{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:07:50Z","timestamp":1767006470814,"version":"3.41.2"},"reference-count":12,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:p>We report the first 2 cases of hepatosplenic T-cell lymphoma in adolescents diagnosed with autoimmune hepatitis under long-term treatment with azathioprine. Patients presented with fatigue, hepatosplenomegaly, and pancytopenia. The diagnosis could be confirmed performing biopsies of liver and spleen or bone marrow, which demonstrated infiltration of neoplastic T lymphocytes with the typical phenotype with both markers, CD56+ and TCR\u03b3\u03b4+. Thus, these cases emphasize the need to constantly reevaluate the administered dose and duration of thiopurines for autoimmune hepatitis, especially in adolescents.<\/jats:p>","DOI":"10.1542\/peds.2015-4245","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T09:07:41Z","timestamp":1470906461000},"source":"Crossref","is-referenced-by-count":11,"title":["Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis"],"prefix":"10.1542","volume":"138","author":[{"given":"Florian","family":"Brinkert","sequence":"first","affiliation":[{"name":"Departments of Pediatrics,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philomena","family":"Arrenberg","sequence":"additional","affiliation":[{"name":"1st Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Till","family":"Krech","sequence":"additional","affiliation":[{"name":"Pathology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enke","family":"Grabhorn","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ansgar","family":"Lohse","sequence":"additional","affiliation":[{"name":"1st Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schramm","sequence":"additional","affiliation":[{"name":"1st Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2016,9,1]]},"reference":[{"issue":"6","key":"2021120905014176900_B1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00296-002-0229-4","article-title":"Malignant lymphoma-associated autoimmune diseases--a descriptive epidemiological study.","volume":"22","author":"V\u00e1r\u00f3czy","year":"2002","journal-title":"Rheumatol Int"},{"issue":"38","key":"2021120905014176900_B2","doi-asserted-by":"crossref","first-page":"6524","DOI":"10.1038\/sj.onc.1207843","article-title":"The epidemiology of non-Hodgkin\u2019s lymphoma.","volume":"23","author":"Fisher","year":"2004","journal-title":"Oncogene"},{"issue":"6","key":"2021120905014176900_B3","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s10620-012-2525-5","article-title":"Hepatocellular carcinoma and other malignancies in autoimmune hepatitis.","volume":"58","author":"Czaja","year":"2013","journal-title":"Dig Dis Sci"},{"issue":"2","key":"2021120905014176900_B4","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/hep.24743","article-title":"Mortality and the risk of malignancy in autoimmune liver diseases: a population-based study in Canterbury, New Zealand.","volume":"55","author":"Ngu","year":"2012","journal-title":"Hepatology"},{"issue":"2","key":"2021120905014176900_B5","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jhep.2008.08.022","article-title":"Hepatic and extrahepatic malignancies in autoimmune hepatitis. A long-term follow-up in 473 Swedish patients.","volume":"50","author":"Werner","year":"2009","journal-title":"J Hepatol"},{"issue":"2","key":"2021120905014176900_B6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.critrevonc.2011.10.001","article-title":"Hepatosplenic gamma-delta T-cell lymphoma.","volume":"83","author":"Ferreri","year":"2012","journal-title":"Crit Rev Oncol Hematol"},{"issue":"1","key":"2021120905014176900_B7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cgh.2010.09.016","article-title":"A systematic review of factors that contribute to hepatosplenic T-cell lymphoma in patients with inflammatory bowel disease.","volume":"9","author":"Kotlyar","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"2021120905014176900_B8","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1021\/acs.chemrestox.5b00019","article-title":"Role of oxidative stress mediated by glutathione-s-transferase in thiopurines\u2019 toxic effects.","volume":"28","author":"Pelin","year":"2015","journal-title":"Chem Res Toxicol"},{"issue":"2","key":"2021120905014176900_B9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/MPG.0b013e31802f6424","article-title":"Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease.","volume":"44","author":"Mackey","year":"2007","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"5","key":"2021120905014176900_B10","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.crohns.2010.05.006","article-title":"Hepatosplenic T-cell lymphoma and inflammatory bowel disease.","volume":"4","author":"Thai","year":"2010","journal-title":"J Crohn\u2019s Colitis"},{"issue":"3","key":"2021120905014176900_B11","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jhep.2014.10.018","article-title":"Patient selection based on treatment duration and liver biochemistry increases success rates after treatment withdrawal in autoimmune hepatitis.","volume":"62","author":"Hartl","year":"2015","journal-title":"J Hepatol"},{"issue":"1","key":"2021120905014176900_B12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jhep.2012.09.009","article-title":"Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission.","volume":"58","author":"van Gerven","year":"2013","journal-title":"J Hepatol"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2015-4245\/1094986\/peds_20154245.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2015-4245\/1094986\/peds_20154245.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T22:08:10Z","timestamp":1639087690000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/138\/3\/e20154245\/52645\/Two-Cases-of-Hepatosplenic-T-Cell-Lymphoma-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,1]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,9,1]]},"published-print":{"date-parts":[[2016,9,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2015-4245","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"type":"print","value":"0031-4005"},{"type":"electronic","value":"1098-4275"}],"subject":[],"published":{"date-parts":[[2016,9,1]]},"article-number":"e20154245"}}