{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:36:20Z","timestamp":1780983380470,"version":"3.54.1"},"reference-count":20,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:p>Bullous eruptions in patients with underlying systemic lupus erythematosus (LE) can mimic toxic-epidermal necrolysis (TEN), a rapidly progressive mucocutaneous reaction usually associated with medication use. Differentiating between classic drug-induced TEN and TEN-like cutaneous LE is important but difficult. We report a series of 3 patients with pediatric systemic LE who were admitted with severe worsening of skin disease resembling TEN. However, the initial photo-distribution of the eruption, subacute progression, limited mucosal involvement, mild systemic symptoms, supportive biopsy and laboratory results, and lack of culprit drugs was more suggestive of a TEN-like cutaneous LE. These patients recovered with various systemic immunosuppressive medications including methylprednisolone, intravenous immunoglobulin, and plasmapheresis. Our cases are rare and demonstrate key clinical and histologic features of TEN-like cutaneous LE in young patients and the importance of differentiating this entity from drug-induced TEN.<\/jats:p>","DOI":"10.1542\/peds.2015-4497","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T12:12:18Z","timestamp":1464696738000},"source":"Crossref","is-referenced-by-count":18,"title":["Toxic Epidermal Necrolysis-Like Cutaneous Lupus in Pediatric Patients: A Case Series and Review"],"prefix":"10.1542","volume":"137","author":[{"given":"JiaDe","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Dermatology,"},{"name":"Children\u2019s Hospital of Wisconsin, Milwaukee, Wisconsin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Brandling-Bennett","sequence":"additional","affiliation":[{"name":"Divisions of Dermatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic 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