{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T21:43:37Z","timestamp":1758923017166,"version":"3.41.2"},"reference-count":17,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"abstract":"<jats:p>Although capillary malformations (CMs) are not usually serious health problems in themselves, they can occasionally be warning signs for syndromes with more serious or aggressive vascular malformations not readily apparent at birth or on initial examination. We describe a series of 9 patients with a common phenotype: (1) CM on the fingertips; (2) associated combined vascular (lymphatic-venous) malformations on the trunk and\/or extremities; and (3) in some cases, partial overgrowth and asymmetry of the extremities. Data were collected retrospectively for patients with CM on the fingertips who were treated at 2 Vascular Anomalies Centers from January 2006 to January 2016. All the patients presented CM and other associated vascular abnormalities from birth. CMs were centripetal in their distribution. The greater the centripetal progression of the CM, the greater the associated vascular malformation observed. Some patients also presented varying degrees of overgrowth and asymmetry. At present, we have not found a patient with CM of the fingertip without associated anomalies. In conclusion, we present a series of patients with a particular morphology of CM located on the fingertips. All cases were associated with lymphatic-venous malformations at other sites. These data lead us to recommend these patients be referred from birth to a multidisciplinary unit of vascular anomalies.<\/jats:p>","DOI":"10.1542\/peds.2016-2967","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T09:10:11Z","timestamp":1497517811000},"source":"Crossref","is-referenced-by-count":5,"title":["Fingertip Capillary Malformation and Associated Disorders: Report of 9 Cases"],"prefix":"10.1542","volume":"140","author":[{"given":"Juan Carlos","family":"L\u00f3pez-Guti\u00e9rrez","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Vascular Anomalies Center, University Hospital La Paz, Madrid, Spain; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Redondo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Vascular Anomalies Center, University Clinic of Navarra, Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Ivars","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Vascular Anomalies Center, University Clinic of Navarra, Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2017,7,1]]},"reference":[{"issue":"2","key":"2021121014413062500_B1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1542\/peds.58.2.218","article-title":"The incidence of birthmarks in the neonate.","volume":"58","author":"Jacobs","year":"1976","journal-title":"Pediatrics"},{"issue":"2","key":"2021121014413062500_B2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1525-1470.1986.tb00505.x","article-title":"Statistical survey of skin changes in Japanese neonates.","volume":"3","author":"Hidano","year":"1986","journal-title":"Pediatr Dermatol"},{"issue":"1","key":"2021121014413062500_B3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1525-1470.2006.00172.x","article-title":"One-year survey of cutaneous lesions in 1000 consecutive Iranian newborns.","volume":"23","author":"Moosavi","year":"2006","journal-title":"Pediatr Dermatol"},{"issue":"4","key":"2021121014413062500_B4","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.jaad.2008.11.020","article-title":"Physiologic changes in vascular birthmarks during early infancy: mechanisms and clinical implications.","volume":"60","author":"Cordoro","year":"2009","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"2021121014413062500_B5","first-page":"335","article-title":"Intracranial vascular anomalies in patients with periorbital lymphatic and lymphaticovenous malformations.","volume":"28","author":"Bisdorff","year":"2007","journal-title":"AJNR Am J Neuroradiol"},{"issue":"24","key":"2021121014413062500_B6","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1002\/ajmg.a.32023","article-title":"Newly delineated syndrome of congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE syndrome) in seven patients.","volume":"143A","author":"Sapp","year":"2007","journal-title":"Am J Med Genet A"},{"issue":"20","key":"2021121014413062500_B7","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1002\/ajmg.a.32517","article-title":"Capillary malformation of the lower lip, lymphatic malformation of the face and neck, asymmetry and partial\/generalized overgrowth (CLAPO): report of six cases of a new syndrome\/association.","volume":"146A","author":"L\u00f3pez-Guti\u00e9rrez","year":"2008","journal-title":"Am J Med Genet A"},{"issue":"3","key":"2021121014413062500_B8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jaad.2003.12.017","article-title":"Klippel-Tr\u00e9naunay syndrome: the importance of \u201cgeographic stains\u201d in identifying lymphatic disease and risk of complications.","volume":"51","author":"Maari","year":"2004","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"2021121014413062500_B9","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jaad.2013.05.030","article-title":"Diffuse capillary malformation with overgrowth: a clinical subtype of vascular anomalies with hypertrophy.","volume":"69","author":"Lee","year":"2013","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"2021121014413062500_B10","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/bjd.13203","article-title":"New vascular classification of port-wine stains: improving prediction of Sturge-Weber risk.","volume":"171","author":"Waelchli","year":"2014","journal-title":"Br J Dermatol"},{"issue":"1","key":"2021121014413062500_B11","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2014-3673","article-title":"Vascular anomalies classification: recommendations from the International Society for the Study of Vascular Anomalies.","volume":"136","author":"Wassef","year":"2015","journal-title":"Pediatrics"},{"issue":"21","key":"2021121014413062500_B12","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1056\/NEJMoa1213507","article-title":"Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ.","volume":"368","author":"Shirley","year":"2013","journal-title":"N Engl J Med"},{"issue":"3","key":"2021121014413062500_B13","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jaad.2014.04.062","article-title":"The \u201cbiker-glove\u201d pattern of segmental infantile hemangiomas on the hands and feet.","volume":"71","author":"Weitz","year":"2014","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"2021121014413062500_B14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/ajmg.a.36836","article-title":"PIK3CA-related overgrowth spectrum (PROS): diagnostic and testing eligibility criteria, differential diagnosis, and evaluation.","volume":"167A","author":"Keppler-Noreuil","year":"2015","journal-title":"Am J Med Genet A"},{"issue":"6","key":"2021121014413062500_B15","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.ajhg.2012.05.006","article-title":"Somatic mosaic activating mutations in PIK3CA cause CLOVES syndrome.","volume":"90","author":"Kurek","year":"2012","journal-title":"Am J Hum Genet"},{"issue":"332","key":"2021121014413062500_B16","doi-asserted-by":"crossref","first-page":"332ra42","DOI":"10.1126\/scitranslmed.aaf1164","article-title":"Somatic PIK3CA mutations as a driver of sporadic venous malformations.","volume":"8","author":"Castel","year":"2016","journal-title":"Sci Transl Med"},{"issue":"332","key":"2021121014413062500_B17","doi-asserted-by":"crossref","first-page":"332ra43","DOI":"10.1126\/scitranslmed.aad9982","article-title":"Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.","volume":"8","author":"Castillo","year":"2016","journal-title":"Sci Transl Med"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2016-2967\/910507\/peds_20162967.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2016-2967\/910507\/peds_20162967.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T04:18:26Z","timestamp":1639196306000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/140\/1\/e20162967\/38040\/Fingertip-Capillary-Malformation-and-Associated"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,1]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,7,1]]},"published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2016-2967","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"type":"print","value":"0031-4005"},{"type":"electronic","value":"1098-4275"}],"subject":[],"published":{"date-parts":[[2017,7,1]]},"article-number":"e20162967"}}