{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:28:09Z","timestamp":1792286889907,"version":"4.4.0"},"reference-count":24,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,1]]},"abstract":"\n BACKGROUND:<\/jats:title>\n Acetylsalicylic acid (ASA) is part of the recommended treatment of Kawasaki disease (KD). Controversies remain regarding the optimal dose of ASA to be used. We aimed to evaluate the noninferiority of ASA at an antiplatelet dose in acute KD in preventing coronary artery (CA) abnormalities.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n This is a multicenter, retrospective, nonrandomized cohort study including children 0 to 10 years of age with acute KD between 2004 and 2015 from 5 institutions, of which 2 routinely use low-dose ASA (3\u20135 mg\/kg per day) and 3 use high-dose ASA (80 mg\/kg per day). Outcomes were CA abnormalities defined as a CA diameter with a z score \u22652.5. We assessed the risk difference of CA abnormalities according to ASA dose. All subjects received ASA and intravenous immunoglobulin within 10 days of fever onset.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n There were 1213 subjects included, 848 in the high-dose and 365 in the low-dose ASA group. There was no difference in the risk of CA abnormalities in the low-dose compared with the high-dose ASA group (22.2% vs 20.5%). The risk difference adjusted for potential confounders was 0.3% (95% confidence interval [CI]: \u22124.5% to 5.0%). The adjusted risk difference for CA abnormalities persisting at the 6-week follow-up was \u22121.9% (95% CI: \u22125.3% to 1.5%). The 95% CI of the risk difference of CA abnormalities adjusted for confounders was within the prespecified 5% margin considered to be noninferior.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n In conjunction with intravenous immunoglobulin, low-dose ASA in acute KD is not inferior to high-dose ASA for reducing the risk of CA abnormalities.<\/jats:p>\n <\/jats:sec>","DOI":"10.1542\/peds.2017-0098","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T05:10:12Z","timestamp":1493701812000},"source":"Crossref","is-referenced-by-count":84,"title":["Aspirin Dose and Prevention of Coronary Abnormalities in Kawasaki Disease"],"prefix":"10.1542","volume":"139","author":[{"given":"Frederic","family":"Dallaire","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine and Health Sciences, Centre de recherche du centre hospitalier universitaire de Sherbrooke, University of Sherbrooke, Sherbrooke, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Fortier-Morissette","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine and Health Sciences, Centre de recherche du centre hospitalier universitaire de Sherbrooke, University of Sherbrooke, Sherbrooke, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Blais","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine and Health Sciences, Centre de recherche du centre hospitalier universitaire de Sherbrooke, University of Sherbrooke, Sherbrooke, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Dhanrajani","sequence":"additional","affiliation":[{"name":"Divisions of Pediatric Rheumatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dania","family":"Basodan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Montreal Children\u2019s Hospital, McGill University Health Centre, Montreal, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Renaud","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Montreal Children\u2019s Hospital, McGill University Health Centre, Montreal, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Mathew","sequence":"additional","affiliation":[{"name":"Labatt Family Heart Center, The Hospital for Sick Children and Department of Pediatrics, University of Toronto, Toronto, Canada; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid M.","family":"De Souza","sequence":"additional","affiliation":[{"name":"Cardiology, Department of Pediatrics, University of British Columbia, British Columbia Children\u2019s Hospital, Vancouver, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Dionne","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine and Health Sciences, Centre de recherche du centre hospitalier universitaire de Sherbrooke, University of Sherbrooke, Sherbrooke, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison","family":"Saulnier","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Montreal Children\u2019s Hospital, McGill University Health Centre, Montreal, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley","family":"Kaspy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Montreal Children\u2019s Hospital, McGill University Health Centre, Montreal, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soha","family":"Rached-d\u2019Astous","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagib","family":"Dahdah","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian W.","family":"McCrindle","sequence":"additional","affiliation":[{"name":"Labatt Family Heart Center, The Hospital for Sick Children and Department of Pediatrics, University of Toronto, Toronto, Canada; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek G.","family":"Human","sequence":"additional","affiliation":[{"name":"Cardiology, Department of Pediatrics, University of British Columbia, British Columbia Children\u2019s Hospital, Vancouver, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie","family":"Scuccimarri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Montreal Children\u2019s Hospital, McGill University Health Centre, Montreal, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2017,6,1]]},"reference":[{"issue":"17","key":"2021120916495407100_B1","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1161\/01.CIR.0000145143.19711.78","article-title":"Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart 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