{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:00:36Z","timestamp":1789239636913,"version":"build-2803163510"},"reference-count":23,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND:<\/jats:title>\n                  <jats:p>Recent US studies have identified a small increased risk of intussusception after rotavirus vaccination, mainly after the first dose. We examined trends in intussusception hospitalizations before (2000\u20132005) and after (2007\u20132013) rotavirus vaccine introduction to assess whether this observed temporal risk translates into more hospitalized cases at the population level.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>Intussusception hospitalizations in children &amp;lt;12 months of age were abstracted from the State Inpatient Database maintained by the Healthcare Cost and Utilization Project for 26 states that provided data from 2000 to 2013. Rates were calculated using bridged-race postcensal population estimates. Trends were analyzed by age groups (6\u201314 weeks, 15\u201324 weeks, and 25\u201334 weeks) based on the recommended ages for vaccine administration as well as 8\u201311 weeks when the majority of first doses are given. Rate ratios were calculated by using Poisson regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>No consistent change in intussusception hospitalization rates was observed among all children &amp;lt;12 months of age and among children 15 to 24 weeks and 25 to 34 weeks of age. The intussusception hospitalization rate for children aged 8 to 11 weeks was significantly elevated by 46% to 101% (range: 16.7\u201322.9 per 100\u2009000) in all postvaccine years except 2011 and 2013 compared with the prevaccine baseline (11.7 per 100\u2009000).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>The increase in the intussusception hospitalization rate in children 8 to 11 weeks when the majority of first doses of vaccine are given is consistent with recent US postlicensure studies. Given the magnitude of declines in rotavirus disease compared with this small increase in intussusception, the benefits of rotavirus vaccination outweigh the increase risk of intussusception.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2016-1082","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T09:08:48Z","timestamp":1472029728000},"source":"Crossref","is-referenced-by-count":42,"title":["Intussusception Rates Before and After the Introduction of Rotavirus Vaccine"],"prefix":"10.1542","volume":"138","author":[{"given":"Jacqueline E.","family":"Tate","sequence":"first","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Yen","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia A.","family":"Steiner","sequence":"additional","affiliation":[{"name":"Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Cortese","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh D.","family":"Parashar","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2016,9,1]]},"reference":[{"issue":"27","key":"2021120907155977500_B1","first-page":"577","article-title":"Intussusception among recipients of rotavirus vaccine\u2014United States, 1998\u20131999.","volume":"48","author":"Centers for Disease Control and Prevention (CDC)","year":"1999","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"8","key":"2021120907155977500_B2","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1056\/NEJM200102223440804","article-title":"Intussusception among infants given an oral rotavirus vaccine [published correction appears in N Engl J Med. 2001;344(20):1564].","volume":"344","author":"Murphy","year":"2001","journal-title":"N Engl J Med"},{"issue":"6","key":"2021120907155977500_B3","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1542\/peds.110.6.e67","article-title":"Intussusception, rotavirus, and oral vaccines: summary of a workshop.","volume":"110","author":"Peter","year":"2002","journal-title":"Pediatrics"},{"key":"2021120907155977500_B4","author":"Parashar","year":"2006"},{"key":"2021120907155977500_B5","author":"Cortese","year":"2009"},{"issue":"1","key":"2021120907155977500_B6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJMoa052664","article-title":"Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine.","volume":"354","author":"Vesikari","year":"2006","journal-title":"N Engl J Med"},{"issue":"1","key":"2021120907155977500_B7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa052434","article-title":"Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis.","volume":"354","author":"Ruiz-Palacios","year":"2006","journal-title":"N Engl J Med"},{"issue":"6","key":"2021120907155977500_B8","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1542\/peds.2007-3793","article-title":"Postlicensure monitoring of intussusception after RotaTeq vaccination in the United States, February 1, 2006, to September 25, 2007.","volume":"121","author":"Haber","year":"2008","journal-title":"Pediatrics"},{"issue":"1","key":"2021120907155977500_B9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/INF.0b013e3181af8605","article-title":"Real-time surveillance to assess risk of intussusception and other adverse events after pentavalent, bovine-derived rotavirus vaccine.","volume":"29","author":"Belongia","year":"2010","journal-title":"Pediatr Infect Dis J"},{"issue":"6","key":"2021120907155977500_B10","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1001\/jama.2012.97","article-title":"Risk of intussusception following administration of a pentavalent rotavirus vaccine in US 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Med"},{"issue":"8","key":"2021120907155977500_B14","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1086\/367895","article-title":"Reappraisal of the association of intussusception with the licensed live rotavirus vaccine challenges initial conclusions.","volume":"187","author":"Murphy","year":"2003","journal-title":"J Infect Dis"},{"issue":"10","key":"2021120907155977500_B15","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1097\/00006454-199810000-00018","article-title":"Lack of an apparent association between intussusception and wild or vaccine rotavirus infection.","volume":"17","author":"Rennels","year":"1998","journal-title":"Pediatr Infect Dis J"},{"issue":"9289","key":"2021120907155977500_B16","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/S0140-6736(01)06346-2","article-title":"Effect of rotavirus vaccination programme on trends in admission of infants to hospital for 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