{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T02:22:36Z","timestamp":1783390956338,"version":"3.54.6"},"reference-count":28,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND:<\/jats:title>\n                  <jats:p>Although meningitis is rare in previously healthy term infants, lumbar puncture is often performed to evaluate for source of illness. This study was performed to determine the time to detection for positive cerebrospinal fluid (CSF) cultures and to provide an update on the current epidemiology of bacterial meningitis in term infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>This study was a multicenter, retrospective review of positive CSF cultures in infants \u226490 days of age. Specimens were drawn in the emergency department or inpatient setting between January 2000 and December 2013. Cultures were deemed true pathogens or contaminant species based on the attending physician\u2019s treatment plan. Cultures from premature infants, an operative source, or those with significant medical history were excluded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>A total of 410 positive CSF culture results were included, with 53 (12.9%) true pathogens and 357 (87.1%) contaminant species. The mean \u00b1 SD time to detection for true pathogens was 28.6 \u00b1 16.8 hours (95% confidence interval, 24\u201333.2); for contaminant species, it was 68.1 \u00b1 36.2 hours (95% confidence interval, 64.3\u201371.9). Forty-three true-positive cases (81.1%) were positive in \u226436 hours. The most common pathogen was group B Streptococcus (51%), followed by Escherichia coli (13%) and Streptococcus pneumoniae (9%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>The majority of pathogenic bacteria in CSF exhibit growth within 36 hours. Most growth from CSF cultures in febrile infants is treated as contamination. The epidemiology of meningitis has remained constant, with group B Streptococcus as the predominant pathogen, despite changes noted in the epidemiology of bacteremia in this population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2016-3268","type":"journal-article","created":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T09:10:11Z","timestamp":1493284211000},"source":"Crossref","is-referenced-by-count":38,"title":["Epidemiology of Cerebrospinal Fluid Cultures and Time to Detection in Term Infants"],"prefix":"10.1542","volume":"139","author":[{"given":"Rianna","family":"Leazer","sequence":"first","affiliation":[{"name":"Children\u2019s Hospital of The King\u2019s Daughters, Norfolk, Virginia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Erickson","sequence":"additional","affiliation":[{"name":"St. Luke\u2019s Children\u2019s Hospital, Boise, 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