{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T07:24:05Z","timestamp":1785914645275,"version":"3.56.0"},"reference-count":38,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVES:<\/jats:title>\n                  <jats:p>To establish the UK incidence and clinical associations of acute pancreatitis (AP) in children aged 0 to 14 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>Monthly surveillance of new cases of AP in children under 15 years of age through the British Pediatric Surveillance Unit conducted from April 2013 to April 2014 (inclusive) followed by 1-year administrative follow-up for all valid cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Ninety-four cases (48 boys) fulfilled the diagnostic criteria. The median age at diagnosis was 11.2 years (range 1.3\u201314.9). White children accounted for 61% of the cases compared with 28% from Asian and 5% from African ethnicities. Pakistani children accounted for 18 of 26 (69%) Asian patients and 19% of the total cohort. The incidence of AP in children in the United Kingdom was 0.78 per 100\u2009000\/year (95% confidence interval [CI] 0.62\u20130.96). The incidence in Pakistani children (4.55; 95% CI 2.60\u20137.39) was sevenfold greater than white children (0.63; 95% CI 0.47\u20130.83). Of the 94 cases, 35 (37%) were idiopathic; other associations were: drug therapy, 18 (19%); gallstones, 12 (13%); hereditary, 7 (7%); organic acidemias, 7 (7%); anatomic anomalies, 5 (5%); viral infections, 3 (3%); systemic diseases, 2 (2%); and trauma 1 (1%). The most common drug associations were asparaginase (28%), azathioprine (17%), and sodium valproate (17%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Although still relatively uncommon in the United Kingdom, on average there is &amp;gt;1 case of childhood AP diagnosed every week. The associations of AP have changed significantly since the 1970\u201380s. Overrepresentation of Pakistani children is worthy of further investigation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2016-1198","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T09:08:26Z","timestamp":1471424906000},"source":"Crossref","is-referenced-by-count":43,"title":["Incidence and Clinical Associations of Childhood Acute Pancreatitis"],"prefix":"10.1542","volume":"138","author":[{"given":"Abdalmonem A.","family":"Majbar","sequence":"first","affiliation":[{"name":"National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition and University of Bristol, United Kingdom;"},{"name":"Bristol Royal Hospital for Children, Bristol, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleri","family":"Cusick","sequence":"additional","affiliation":[{"name":"Bristol Royal Hospital for Children, Bristol, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Johnson","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Lynn","sequence":"additional","affiliation":[{"name":"British Paediatric Surveillance Unit, Royal College of Paediatrics and Child Health, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda P.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Musculoskeletal Research Unit, University of Bristol, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian P.H.","family":"Shield","sequence":"additional","affiliation":[{"name":"National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition and University of Bristol, United Kingdom;"},{"name":"Bristol Royal Hospital for Children, Bristol, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2016,9,1]]},"reference":[{"issue":"5","key":"2021120907175083400_B1","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1001\/archsurg.1993.01420170122019","article-title":"A clinically based classification system for acute pancreatitis. 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