{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:28:33Z","timestamp":1773685713538,"version":"3.50.1"},"reference-count":19,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:p>We experienced the case of a 3-year-old male with a very rare combination of autoimmunity, including immune thrombocytopenia, recurrent Henoch-Sch\u00f6nlein purpura and intestinal Beh\u00e7et disease. Exome sequencing of the patient\u2019s peripheral blood mononuclear cells identified a KRAS G13C mutation. Interestingly, the KRAS G13C mutation was observed in T and B lymphocytes, as well as natural killer cells, but not granulocytes. Our case was completely phenotypically different from RASopathies and did not meet the criteria for Ras-associated lymphoproliferative disease or juvenile myelomonocytic leukemia. This is the first reported case in which the KRAS mutation existed only in the lymphoid lineage. Based on the findings of our case and the current literature, it is clear that the RAS mutation in lymphoid cells is tightly linked with various autoimmune symptoms. The presence of the RAS mutation in lymphocytes should be reconsidered as a pathogenesis in cases of autoimmunity.<\/jats:p>","DOI":"10.1542\/peds.2015-2891","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T03:00:50Z","timestamp":1456282850000},"source":"Crossref","is-referenced-by-count":14,"title":["Autoimmunity Including Intestinal Beh\u00e7et Disease Bearing the <i>KRAS<\/i> Mutation in Lymphocytes: A Case Report"],"prefix":"10.1542","volume":"137","author":[{"given":"Hiroshi","family":"Moritake","sequence":"first","affiliation":[{"name":"Division of Pediatrics,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan; 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