{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:27:23Z","timestamp":1790735243638,"version":"4.1.0"},"reference-count":23,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND AND OBJECTIVES:<\/jats:title>\n                  <jats:p>The actual frequency of respiratory symptoms related to congenital pulmonary malformations (CPMs) remains undetermined. The goal of this study was to prospectively evaluate the respiratory symptoms occurring in infants with prenatally diagnosed CPMs, identify factors associated with the occurrence of these symptoms, and evaluate their resolution after surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>Infectious and noninfectious respiratory symptoms were prospectively collected in a French multicenter cohort of children with CPMs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Eighty-five children were followed up to the mean age of 2.1 \u00b1 0.4 years. Six children (7%) underwent surgery during the first 28 days of life. Of the 79 remaining children, 33 (42%) had respiratory symptoms during infancy before any surgery. Wheezing was the dominant symptom (24 of 79 [30%]), and only 1 infant had documented infection of the cystic lobe. Symptoms were more frequent in children with noncystic CPMs, prenatally (P = .01) or postnatally (P &amp;lt; .03), and with postnatally hyperlucent CPMs (P &amp;lt; .01). Sixty-six children underwent surgery during the follow-up period, and 40% of them displayed symptoms after the intervention. Six children had documented pneumonia during the postoperative period. At the end of the follow-up, pectus excavatum was observed in 10 children, significantly associated with thoracotomy (P &amp;lt; .02) or with surgery before the age of 6 months (P &amp;lt; .002).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>CPMs are frequently associated with wheezing episodes. Surgery had no significant impact on these symptoms but was associated with a paradoxical increase in pulmonary infections, as well as an increased risk of pectus excavatum after thoracotomy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2016-2988","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T10:10:29Z","timestamp":1487153429000},"source":"Crossref","is-referenced-by-count":25,"title":["Respiratory Morbidity in Infants Born With a Congenital Lung Malformation"],"prefix":"10.1542","volume":"139","author":[{"given":"Celine","family":"Delestrain","sequence":"first","affiliation":[{"name":"Pneumologie P\u00e9diatrique,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naziha","family":"Khen-Dunlop","sequence":"additional","affiliation":[{"name":"Chirurgie P\u00e9diatrique, H\u00f4pital Necker-Enfants Malades, Assistance Publique-Hospitaux de Paris, Paris, France;"},{"name":"Universit\u00e9 Paris-Descartes, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Hadchouel","sequence":"additional","affiliation":[{"name":"Pneumologie P\u00e9diatrique,"},{"name":"Universit\u00e9 Paris-Descartes, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierrick","family":"Cros","sequence":"additional","affiliation":[{"name":"Pneumologie P\u00e9diatrique, Centre Hospitalier R\u00e9gional et Universitaire de Brest, Brest, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lo\u00efse","family":"Ducoin","sequence":"additional","affiliation":[{"name":"Pneumologie P\u00e9diatrique, Centre Hospitalier de Lens, Lens, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fayon","sequence":"additional","affiliation":[{"name":"Pneumologie P\u00e9diatrique, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Gibertini","sequence":"additional","affiliation":[{"name":"Pneumologie P\u00e9diatrique, Centre Hospitalier Universitaire de Tours, Tours, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Labb\u00e9","sequence":"additional","affiliation":[{"name":"Pneumologie P\u00e9diatrique, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Labouret","sequence":"additional","affiliation":[{"name":"Pneumologie P\u00e9diatrique, Centre Hospitalier Universitaire de Toulouse, Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-No\u00eblle","family":"Lebras","sequence":"additional","affiliation":[{"name":"Pneumologie P\u00e9diatrique, H\u00f4pital Universitaire Robert Debr\u00e9, Assistance Publique-Hospitaux de Paris, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Lezmi","sequence":"additional","affiliation":[{"name":"Pneumologie P\u00e9diatrique,"},{"name":"Universit\u00e9 Paris-Descartes, Paris, France;"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Respiratoires Rares, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fouad","family":"Madhi","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Maladies Respiratoires Rares, Paris, France;"},{"name":"Pneumologie P\u00e9diatrique, Centre Hospitalier Intercommunal Cr\u00e9teil,Cr\u00e9teil, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Thouvenin","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Maladies Respiratoires Rares, Paris, France;"},{"name":"Pneumologie P\u00e9diatrique, H\u00f4pital Armand Trousseau, Assistance Publique Hospitaux de Paris, Paris, France; 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