{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:04:18Z","timestamp":1793041458275,"version":"4.5.0"},"reference-count":49,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>CONTEXT:<\/jats:title>\n                  <jats:p>Symptoms associated with the primary tooth eruption have been extensively studied but it is still controversial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>To assess the occurrence of local and systemic signs and symptoms during primary tooth eruption.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DATA SOURCES:<\/jats:title>\n                  <jats:p>Latin American and Caribbean Health Sciences, PubMed, ProQuest, Scopus, and Web of Science were searched. A partial gray literature search was taken by using Google Scholar and the reference lists of the included studies were scanned.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY SELECTION:<\/jats:title>\n                  <jats:p>Observational studies assessing the association of eruption of primary teeth with local and systemic signs and symptoms in children aged 0 to 36 months were included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DATA EXTRACTION:<\/jats:title>\n                  <jats:p>Two authors independently collected the information from the selected articles. Information was crosschecked and confirmed for its accuracy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>A total of 1179 articles were identified, and after a 2-phase selection, 16 studies were included. Overall prevalence of signs and symptoms occurring during primary tooth eruption in children between 0 and 36 months was 70.5% (total sample = 3506). Gingival irritation (86.81%), irritability (68.19%), and drooling (55.72%) were the most frequent ones.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS:<\/jats:title>\n                  <jats:p>Different general symptoms were considered among studies. Some studies presented lack of confounding factors, no clear definition of the diagnostics methods, use of subjective measures and long intervals between examinations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>There is evidence of the occurrence of signs and symptoms during primary tooth eruption. For body temperature analyses, eruption could lead to a rise in temperature, but it was not characterized as fever.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2015-3501","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T02:39:12Z","timestamp":1455849552000},"source":"Crossref","is-referenced-by-count":48,"title":["Signs and Symptoms of Primary Tooth Eruption: A Meta-analysis"],"prefix":"10.1542","volume":"137","author":[{"given":"Carla","family":"Massignan","sequence":"first","affiliation":[{"name":"Department of Dentistry, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariane","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Department of Dentistry, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Lu\u00eds","family":"Porporatti","sequence":"additional","affiliation":[{"name":"Bauru School of Dentistry, Bauru, S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Secil","family":"Aydinoz","sequence":"additional","affiliation":[{"name":"Gulhane Military Medical Academy, Istanbul, Turkey; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziela De Luca","family":"Canto","sequence":"additional","affiliation":[{"name":"Department of Dentistry, and"},{"name":"Brazilian Centre for Evidence-based Research, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil;"},{"name":"Department of Dentistry, University of Alberta, Edmonton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Andre Mendon\u00e7a","family":"Mezzomo","sequence":"additional","affiliation":[{"name":"Department of Dentistry, and"},{"name":"Brazilian Centre for Evidence-based Research, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Bolan","sequence":"additional","affiliation":[{"name":"Department of Dentistry, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2016,3,1]]},"reference":[{"issue":"4","key":"2021121021242668300_B1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1600-0714.1980.tb00377.x","article-title":"Tooth eruption: evidence for the central role of the dental follicle.","volume":"9","author":"Cahill","year":"1980","journal-title":"J Oral Pathol"},{"issue":"2","key":"2021121021242668300_B2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1601-6343.2009.01438.x","article-title":"Mechanism and control of tooth eruption: overview and clinical implications.","volume":"12","author":"Proffit","year":"2009","journal-title":"Orthod Craniofac Res"},{"issue":"3","key":"2021121021242668300_B3","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0022-3476(75)80645-7","article-title":"Teething\u2014are today\u2019s pediatricians using yesterday\u2019s notions?","volume":"87","author":"Honig","year":"1975","journal-title":"J Pediatr"},{"issue":"6","key":"2021121021242668300_B4","first-page":"658","article-title":"Teething as a cause of death. 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