{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:14:28Z","timestamp":1791274468949,"version":"4.1.0"},"reference-count":32,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND AND OBJECTIVE:<\/jats:title>\n                  <jats:p>Evidence from randomized controlled trials in early infancy suggest that prenatal supplementation with \u03a9-3 (n-3) long-chain polyunsaturated fatty acids (LCPUFA) reduces the incidence of allergic disease characterized by an immunoglobulin E (IgE) response. We aimed to determine whether protective effects were evident in the 6-year-old offspring of women supplemented with n-3 rich fish oil during pregnancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>Six-year follow-up of children (n = 706) with a family history of allergic disease from the Docosahexaenoic Acid to Optimize Mother Infant Outcome (DOMInO) trial. Women were randomly allocated to receive n-3 LCPUFA-rich fish oil capsules (800 mg\/d docosahexaenoic acid DHA and 100mg\/d eicosapentaenoic acid) or vegetable oil capsules (without n-3 LCPUFA). Allergic disease symptoms including eczema, wheeze, rhinitis, and rhino-conjunctivitis, were assessed using the International Study of Asthma and Allergies in Childhood questionnaire and sensitization to allergens was measured by skin prick test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>There was no difference in the percentage of children with any IgE-associated allergic disease between the n-3 LCPUFA and control groups (116\/367 [31.5%] vs 106\/336 [31.5%]; adjusted relative risk, 1.04; 95% confidence interval, 0.82\u20131.33; P = .73). There was a reduction in the percentage of children sensitized to house dust mite Dermatophagoides farinae (49\/367 [13.4%] vs 68\/336 [20.3%]; adjusted relative risk, 0.67, 95% confidence interval, 0.44\u20131.00; P = .0495).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Prenatal n-3 LCPUFA supplementation did not reduce IgE-associated allergic disease at 6 years of age. Secondary outcomes were suggestive of a protective effect of the intervention on the incidence of D. farinae sensitization.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2015-4443","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T12:22:21Z","timestamp":1464178941000},"source":"Crossref","is-referenced-by-count":55,"title":["Prenatal Fish Oil Supplementation and Allergy: 6-Year Follow-up of a Randomized Controlled Trial"],"prefix":"10.1542","volume":"137","author":[{"given":"Karen P.","family":"Best","sequence":"first","affiliation":[{"name":"Healthy Mothers, Babies and Children, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia;"},{"name":"Women\u2019s & Children\u2019s Health Research Institute,"},{"name":"Discipline of Paediatrics, School of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Sullivan","sequence":"additional","affiliation":[{"name":"School of Population Health, University of Adelaide, Adelaide, South Australia, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Palmer","sequence":"additional","affiliation":[{"name":"Women\u2019s & Children\u2019s Health Research Institute,"},{"name":"School of Paediatrics and Child Health, University of Western Australia, Subiaco, Western Australia, Australia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gold","sequence":"additional","affiliation":[{"name":"Discipline of Paediatrics, School of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan (John)","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Discipline of Paediatrics, School of Medicine, and"},{"name":"Department of Respiratory and Sleep 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