{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:01:41Z","timestamp":1753887701159,"version":"3.41.2"},"reference-count":16,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"abstract":"<jats:p>A 17-year-old girl presented with facial swelling and shortness of breath to an outside emergency department. She was treated for an allergic reaction with steroids and antihistamines, and discharged from the hospital. Subsequently, she was referred as an outpatient to pediatric nephrology for recurrent edema and proteinuria. Initial laboratory workup by nephrology was significant for a normal complete blood count and reassuring electrolyte panel. Pertinent laboratories were a creatinine of 0.5 mg\/dL (0.4\u20131.1 mg\/dL) and an albumin 2.3 g\/dL (3.5\u20135.0 g\/dL). The urine protein-to-creatinine ratio was &amp;gt;7 (&amp;lt;0.2). A renal ultrasound showed symmetrically sized kidneys with normal echotexture. The patient\u2019s renal biopsy results were consistent with minimal change disease. Based on the biopsy results, prednisone was started. Due to a poor response to prednisone, an alternate immunomodulator therapy was selected. Her subsequent complete blood counts showed a downward trend of all cell lines and an elevated serum uric acid. Concurrently, she reported worsening fatigue, low back pain, nausea, vomiting, night sweats, and pruritus. More details of her case and the outcome are presented.<\/jats:p>","DOI":"10.1542\/peds.2015-3205","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T23:01:21Z","timestamp":1460156481000},"source":"Crossref","is-referenced-by-count":1,"title":["A 17-Year-Old With Steroid-Resistant Nephrotic Syndrome"],"prefix":"10.1542","volume":"137","author":[{"given":"Molly E.","family":"Band","sequence":"first","affiliation":[{"name":"Connecticut Children\u2019s Medical Center, Hartford, Connecticut; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candice","family":"Sheldon","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics, Stanford School of Medicine, Stanford University, Palo Alto, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Brancato","sequence":"additional","affiliation":[{"name":"Connecticut Children\u2019s Medical Center, Hartford, Connecticut; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nehal S.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Connecticut Children\u2019s Medical Center, Hartford, Connecticut; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"D\u2019Alessandri-Silva","sequence":"additional","affiliation":[{"name":"Connecticut Children\u2019s Medical Center, Hartford, Connecticut; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2016,5,1]]},"reference":[{"issue":"11","key":"2021120904341786900_B1","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.2165\/00002018-200831110-00006","article-title":"Serious adverse reactions of bupropion for smoking cessation: analysis of the French Pharmacovigilance Database from 2001 to 2004.","volume":"31","author":"Beyens","year":"2008","journal-title":"Drug Saf"},{"key":"2021120904341786900_B2","first-page":"1","article-title":"Edema","volume-title":"Textbook of Pediatric Emergency Medicine","author":"Ciarallo","year":"2005","edition":"5th ed"},{"key":"2021120904341786900_B3","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/978-3-540-76341-3_28","article-title":"Idiopathic nephrotic syndrome in children: clinical aspects","volume-title":"Pediatric Nephrology","author":"Niaduet","year":"2009","edition":"6th ed."},{"issue":"2","key":"2021120904341786900_B4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/ki.1978.23","article-title":"Nephrotic syndrome in children: prediction of histopathology from clinical and laboratory characteristics at time of diagnosis. 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