{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:14:24Z","timestamp":1790255664940,"version":"4.1.0"},"reference-count":22,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND:<\/jats:title>\n                  <jats:p>For evaluation of jaundiced neonates, serum bilirubin (SB) or transcutaneous bilirubinometry (TcB) is used. Few data are available on the quantitative reduction of blood sampling by using TcB.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>We conducted a randomized controlled trial in hospitalized jaundiced neonates \u226532 weeks\u2019 gestational age. In the intervention group, TcB was used and in the control group the decision to obtain a blood sample for SB was based on visual and clinical assessment. Outcome measure was the number of blood samples before phototherapy. When TcB was &amp;lt;50 \u00b5mol\/L below the threshold for phototherapy, SB was obtained. The decision to start treatment was always based on an SB value.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>A total of 430 were randomized and included in the intention-to-treat analysis: 213 in the TcB group and 217 in the control group. In the TcB group, 104 (48.4%) had at least 1 blood sample taken for SB, versus 172 (79.3%) in the control group (difference 30.5%, 95% confidence interval 21.5\u201338.7, P &amp;lt; .001). The number of blood draws was significantly reduced by 38.5% (0.9 \u00b1 1.1 vs 1.3 \u00b1 1.0, difference \u20130.5, 95% confidence interval \u20130.7 to \u20130.3, P &amp;lt; .001). Peak of bilirubin value, indications for phototherapy, or exchange transfusion and hospitalization length were not different between groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>The use of TcB in jaundiced neonates is feasible and safe, resulting in a reduction of more than one-third in blood draws.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2016-2414","type":"journal-article","created":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T09:07:28Z","timestamp":1478250448000},"source":"Crossref","is-referenced-by-count":37,"title":["Transcutaneous Bilirubinometry in Jaundiced Neonates: A Randomized Controlled Trial"],"prefix":"10.1542","volume":"138","author":[{"given":"Bernice","family":"van den Esker-Jonker","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Amalia Children\u2019s Clinic, Isala, Zwolle, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieve","family":"den Boer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Amalia Children\u2019s Clinic, Isala, Zwolle, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne M.C.","family":"Pepping","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Amalia Children\u2019s Clinic, Isala, Zwolle, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolita","family":"Bekhof","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Amalia Children\u2019s Clinic, Isala, Zwolle, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"key":"2021120904592440900_B1","unstructured":"National Institute for Health and Clinical Excellence (NICE)\n          . Neonatal jaundice clinical guideline. May 2010 . Available at: https:\/\/www.nice.org.uk\/guidance\/cg98\/resources\/jaundice-in-newborn-babies-under-28-days-975756073669. Accessed March 10, 2016"},{"issue":"1","key":"2021120904592440900_B2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1542\/peds.114.1.297","article-title":"Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation.","volume":"114","author":"American Academy of Pediatrics Subcommittee on Hyperbilirubinemia","year":"2004","journal-title":"Pediatrics"},{"issue":"5","key":"2021120904592440900_B3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/pch\/12.5.401","article-title":"Guidelines for detection, management and prevention of hyperbilirubinemia in term and late preterm newborn infants (35 or more weeks\u2019 gestation).","volume":"12","year":"2007","journal-title":"Paediatr Child Health"},{"issue":"1","key":"2021120904592440900_B4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1542\/peds.2011-0599","article-title":"Impact of a transcutaneous bilirubinometry program on resource utilization and severe hyperbilirubinemia.","volume":"129","author":"Wainer","year":"2012","journal-title":"Pediatrics"},{"issue":"10","key":"2021120904592440900_B5","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1440-1754.2010.01801.x","article-title":"\u2018Halving the heel pricks\u2019: evaluation of a neonatal jaundice protocol incorporating the use of a transcutaneous bilirubinometer.","volume":"46","author":"Hartshorn","year":"2010","journal-title":"J Paediatr Child Health"},{"issue":"4","key":"2021120904592440900_B6","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1542\/peds.99.4.599","article-title":"Transcutaneous bilirubinometry decreases the need for serum bilirubin measurements and saves money.","volume":"99","author":"Maisels","year":"1997","journal-title":"Pediatrics"},{"issue":"7","key":"2021120904592440900_B7","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1053\/j.semperi.2014.08.007","article-title":"Transcutaneous bilirubinometry.","volume":"38","author":"Engle","year":"2014","journal-title":"Semin Perinatol"},{"issue":"12","key":"2021120904592440900_B8","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1136\/adc.2004.070292","article-title":"Can transcutaneous bilirubinometry reduce the need for serum bilirubin estimations in term and near term infants?","volume":"90","author":"Thayyil","year":"2005","journal-title":"Arch Dis Child"},{"issue":"2","key":"2021120904592440900_B9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3109\/14767058.2010.484471","article-title":"Transcutaneous bilirubin--comparing the accuracy of BiliChek\u00ae and JM 103\u00ae in a regional postnatal unit.","volume":"24","author":"Qualter","year":"2011","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"4","key":"2021120904592440900_B10","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1542\/hpeds.2014-0003","article-title":"Prioritizing a research agenda: a Delphi study of the better outcomes through research for newborns (BORN) network.","volume":"4","author":"Simpson","year":"2014","journal-title":"Hosp Pediatr"},{"issue":"1","key":"2021120904592440900_B11","doi-asserted-by":"crossref","DOI":"10.1542\/peds.114.1.e130","article-title":"An evidence-based review of important issues concerning neonatal hyperbilirubinemia.","volume":"114","author":"Ip","year":"2004","journal-title":"Pediatrics"},{"issue":"2","key":"2021120904592440900_B12","doi-asserted-by":"crossref","first-page":"e0117229","DOI":"10.1371\/journal.pone.0117229","article-title":"Risk factors for severe neonatal hyperbilirubinemia in low and middle-income countries: a systematic review and meta-analysis.","volume":"10","author":"Olusanya","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"2021120904592440900_B13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1053\/j.semperi.2011.02.014","article-title":"A global need for affordable neonatal jaundice technologies.","volume":"35","author":"Slusher","year":"2011","journal-title":"Semin Perinatol"},{"issue":"11","key":"2021120904592440900_B14","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/jp.2012.10","article-title":"Effect of universal neonatal transcutaneous bilirubin screening on blood draws for bilirubin analysis and phototherapy usage.","volume":"32","author":"Wickremasinghe","year":"2012","journal-title":"J Perinatol"},{"issue":"12","key":"2021120904592440900_B15","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1111\/j.1651-2227.2009.01505.x","article-title":"Transcutaneous bilirubinometry reduces the need for blood sampling in neonates with visible jaundice.","volume":"98","author":"Mishra","year":"2009","journal-title":"Acta Paediatr"},{"issue":"4","key":"2021120904592440900_B16","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/archdischild-2012-302384","article-title":"How to use: transcutaneous bilirubinometry.","volume":"98","author":"O\u2019Connor","year":"2013","journal-title":"Arch Dis Child Educ Pract Ed"},{"issue":"2","key":"2021120904592440900_B17","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1542\/peds.2014-1919","article-title":"Discrepancies between transcutaneous and serum bilirubin measurements.","volume":"135","author":"Taylor","year":"2015","journal-title":"Pediatrics"},{"issue":"9","key":"2021120904592440900_B18","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/jp.2015.34","article-title":"Transcutaneous bilirubin levels in newborns &lt;35 weeks\u2019 gestation.","volume":"35","author":"Maisels","year":"2015","journal-title":"J Perinatol"},{"issue":"5","key":"2021120904592440900_B19","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1542\/peds.2013-1713","article-title":"Reliability of transcutaneous bilirubin devices in preterm infants: a systematic review.","volume":"132","author":"Nagar","year":"2013","journal-title":"Pediatrics"},{"key":"2021120904592440900_B20","unstructured":"Nederlandse Vereniging voor Kindergeneeskunde\n          . Richtlijn hyperbilirubinemie bij pasgeborenen geboren na een zwangerschapsduur van meer dan 35 weken [in Dutch]. Available at: www.babyzietgeel.nl\/. Accessed August 2016"},{"issue":"6","key":"2021120904592440900_B21","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1542\/peds.107.6.1264","article-title":"Transcutaneous bilirubin measurement: a multicenter evaluation of a new device.","volume":"107","author":"Rubaltelli","year":"2001","journal-title":"Pediatrics"},{"issue":"3","key":"2021120904592440900_B22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000442195","article-title":"Effect of phototherapy on the reliability of transcutaneous bilirubin devices in term and near-term infants: a systematic review and meta-analysis.","volume":"109","author":"Nagar","year":"2016","journal-title":"Neonatology"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2016-2414\/915968\/peds_20162414.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2016-2414\/915968\/peds_20162414.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T22:03:30Z","timestamp":1639087410000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/138\/6\/e20162414\/52592\/Transcutaneous-Bilirubinometry-in-Jaundiced"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,1]]},"references-count":22,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,12,1]]},"published-print":{"date-parts":[[2016,12,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2016-2414","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,1]]},"article-number":"e20162414"}}