{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:54:31Z","timestamp":1792634071099,"version":"4.5.0"},"reference-count":48,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>CONTEXT:<\/jats:title>\n                  <jats:p>Antenatal counseling in cases of agenesis of the corpus callosum (ACC) is challenging.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVES:<\/jats:title>\n                  <jats:p>To ascertain the outcome in fetuses with isolated complete ACC and partial ACC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DATA SOURCES:<\/jats:title>\n                  <jats:p>Medline, Embase, CINAHL, and Cochrane databases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY SELECTION:<\/jats:title>\n                  <jats:p>Studies reporting a prenatal diagnosis of ACC. The outcomes observed were: chromosomal abnormalities at standard karyotype and chromosomal microarray (CMA) analysis, additional anomalies detected only at prenatal MRI and at postnatal imaging or clinical evaluation, concordance between prenatal and postnatal diagnosis and neurodevelopmental outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DATA EXTRACTION:<\/jats:title>\n                  <jats:p>Meta-analyses of proportions were used to combine data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Twenty-seven studies were included. In cACC, chromosomal anomalies occurred in 4.81% (95% confidence interval [CI], 2.2\u20138.4) of the cases. Gross and fine motor control were abnormal in 4.40% (95% CI, 0.6\u201311.3) and 10.98% (95% CI, 4.1\u201320.6) of the cases, respectively, whereas 6.80% (95% CI, 1.7\u201314.9) presented with epilepsy. Abnormal cognitive status occurred in 15.16% (95% CI, 6.9\u201325.9) of cases. In partial ACC, the rate of chromosomal anomalies was 7.45% (95% CI, 2.0\u201315.9). Fine motor control was affected in 11.74% (95% CI, 0.9\u201332.1) of the cases, and 16.11% (95% CI, 2.5\u201338.2) presented with epilepsy. Cognitive status was affected in 17.25% (95% CI, 3.0\u201339.7) of cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS:<\/jats:title>\n                  <jats:p>Different neurodevelopmental tools and time of follow-up of the included studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Children wih a prenatal diagnosis of isolated ACC show several degrees of impairment in motor control, coordination, language, and cognitive status. However, in view of the large heterogeneity in outcomes measures, time at follow-up, and neurodevelopmental tools used, large prospective studies are needed to ascertain the actual occurrence of neuropsychological morbidity of children with isolated ACC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2016-0445","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T18:58:27Z","timestamp":1472669907000},"source":"Crossref","is-referenced-by-count":124,"title":["Outcomes Associated With Isolated Agenesis of the Corpus Callosum: A Meta-analysis"],"prefix":"10.1542","volume":"138","author":[{"given":"Francesco","family":"D\u2019Antonio","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health Sciences, UiT - The Artic University of Norway, Troms\u00f8, Norway;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Pagani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fondazione Poliambulanza, Brescia, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Familiari","sequence":"additional","affiliation":[{"name":"Department of Maternal-Fetal Medicine, Catholic University of the Sacred Heart, Rome, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Khalil","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Division of Developmental Sciences, St. George\u2019s University of London, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tally-Lerman","family":"Sagies","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;"},{"name":"Fetal Neurology Clinic and Paediatric Neurology Unit, Wolfson Medical Centre, Holon, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Malinger","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;"},{"name":"GYN Ultrasound Division, Tel Aviv Medical Center, Tel Aviv, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zvi","family":"Leibovitz","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;"},{"name":"Fetal Neurology Clinic and Institute of Medical Genetics, Wolfson Medical Center, Holon, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Garel","sequence":"additional","affiliation":[{"name":"Service de Radiologie, H\u00f4pital d'Enfants Armand-Trousseau, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Laure","family":"Moutard","sequence":"additional","affiliation":[{"name":"Service de Neurop\u00e9diatrie, H\u00f4pital Trousseau, H\u00f4pitaux Universitaires de l'Est Parisien, Universit\u00e9 Pierre et Marie Curie, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Pilu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Bhide","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Division of Developmental Sciences, St. George\u2019s University of London, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh","family":"Acharya","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health Sciences, UiT - The Artic University of Norway, Troms\u00f8, Norway;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Leombroni","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Chieti-Pescara, Chieti, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamberto","family":"Manzoli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Sciences, University of Chieti-Pescara, Chieti, Italy;"},{"name":"EMISAC, Ce.S.I. 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