{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T10:30:22Z","timestamp":1775817022359,"version":"3.50.1"},"reference-count":49,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND AND OBJECTIVES:<\/jats:title>\n                  <jats:p>A hemodynamically significant patent ductus arteriosus (PDA) can compromise perfusion and oxygenation of the preterm brain. Reports suggest that PDA is associated with increased mortality and morbidity. We hypothesize that long-standing low cerebral oxygenation due to PDA might affect brain volume at term equivalent age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>Observational study in 140 infants investigating the relationship between near-infrared spectroscopy\u2013monitored cerebral oxygen saturation (rSco2) and MRI-assessed regional brain volume and maturation of the posterior limb of the internal capsule at term-equivalent age in 3 groups: those whose PDA closed with indomethacin, those who needed additional surgical closure, and matched controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>The surgery group had the lowest rSco2 values before closure (n = 35), 48% \u00b1 9.7% (mean \u00b1 SD) as compared with the indomethacin (n = 35), 59% \u00b1 10.4 (P &amp;lt; .001), and control groups (n = 70), 66% \u00b1 6.9 (P &amp;lt; .001); the highest postnatal age before effective treatment; and the lowest volumes of most brain regions at term-equivalent age. Multiple linear regression analysis showed a significant effect of preductal closure rSco2 on cerebellar volume in this group. No differences were found in maturation of the posterior limb of the internal capsule.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Long-standing suboptimal cerebral oxygenation due to a PDA may negatively influence brain growth, affecting neurodevelopmental outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2015-3090","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T19:23:26Z","timestamp":1459365806000},"source":"Crossref","is-referenced-by-count":67,"title":["Patent Ductus Arteriosus and Brain Volume"],"prefix":"10.1542","volume":"137","author":[{"given":"Petra M.A.","family":"Lemmers","sequence":"first","affiliation":[{"name":"Department of Neonatology, Wilhelmina Children\u2019s Hospital\/University Medical Center Utrecht, Netherlands;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manon 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