":"Dale","year":"2010","journal-title":"Curr Opin Pediatr"},{"key":"2021120907154215700_B60","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jcv.2015.07.300","article-title":"Asymptomatic children might transmit human parechovirus type 3 to neonates and young infants.","volume":"70","author":"Aizawa","year":"2015","journal-title":"J Clin Virol"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2015-2848\/1094735\/peds_20152848.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2015-2848\/1094735\/peds_20152848.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T20:47:09Z","timestamp":1639082829000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/137\/2\/e20152848\/52723\/Parechovirus-Encephalitis-and-Neurodevelopmental"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,1]]},"references-count":60,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,1]]},"published-print":{"date-parts":[[2016,2,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2015-2848","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,1]]},"article-number":"e20152848"}}