{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:22:55Z","timestamp":1794000175141,"version":"4.8.0"},"reference-count":31,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:p>Nocardiosis is a rare cause of infection that usually affects immunocompromised adult patients and might not be recognized by pediatricians. We report a fatal case of disseminated nocardiosis in a previously healthy child initially admitted for an abdominal mass with suspicion of a renal malignant tumor. The patient, originating from Mali without any medical history, displayed abdominal pain with progressive altered general status. Laboratory and imaging findings revealed lymphocytic meningitis and disseminated abscesses in the brain and the cerebellum and a large number of cystic lesions of the kidney. Despite being administered wide-spectrum antibiotics and antituberculous and antifungal therapies with an external ventricular drainage for intracranial hypertension, the patient died 6 days after his admission. Nocardia spp was cultured from a renal biopsy and the cerebrospinal fluid. Species identification and antibiotic susceptibility were obtained later, revealing a multidrug-resistant isolate of the Nocardia elegans\/aobensis\/africana complex. This case reveals the difficulties of diagnosing nocardiosis, in particular in children not known to be immunocompromised, because we face multiple differential diagnoses and the importance of treating nocardiosis appropriately because of intrinsic resistance issues.<\/jats:p>","DOI":"10.1542\/peds.2016-3131","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T08:30:30Z","timestamp":1517387430000},"source":"Crossref","is-referenced-by-count":18,"title":["Fulminant Nocardiosis Due to a Multidrug-Resistant Isolate in a 12-Year-Old Immunocompetent Child"],"prefix":"10.1542","volume":"141","author":[{"given":"Olivia","family":"Senard","sequence":"first","affiliation":[{"name":"Department of General Pediatrics and Infectious Diseases, AP-HP, Necker-Enfants malades University Hospital, Sorbonne Paris Cit\u00e9, Paris, France;"},{"name":"Necker-Pasteur Center for Infectious Diseases and Tropical Medicine, AP-HP, Necker-Enfants malades University Hospital, Paris Descartes University, Sorbonne Paris Cit\u00e9, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Blanot","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neuro-Critical Care and Anaesthesia, AP-HP, Necker-Enfants malades University Hospital, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Jouvion","sequence":"additional","affiliation":[{"name":"Infection and Epidemiology Department, Human Histopathology and Animal Models Unit, Institut Pasteur, Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronica","family":"Rodriguez-Nava","sequence":"additional","affiliation":[{"name":"French Observatory of Nocardiosis, UMR 5557-CNRS, University Lyon 1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Lortholary","sequence":"additional","affiliation":[{"name":"Necker-Pasteur Center for Infectious Diseases and Tropical Medicine, AP-HP, Necker-Enfants malades University Hospital, Paris Descartes University, Sorbonne Paris Cit\u00e9, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Join-Lambert","sequence":"additional","affiliation":[{"name":"Clinical Microbiology, AP-HP, Necker-Enfants malades University Hospital, Sorbonne Paris Cit\u00e9, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Toubiana","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics and Infectious Diseases, AP-HP, Necker-Enfants malades University Hospital, Sorbonne Paris Cit\u00e9, Paris, France;"},{"name":"Necker-Pasteur Center for Infectious Diseases and Tropical Medicine, AP-HP, Necker-Enfants malades University Hospital, Paris Descartes University, Sorbonne Paris Cit\u00e9, Paris, 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