{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T11:41:27Z","timestamp":1769341287269,"version":"3.49.0"},"reference-count":52,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"abstract":"<jats:sec><jats:title>BACKGROUND AND OBJECTIVES:<\/jats:title><jats:p>Growth is an important criterion to evaluate health in childhood and adolescence, especially in patients depending on special dietary treatment. Phenylketonuria (PKU) is the most common inherited disease of amino acid metabolism. Patients with PKU depend on a special phenylalanine-restricted diet, low in natural protein. The study aimed to evaluate growth, growth rate, and target height in 224 patients with PKU.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Retrospective, longitudinal analysis of standardized, yearly measurements of height, weight, and calculated growth rate (SD score [SDS]) of patients with PKU aged 0 to 18 years were conducted by using the national computerized CrescNet database. Inclusion was restricted to patients carried to term with a confirmed diagnosis of PKU or mild hyperphenylalaninemia determined by newborn screening and early treatment initiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>From birth to adulthood, patients with PKU were significantly shorter than healthy German children (height SDS at 18 years: \u22120.882 \u00b1 0.108, P &amp;lt; .001). They missed their target height by 3 cm by adulthood (women: P = .02) and 5 cm (men: P = .01). In patients receiving casein hydrolysate during childhood, this was more pronounced compared with patients receiving amino acid mixtures (P &amp;lt; .001). Growth rate was significantly reduced during their first 2 years of life and in puberty (growth rate SDS: \u22121.1 to \u22120.5 m\/year, P &amp;lt; .001 and \u22120.5; P &amp;lt; .02).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Early diagnosed, treated, and continuously monitored patients with PKU showed reduced height from birth onward. During the last 2 decades, this phenomenon attenuated, probably because of advances in PKU therapy related to protein supplements and special low-protein foods.<\/jats:p><\/jats:sec>","DOI":"10.1542\/peds.2017-0015","type":"journal-article","created":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T07:30:20Z","timestamp":1509435020000},"source":"Crossref","is-referenced-by-count":22,"title":["Growth and Final Height Among Children With Phenylketonuria"],"prefix":"10.1542","volume":"140","author":[{"given":"Alena G.","family":"Thiele","sequence":"first","affiliation":[{"name":"Center for Pediatric Research Leipzig, Department of Women and Child Health, Hospital for Children and Adolescents, University Hospitals,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Gausche","sequence":"additional","affiliation":[{"name":"CrescNet Growth Network, University 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Nutr"},{"issue":"4","key":"2021121015015364500_B3","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s10545-007-0644-5","article-title":"Neonatal screening in Europe; the situation in 2004.","volume":"30","author":"Loeber","year":"2007","journal-title":"J Inherit Metab Dis"},{"key":"2021121015015364500_B4","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1007\/BF03036506","article-title":"The first treatment of phenylketonuria.","volume":"155","author":"Bickel","year":"1996","journal-title":"Eur J Pediatr"},{"key":"2021121015015364500_B5","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1542\/peds.32.3.338","article-title":"A simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants.","volume":"32","author":"Guthrie","year":"1963","journal-title":"Pediatrics"},{"key":"2021121015015364500_B6","first-page":"1015","volume-title":"The Metabolic and Molecular Basis of Inherited Metabolic Disease","author":"Scriver","year":"1998","edition":"8th ed"},{"issue":"4","key":"2021121015015364500_B7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1203\/00006450-197007000-00002","article-title":"Malnutrition with early treatment of phenylketonuria.","volume":"4","author":"Hanley","year":"1970","journal-title":"Pediatr Res"},{"issue":"8","key":"2021121015015364500_B8","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/j.1651-2227.2002.tb02852.x","article-title":"New approach to osteopenia in phenylketonuric patients.","volume":"91","author":"P\u00e9rez-Due\u00f1as","year":"2002","journal-title":"Acta Paediatr"},{"issue":"1","key":"2021121015015364500_B9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10545-006-0108-3","article-title":"Vitamin B12 and vitamin B6 supplementation is needed among adults with phenylketonuria (PKU).","volume":"29","author":"Hvas","year":"2006","journal-title":"J Inherit Metab 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Rep"},{"issue":"1","key":"2021121015015364500_B13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/ejcn.2013.218","article-title":"PKU patients on a relaxed diet may be at risk for micronutrient deficiencies.","volume":"68","author":"Rohde","year":"2014","journal-title":"Eur J Clin Nutr"},{"issue":"5","key":"2021121015015364500_B14","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1651-2227.1994.tb13075.x","article-title":"Growth and skeletal maturation in children with phenylketonuria.","volume":"83","author":"Schaefer","year":"1994","journal-title":"Acta Paediatr"},{"issue":"2","key":"2021121015015364500_B15","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1136\/adc.71.2.114","article-title":"Impaired prenatal and postnatal growth in Dutch patients with phenylketonuria.","volume":"71","author":"Verkerk","year":"1994","journal-title":"Arch Dis 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Nutr"},{"issue":"1","key":"2021121015015364500_B19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1086\/301920","article-title":"A European multicenter study of phenylalanine hydroxylase deficiency: classification of 105 mutations and a general system for genotype-based prediction of metabolic phenotype.","volume":"63","author":"Guldberg","year":"1998","journal-title":"Am J Hum Genet"},{"issue":"3","key":"2021121015015364500_B20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1136\/jmedgenet-2014-102621","article-title":"Mapping the functional landscape of frequent phenylalanine hydroxylase (PAH) genotypes promotes personalised medicine in phenylketonuria.","volume":"52","author":"Danecka","year":"2015","journal-title":"J Med Genet"},{"key":"2021121015015364500_B21","unstructured":"DaBelle Laboratory . PAHdb: phenylalnine hydroxylase locus knowledgebase. Available at: www.PAHdb.mcgill.ca. Accessed April 12, 2013"},{"key":"2021121015015364500_B22","unstructured":"University Children\u2019s Hospital, University of Leipzig . CrescNet growth network. Available at: http:\/\/crescnet.org\/. Accessed May 4, 2016"},{"issue":"2","key":"2021121015015364500_B23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1515\/JPEM.2002.15.2.149","article-title":"Auxological computer based network for early detection of disorders of growth and weight attainment.","volume":"15","author":"Keller","year":"2002","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"4","key":"2021121015015364500_B24","first-page":"180","article-title":"The calculation of target height reconsidered.","volume":"59","author":"Hermanussen","year":"2003","journal-title":"Horm Res"},{"issue":"6","key":"2021121015015364500_B25","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1055\/s-2008-1033752","article-title":"Die Wachstumsgeschwindigkeit gesunder Kinder in den ersten 16 Lebensjahren: Longitudinale Entwicklungsstudie Bonn-Dortmund.","volume":"200","author":"Brandt","year":"1988","journal-title":"Klin Padiatr"},{"issue":"8","key":"2021121015015364500_B26","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s001120170107","article-title":"Perzentile f\u00fcr den body mass index f\u00fcr das Kindes und Jugendalter unter Heranziehung verschiedener deutscher Stichproben.","volume":"149","author":"Kromeyer-Hauschild","year":"2001","journal-title":"Mschr Kinderheilk"},{"issue":"7","key":"2021121015015364500_B27","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1515\/CCLM.2002.119","article-title":"Validation of the phenylalanine\/tyrosine ratio determined by tandem mass spectrometry: sensitive newborn screening for phenylketonuria.","volume":"40","author":"Ceglarek","year":"2002","journal-title":"Clin Chem Lab Med"},{"issue":"1","key":"2021121015015364500_B28","first-page":"19","article-title":"Effect of dietary non-compliance on development in phenylketonuria\u2013studies of 14-year-old patients [in German].","volume":"25","author":"Theile","year":"1990","journal-title":"Padiatr Padol"},{"issue":"6","key":"2021121015015364500_B29","doi-asserted-by":"crossref","DOI":"10.1542\/peds.102.6.e72","article-title":"Length and body mass index at birth and target height influences on patterns of postnatal growth in children born small for gestational age.","volume":"102","author":"Luo","year":"1998","journal-title":"Pediatrics"},{"issue":"2","key":"2021121015015364500_B30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/aje\/152.2.125","article-title":"Critical growth phases for adult shortness.","volume":"152","author":"Luo","year":"2000","journal-title":"Am J Epidemiol"},{"key":"2021121015015364500_B31","unstructured":"Destatis Statistisches Bundesamt . Health status, behaviour relevant to health. Available at: https:\/\/www.destatis.de\/DE\/ZahlenFakten\/GesellschaftStaat\/Gesundheit\/GesundheitszustandRelevantesVerhalten\/Tabellen\/Koerpermasse.html. Accessed March 30, 2015"},{"key":"2021121015015364500_B32","first-page":"961","article-title":"Therapie von Patienten mit Phenylketonurie, Empfehlungen der Arbeitsgemeinschaft f\u00fcr P\u00e4diatrische Stoffwechselst\u00f6rungen (APS).","volume":"145","author":"Bremer","year":"1997","journal-title":"Monatsschr Kinderheilkd"},{"issue":"7","key":"2021121015015364500_B33","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.metabol.2008.02.008","article-title":"Secular trends in body mass index in German children and adolescents: a cross-sectional data analysis via CrescNet between 1999 and 2006.","volume":"57","author":"Meigen","year":"2008","journal-title":"Metabolism"},{"key":"2021121015015364500_B34","volume-title":"Referenzperzentile f\u00fcr anthropometrische Ma\u00dfzahlen und Blutdruck aus der Studie zur Gesundheit von Kindern und Jugendlichen in Deutschland (KiGGS)","author":"Neuhauser","year":"2013"},{"issue":"3","key":"2021121015015364500_B35","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1046\/j.1365-3016.2002.00423.x","article-title":"Growth parameters in newborns with hyperphenylalaninaemia.","volume":"16","author":"Zaffanello","year":"2002","journal-title":"Paediatr Perinat Epidemiol"},{"issue":"7","key":"2021121015015364500_B36","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/BF01957014","article-title":"Growth in patients with phenylketonuria.","volume":"153","author":"Weglage","year":"1994","journal-title":"Eur J Pediatr"},{"issue":"6, pt 2","key":"2021121015015364500_B37","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1542\/peds.112.S4.1523","article-title":"The Maternal Phenylketonuria International Study: 1984-2002.","volume":"112","author":"Koch","year":"2003","journal-title":"Pediatrics"},{"issue":"4","key":"2021121015015364500_B38","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1023\/A:1005398406988","article-title":"Aberrant phenylalanine metabolism in phenylketonuria heterozygotes.","volume":"21","author":"Guldberg","year":"1998","journal-title":"J Inherit Metab Dis"},{"issue":"7","key":"2021121015015364500_B39","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/j.1651-2227.2002.tb03331.x","article-title":"Phenylalanine hydroxylase mutations and phenylalanine-tyrosine metabolism in heterozygotes for phenylalanine hydroxylase deficiency.","volume":"91","author":"Verduci","year":"2002","journal-title":"Acta Paediatr"},{"issue":"2","key":"2021121015015364500_B40","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1006\/mgme.1999.2862","article-title":"Biochemical phenotype and its relationship with genotype in hyperphenylalaninemia heterozygotes.","volume":"67","author":"Mallolas","year":"1999","journal-title":"Mol Genet Metab"},{"issue":"2","key":"2021121015015364500_B41","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1570-677X(02)00033-3","article-title":"The secular trend in human physical growth: a biological view.","volume":"1","author":"Cole","year":"2003","journal-title":"Econ Hum Biol"},{"issue":"1","key":"2021121015015364500_B42","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1055\/s-2008-1043923","article-title":"Einfluss der Di\u00e4tbedingungen auf K\u00f6rpergewicht und -gr\u00f6sse bei Kindern mit Phenylketonurie in Ostdeutschland.","volume":"209","author":"B\u00fchrdel","year":"1997","journal-title":"Klin Padiatr"},{"key":"2021121015015364500_B43","volume-title":"Angeborene, erbliche 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Nutr"},{"issue":"7","key":"2021121015015364500_B47","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ejcn.2016.54","article-title":"Protein substitutes for phenylketonuria in Europe: access and nutritional composition.","volume":"70","author":"Pena","year":"2016","journal-title":"Eur J Clin Nutr"},{"issue":"4","key":"2021121015015364500_B48","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1542\/peds.113.4.840","article-title":"Flavor programming during infancy.","volume":"113","author":"Mennella","year":"2004","journal-title":"Pediatrics"},{"issue":"4","key":"2021121015015364500_B49","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/jhn.12346","article-title":"Food acceptance and neophobia in children with phenylketonuria: a prospective controlled study.","volume":"29","author":"Evans","year":"2016","journal-title":"J Hum Nutr 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