{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:41:31Z","timestamp":1781134891417,"version":"3.54.1"},"reference-count":23,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND AND OBJECTIVE:<\/jats:title>\n                  <jats:p>Over the past 20 years, the prescribing of opioids has increased dramatically in North America, with parallel increases in opioid addiction, overdose, and associated deaths. We examined whether young children of women prescribed opioids were at increased risk of opioid overdose.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>We conducted a population-based, nested case control study in Ontario, Canada, between 2002 and 2015. We identified children aged \u226410 years, whose mothers received publicly funded prescriptions for an opioid or a nonsteroidal antiinflammatory drug (comparator analgesic) in the preceding year. Cases were children who presented to hospital for or died of opioid overdose. Each case was matched with 4 controls with no opioid overdose. The primary outcome was the risk of opioid overdose.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>We identified 103 children who presented to the hospital with opioid overdose and matched them with 412 controls. Half of the children with opioid overdose were &amp;lt;2 years old. Compared with controls, children with an opioid overdose were far more likely to have a mother who received a prescription opioid (unadjusted odds ratio, 2.41; 95% confidence interval, 1.68\u20133.45) and who was prescribed antidepressants. The most commonly implicated overdose opioids were codeine (53.4%), oxycodone (32.0%), and methadone (15.5%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Young children of mothers prescribed opioids are at a markedly increased risk of overdose. Physicians, pharmacists, and parents should take measures to mitigate the risk of opioid-related harm to children, such as prescribing smaller quantities, emphasizing the importance of secure medication storage, and the prompt disposal of unused opioids.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2016-2887","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T10:05:14Z","timestamp":1487585114000},"source":"Crossref","is-referenced-by-count":69,"title":["Overdose Risk in Young Children of Women Prescribed Opioids"],"prefix":"10.1542","volume":"139","author":[{"given":"Yaron","family":"Finkelstein","sequence":"first","affiliation":[{"name":"Divisions of Emergency Medicine, and"},{"name":"Clinical Pharmacology and Toxicology, Hospital for Sick Children, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada;"},{"name":"Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada;"},{"name":"The Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"Macdonald","sequence":"additional","affiliation":[{"name":"The Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"The Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco L.A.","family":"Sivilotti","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Queen\u2019s University, Kingston, Ontario, Canada;"},{"name":"Department of Biomedical and Molecular Sciences, Queen\u2019s University, Kingston, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad M.","family":"Mamdani","sequence":"additional","affiliation":[{"name":"The Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada;"},{"name":"Li Ka Shing Centre for Healthcare Analytics Research and Training, St. Michael\u2019s Hospital, Toronto, Ontario, Canada;"},{"name":"Dalla Lana School of Public Health, University of Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Juurlink","sequence":"additional","affiliation":[{"name":"The Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada;"},{"name":"Sunnybrook Research Institute, Sunnybrook Hospital, Toronto, Ontario, Canada; and"},{"name":"Departments of Medicine, Paediatrics and Health Policy, Management and Evaluation, University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Canadian Drug Safety And Effectiveness Research Network (CDSERN)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"issue":"14","key":"2021120907563357200_B1","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1001\/jama.2015.12397","article-title":"Addressing the opioid epidemic.","volume":"314","author":"Nelson","year":"2015","journal-title":"JAMA"},{"issue":"50\u201351","key":"2021120907563357200_B2","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.15585\/mmwr.mm6450a3","article-title":"Increases in drug and opioid overdose deaths--United States, 2000\u20132014.","volume":"64","author":"Rudd","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2021120907563357200_B3","article-title":"The epidemiology of drug overdoses in the United States.","author":"Paulozzi"},{"key":"2021120907563357200_B4","unstructured":"Centers for Disease Control and Prevention. 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