{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:36:48Z","timestamp":1788305808181,"version":"build-2803163510"},"reference-count":8,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND:<\/jats:title>\n                  <jats:p>There is currently no clear evidence that nasal-biphasic positive airway pressure (n-BiPAP) confers any advantage over nasal-continuous positive airway pressure (n-CPAP). Our hypothesis was that preterm infants born before 30 weeks' gestation and &amp;lt;2 weeks old when extubated onto n-BiPAP will have a lower risk of extubation failure than infants extubated onto n-CPAP at equivalent mean airway pressure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>We conducted an unblinded multicenter randomized trial comparing n-CPAP with n-BiPAP in infants born &amp;lt;30 weeks' gestation and &amp;lt;2 weeks old. The primary outcome variable was the rate of extubation failure within 48 hours after the first attempt at extubation. Block randomization stratified by center and gestation (&amp;lt;28 weeks or \u226528 weeks) was performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>A total of 540 infants (270 in each group) were eligible to be included in the statistical analysis; 57 (21%) of n-BiPAP group and 55 (20%) of n-CPAP group failed extubation at 48 hours postextubation (adjusted odds ratio 1.01; 95% confidence interval 0.65\u20131.56; P = .97). Subgroup analysis of infants born before and after 28 weeks\u2019 gestation showed no significant differences between the 2 groups. There were no significant differences between arms in death; oxygen requirement at 28 days; oxygen requirement at 36 weeks' corrected gestation; or intraventricular hemorrhage, necrotizing enterocolitis requiring surgery, or pneumothorax.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>This trial shows that there is no added benefit to using n-BIPAP over n-CPAP at equivalent mean airway pressure in preventing extubation failures in infants born before 30 weeks' gestation and &amp;lt;2 weeks old.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2015-4095","type":"journal-article","created":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T10:14:53Z","timestamp":1467368093000},"source":"Crossref","is-referenced-by-count":43,"title":["Biphasic Positive Airway Pressure or Continuous Positive Airway Pressure: A Randomized Trial"],"prefix":"10.1542","volume":"138","author":[{"given":"Suresh","family":"Victor","sequence":"first","affiliation":[{"name":"Newborn ICU, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, School of Biomedicine,"},{"name":"Neonatology Center of Excellence, Sidra Medical and Research Center, Doha, Qatar; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Centre for Biostatistics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Newborn ICU, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, School of Biomedicine,"},{"name":"College of Health and Social Care, University of Salford, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huma","family":"Aziz","sequence":"additional","affiliation":[{"name":"Newborn ICU, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, School of Biomedicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Lavender","sequence":"additional","affiliation":[{"name":"School of Nursing, Midwifery, and Social Work, University of Manchester, Manchester, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Extubate Trial Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2016,8,1]]},"reference":[{"issue":"2","key":"2021120904534845100_B1","first-page":"CD000143","article-title":"Nasal continuous positive airways pressure immediately after extubation for preventing morbidity in preterm infants.","author":"Davis","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"2021120904534845100_B2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/1745-6215-12-257","article-title":"EXTUBATE: a randomised controlled trial of nasal biphasic positive airway pressure vs. nasal continuous positive airway pressure following extubation in infants less than 30 weeks\u2019 gestation: study protocol for a randomised controlled trial.","volume":"12","author":"Victor","year":"2011","journal-title":"Trials"},{"key":"2021120904534845100_B3","first-page":"348","article-title":"Design and implementation of security in a data collection system for epidemiology.","volume":"120","author":"Ainsworth","year":"2006","journal-title":"Stud Health Technol Inform"},{"issue":"5","key":"2021120904534845100_B4","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/ppul.20276","article-title":"Nasal bilevel vs. continuous positive airway pressure in preterm infants.","volume":"40","author":"Migliori","year":"2005","journal-title":"Pediatr Pulmonol"},{"key":"2021120904534845100_B5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2431-12-43","article-title":"Infant flow biphasic nasal continuous positive airway pressure (BP- NCPAP) vs. infant flow NCPAP for the facilitation of extubation in infants\u2019 \u2264 1,250 grams: a randomized controlled trial.","volume":"12","author":"O\u2019Brien","year":"2012","journal-title":"BMC Pediatr"},{"issue":"2","key":"2021120904534845100_B6","doi-asserted-by":"crossref","first-page":"F85","DOI":"10.1136\/adc.2009.169219","article-title":"Nasal continuous positive airway pressure (CPAP) versus bi-level nasal CPAP in preterm babies with respiratory distress syndrome: a randomised control trial .","volume":"95","author":"Lista","year":"2010","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"7","key":"2021120904534845100_B7","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1056\/NEJMoa1214533","article-title":"A trial comparing noninvasive ventilation strategies in preterm infants.","volume":"369","author":"Kirpalani","year":"2013","journal-title":"N Engl J Med"},{"issue":"3","key":"2021120904534845100_B8","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1542\/peds.2014-0895","article-title":"Noninvasive ventilation strategies for early treatment of RDS in preterm infants: an RCT.","volume":"135","author":"Salvo","year":"2015","journal-title":"Pediatrics"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2015-4095\/1099464\/peds_20154095.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2015-4095\/1099464\/peds_20154095.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T21:53:04Z","timestamp":1639086784000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/138\/2\/e20154095\/52463\/Biphasic-Positive-Airway-Pressure-or-Continuous"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,1]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,8,1]]},"published-print":{"date-parts":[[2016,8,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2015-4095","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,1]]},"article-number":"e20154095"}}