{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:39:37Z","timestamp":1793813977081,"version":"4.6.1"},"reference-count":62,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>CONTEXT:<\/jats:title>\n                  <jats:p>Several varicella vaccines are available worldwide. Countries with a varicella vaccination program use 1- or 2-dose schedules.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>We examined postlicensure estimates of varicella vaccine effectiveness (VE) among healthy children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DATA SOURCES:<\/jats:title>\n                  <jats:p>Systematic review and descriptive and meta-analysis of Medline, Embase, Cochrane libraries, and CINAHL databases for reports published during 1995\u20132014.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY SELECTION:<\/jats:title>\n                  <jats:p>Publications that reported original data on dose-specific varicella VE among immunocompetent children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DATA EXTRACTION:<\/jats:title>\n                  <jats:p>We used random effects meta-analysis models to obtain pooled one dose VE estimates by disease severity (all varicella and moderate\/severe varicella). Within each severity category, we assessed pooled VE by vaccine and by study design. We used descriptive statistics to summarize 1-dose VE against severe disease. For 2-dose VE, we calculated pooled estimates against all varicella and by study design.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>The pooled 1-dose VE was 81% (95% confidence interval [CI]: 78%\u201384%) against all varicella and 98% (95% CI: 97%\u201399%) against moderate\/severe varicella with no significant association between VE and vaccine type or study design (P &amp;gt; .1). For 1 dose, median VE for prevention of severe disease was 100% (mean = 99.4%). The pooled 2-dose VE against all varicella was 92% (95% CI: 88%\u201395%), with similar estimates by study design.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS:<\/jats:title>\n                  <jats:p>VE was assessed primarily during outbreak investigations and using clinically diagnosed varicella.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>One dose of varicella vaccine was moderately effective in preventing all varicella and highly effective in preventing moderate\/severe varicella, with no differences by vaccine. The second dose adds improved protection against all varicella.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2015-3741","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T02:11:12Z","timestamp":1455675072000},"source":"Crossref","is-referenced-by-count":247,"title":["Global Varicella Vaccine Effectiveness: A Meta-analysis"],"prefix":"10.1542","volume":"137","author":[{"given":"Mona","family":"Marin","sequence":"first","affiliation":[{"name":"National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Marti","sequence":"additional","affiliation":[{"name":"Department of Immunization, Vaccines and Biologicals, World Health Organization, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Kambhampati","sequence":"additional","affiliation":[{"name":"National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; 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