{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:11:00Z","timestamp":1792293060287,"version":"4.4.0"},"reference-count":27,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:sec>\n                  <jats:title>CONTEXT:<\/jats:title>\n                  <jats:p>The association between acid-suppressive drug exposure during pregnancy and childhood asthma has not been well established.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>To conduct a systematic review and meta-analysis on this association to provide further justification for the current studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DATA SOURCES:<\/jats:title>\n                  <jats:p>We searched PubMed, Medline, Embase, the Cochrane Database of Systematic Reviews, EBSCO Information Services, Web of Science, and Google Scholar from inception until June 2017.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY SELECTION:<\/jats:title>\n                  <jats:p>Observational studies in which researchers assessed acid-suppressive drug use during pregnancy and the risk of childhood asthma were included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DATA EXTRACTION:<\/jats:title>\n                  <jats:p>Of 556 screened articles, 8 population-based studies were included in the final analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>When all the studies were pooled, acid-suppressive drug use in pregnancy was associated with an increased risk of asthma in childhood (relative risk [RR] = 1.45; 95% confidence interval [CI] 1.35\u20131.56; I2 = 0%; P &amp;lt; .00001). The overall risk of asthma in childhood increased among proton pump inhibitor users (RR = 1.34; 95% CI 1.18\u20131.52; I2 = 46%; P &amp;lt; .00001) and histamine-2 receptor antagonist users (RR = 1.57; 95% CI 1.46\u20131.69; I2 = 0%; P &amp;lt; .00001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS:<\/jats:title>\n                  <jats:p>None of the researchers in the studies in this meta-analysis adjusted for the full panel of known confounders in these associations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>The evidence suggests that prenatal, maternal, acid-suppressive drug use is associated with an increased risk of childhood asthma. This information may help clinicians and parents to use caution when deciding whether to take acid-suppressing drugs during pregnancy because of the risk of asthma in offspring.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2017-0889","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T08:30:31Z","timestamp":1515659431000},"source":"Crossref","is-referenced-by-count":56,"title":["Acid-Suppressive Drug Use During Pregnancy and the Risk of Childhood Asthma: A Meta-analysis"],"prefix":"10.1542","volume":"141","author":[{"given":"Tianwen","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Institute of Respiratory Diseases, School of Medicine, Zhejiang University, Zhejiang Sheng, China;"},{"name":"Department of Respiratory and Critical Care Medicine, Institute of Respiratory Diseases, The Affiliated Hospital of Guangdong Medical University, Guangdong 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