{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:07:55Z","timestamp":1791986875729,"version":"4.4.0"},"reference-count":31,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>To assess the prevalence, characteristics, and risk of sensorineural hearing loss (SNHL) in children with congenital cytomegalovirus infection identified through hospital-based newborn screening who were asymptomatic at birth compared with uninfected children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We included 92 case-patients and 51 controls assessed by using auditory brainstem response and behavioral audiometry. We used Kaplan\u2013Meier survival analysis to estimate the prevalence of SNHL, defined as \u226525 dB hearing level at any frequency and Cox proportional hazards regression analyses to compare SNHL risk between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>At age 18 years, SNHL prevalence was 25% (95% confidence interval [CI]: 17%\u201336%) among case-patients and 8% (95% CI: 3%\u201322%) in controls (hazard ratio [HR]: 4.0; 95% CI: 1.2\u201314.5; P = .02). Among children without SNHL by age 5 years, the risk of delayed-onset SNHL was not significantly greater for case-patients than for controls (HR: 1.6; 95% CI: 0.4\u20136.1; P = .5). Among case-patients, the risk of delayed-onset SNHL was significantly greater among those with unilateral congenital\/early-onset hearing loss than those without (HR: 6.9; 95% CI: 2.5\u201319.1; P &amp;lt; .01). The prevalence of severe to profound bilateral SNHL among case-patients was 2% (95% CI: 1%\u20139%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Delayed-onset and progression of SNHL among children with asymptomatic congenital cytomegalovirus infection continued to occur throughout adolescence. However, the risk of developing SNHL after age 5 years among case-patients was not different than in uninfected children. Overall, 2% of case-patients developed SNHL that was severe enough for them to be candidates for cochlear implantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2016-2610","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T05:10:23Z","timestamp":1487221823000},"source":"Crossref","is-referenced-by-count":185,"title":["Hearing Loss in Children With Asymptomatic Congenital Cytomegalovirus Infection"],"prefix":"10.1542","volume":"139","author":[{"given":"Tatiana M.","family":"Lanzieri","sequence":"first","affiliation":[{"name":"National Center for Immunization and Respiratory Diseases, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winnie","family":"Chung","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marily","family":"Flores","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baylor College of Medicine, Houston, Texas;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Blum","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital, Houston, Texas; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Chantal","family":"Caviness","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baylor College of Medicine, Houston, Texas;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie R.","family":"Bialek","sequence":"additional","affiliation":[{"name":"National Center for Immunization and Respiratory Diseases, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Grosse","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry A.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baylor College of Medicine, Houston, Texas;"},{"name":"P3S Corporation, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Demmler-Harrison","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baylor College of Medicine, Houston, Texas;"},{"name":"Texas Children\u2019s Hospital, Houston, Texas; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Congenital Cytomegalovirus Longitudinal Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"issue":"14","key":"2021120907560837800_B1","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1001\/jama.2010.423","article-title":"Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infection.","volume":"303","author":"Boppana","year":"2010","journal-title":"JAMA"},{"issue":"22","key":"2021120907560837800_B2","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1056\/NEJMoa1006561","article-title":"Saliva polymerase-chain-reaction assay for cytomegalovirus screening in newborns.","volume":"364","author":"Boppana","year":"2011","journal-title":"N Engl J Med"},{"issue":"5","key":"2021120907560837800_B3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/rmv.544","article-title":"New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection.","volume":"17","author":"Dollard","year":"2007","journal-title":"Rev Med Virol"},{"issue":"5","key":"2021120907560837800_B4","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1080\/00365549950163969","article-title":"Report on a long-term study of maternal and congenital cytomegalovirus infection in Sweden. Review of prospective studies available in the literature.","volume":"31","author":"Ahlfors","year":"1999","journal-title":"Scand J Infect Dis"},{"issue":"10","key":"2021120907560837800_B5","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1001\/archpedi.1982.03970460026006","article-title":"The outcome in children with congenital cytomegalovirus infection. A longitudinal follow-up study.","volume":"136","author":"Saigal","year":"1982","journal-title":"Am J Dis Child"},{"issue":"9","key":"2021120907560837800_B6","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1093\/cid\/cit018","article-title":"Long-term outcomes of congenital cytomegalovirus infection in Sweden and the United Kingdom.","volume":"56","author":"Townsend","year":"2013","journal-title":"Clin Infect Dis"},{"issue":"5","key":"2021120907560837800_B7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1055\/s-0042-1748054","article-title":"Longitudinal investigation of hearing disorders in children with congenital cytomegalovirus.","volume":"11","author":"Dahle","year":"2000","journal-title":"J Am Acad Audiol"},{"issue":"4","key":"2021120907560837800_B8","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0022-3476(97)70248-8","article-title":"Progressive and fluctuating sensorineural hearing loss in children with asymptomatic congenital cytomegalovirus infection.","volume":"130","author":"Fowler","year":"1997","journal-title":"J Pediatr"},{"issue":"12","key":"2021120907560837800_B9","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1136\/adc.59.12.1120","article-title":"Congenital cytomegalovirus infection.","volume":"59","author":"Preece","year":"1984","journal-title":"Arch Dis Child"},{"issue":"6","key":"2021120907560837800_B10","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1542\/peds.90.6.862","article-title":"Progressive hearing loss in infants with asymptomatic congenital cytomegalovirus infection.","volume":"90","author":"Williamson","year":"1992","journal-title":"Pediatrics"},{"issue":"5","key":"2021120907560837800_B11","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/0002-9378(88)90252-9","article-title":"Epidemiologic characteristics of cytomegalovirus infection in mothers and their infants.","volume":"158","author":"Yow","year":"1988","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"2021120907560837800_B12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/00003446-199508000-00003","article-title":"Thresholds for auditory brain stem responses to tones in notched noise from infants and young children with normal hearing or sensorineural hearing loss.","volume":"16","author":"Stapells","year":"1995","journal-title":"Ear Hear"},{"issue":"5","key":"2021120907560837800_B13","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3766\/jaaa.21.5.3","article-title":"Evaluation of audiometric threshold shift criteria for ototoxicity monitoring.","volume":"21","author":"Konrad-Martin","year":"2010","journal-title":"J Am Acad Audiol"},{"key":"2021120907560837800_B14","unstructured":"American Speech-Language-Hearing Association . Degree of hearing loss. Available at: www.asha.org\/public\/hearing\/Degree-of-Hearing-Loss\/. Accessed April 26, 2016"},{"key":"2021120907560837800_B15","unstructured":"Centers for Medicare and Medicaid Services . Coverage with evidence development. Cochlear implantation. Available at: www.cms.gov\/Medicare\/Coverage\/Coverage-with-Evidence-Development\/Cochlear-Implantation-.html. Accessed April 26, 2016"},{"issue":"1","key":"2021120907560837800_B16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1542\/peds.108.1.40","article-title":"Estimated prevalence of noise-induced hearing threshold shifts among children 6 to 19 years of age: the Third National Health and Nutrition Examination Survey, 1988-1994, United States.","volume":"108","author":"Niskar","year":"2001","journal-title":"Pediatrics"},{"issue":"5","key":"2021120907560837800_B17","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1542\/peds.2014-1173","article-title":"Hearing loss and congenital CMV infection: a systematic review.","volume":"134","author":"Goderis","year":"2014","journal-title":"Pediatrics"},{"issue":"5","key":"2021120907560837800_B18","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.ijporl.2012.02.026","article-title":"Hearing thresholds in children with a congenital CMV infection: a prospective study.","volume":"76","author":"Foulon","year":"2012","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"3","key":"2021120907560837800_B19","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ijporl.2010.12.008","article-title":"Hearing status in children with congenital cytomegalovirus: up-to-6-years audiological follow-up.","volume":"75","author":"Royackers","year":"2011","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"3","key":"2021120907560837800_B20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.braindev.2013.04.001","article-title":"Role of cerebral ultrasound and magnetic resonance imaging in newborns with congenital cytomegalovirus infection.","volume":"36","author":"Capretti","year":"2014","journal-title":"Brain Dev"},{"issue":"1","key":"2021120907560837800_B21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0022-3476(99)70328-8","article-title":"Newborn hearing screening: will children with hearing loss caused by congenital cytomegalovirus infection be missed?","volume":"135","author":"Fowler","year":"1999","journal-title":"J Pediatr"},{"issue":"5","key":"2021120907560837800_B22","article-title":"Delayed onset hearing loss in children with congenital CMV infection: A critique.","volume":"134","author":"Grosse","year":"2014","journal-title":"Pediatrics"},{"issue":"20","key":"2021120907560837800_B23","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1056\/NEJMra050700","article-title":"Newborn hearing screening--a silent revolution.","volume":"354","author":"Morton","year":"2006","journal-title":"N Engl J Med"},{"key":"2021120907560837800_B24","unstructured":"The CMV & Hearing Multicenter Screening (CHIMES) Study. Available at: www.uab.edu\/medicine\/chimesstudy\/. Accessed April 26, 2016"},{"issue":"12","key":"2021120907560837800_B25","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/INF.0b013e3181af6230","article-title":"Detection of cytomegalovirus DNA in dried blood spots of Minnesota infants who do not pass newborn hearing screening.","volume":"28","author":"Choi","year":"2009","journal-title":"Pediatr Infect Dis J"},{"issue":"11","key":"2021120907560837800_B26","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1002\/lary.24752","article-title":"A diagnostic paradigm including cytomegalovirus testing for idiopathic pediatric sensorineural hearing loss.","volume":"124","author":"Park","year":"2014","journal-title":"Laryngoscope"},{"issue":"5","key":"2021120907560837800_B27","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1542\/peds.2006-3441","article-title":"Newborn hearing screening and detection of congenital cytomegalovirus infection.","volume":"121","author":"Stehel","year":"2008","journal-title":"Pediatrics"},{"issue":"3","key":"2021120907560837800_B28","doi-asserted-by":"crossref","first-page":"F230","DOI":"10.1136\/archdischild-2013-305276","article-title":"Feasibility and acceptability of targeted screening for congenital CMV-related hearing loss.","volume":"99","author":"Williams","year":"2014","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"10","key":"2021120907560837800_B29","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1056\/NEJMoa1404599","article-title":"Valganciclovir for symptomatic congenital cytomegalovirus disease.","volume":"372","author":"Kimberlin","year":"2015","journal-title":"N Engl J Med"},{"issue":"1","key":"2021120907560837800_B30","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0022-3476(03)00192-6","article-title":"Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial.","volume":"143","author":"Kimberlin","year":"2003","journal-title":"J Pediatr"},{"issue":"2","key":"2021120907560837800_B31","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jpeds.2004.11.020","article-title":"Screening for congenital cytomegalovirus infection: a tapestry of controversies.","volume":"146","author":"Demmler","year":"2005","journal-title":"J Pediatr"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2016-2610\/1062888\/peds_20162610.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2016-2610\/1062888\/peds_20162610.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T03:28:22Z","timestamp":1658633302000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/139\/3\/e20162610\/53745\/Hearing-Loss-in-Children-With-Asymptomatic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,1]]},"references-count":31,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,1]]},"published-print":{"date-parts":[[2017,3,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2016-2610","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,1]]},"article-number":"e20162610"}}