{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:29:48Z","timestamp":1787160588382,"version":"build-2736575974"},"reference-count":36,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The extent to which influenza A and B infection differs remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Using active surveillance data from the Canadian Immunization Monitoring Program Active at 12 pediatric hospitals, we compared clinical characteristics and outcomes of children \u226416 years admitted with laboratory-confirmed influenza B or seasonal influenza A. We also examined factors associated with ICU admission in children hospitalized with influenza B.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Over 8 nonpandemic influenza seasons (2004-2013), we identified 1510 influenza B and 2645 influenza A cases; median ages were 3.9 and 2.0 years, respectively (P &amp;lt; .0001). Compared with influenza A patients, influenza B patients were more likely to have a vaccine-indicated condition (odds ratio [OR] = 1.30; 95% confidence interval [CI] = 1.14\u20131.47). Symptoms more often associated with influenza B were headache, abdominal pain, and myalgia (P &amp;lt; .0001 for all symptoms after adjustment for age and health status). The proportion of deaths attributable to influenza was significantly greater for influenza B (1.1%) than influenza A (0.4%); adjusted for age and health status, OR was 2.65 (95% CI = 1.18\u20135.94). A similar adjusted OR was obtained for all-cause mortality (OR = 2.95; 95% CI = 1.34\u20136.49). Among healthy children with influenza B, age \u226510 years (relative to &amp;lt;6 months) was associated with the greatest odds of ICU admission (OR = 5.79; 95% CI = 1.91\u201317.57).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Mortality associated with pediatric influenza B infection was greater than that of influenza A. Among healthy children hosptialized with influenza B, those 10 years and older had a significant risk of ICU admission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2015-4643","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T05:08:26Z","timestamp":1471410506000},"source":"Crossref","is-referenced-by-count":114,"title":["Hospitalization for Influenza A Versus B"],"prefix":"10.1542","volume":"138","author":[{"given":"Dat","family":"Tran","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Vaudry","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Paediatrics, Stollery Children\u2019s Hospital, University of Alberta, Edmonton Alberta, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Paediatrics, Montreal Children\u2019s Hospital, McGill University, Montreal, Qu\u00e9bec, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Bettinger","sequence":"additional","affiliation":[{"name":"Vaccine Evaluation Center, BC Children\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Halperin","sequence":"additional","affiliation":[{"name":"Canadian Center for Vaccinology, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Scheifele","sequence":"additional","affiliation":[{"name":"Vaccine Evaluation Center, BC Children\u2019s 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