{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:52:27Z","timestamp":1793505147301,"version":"4.5.0"},"reference-count":23,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND AND OBJECTIVES:<\/jats:title>\n                    <jats:p>Impaired glucose control in very preterm infants is associated with increased morbidity, mortality, and poor neurologic outcome. Strategies based on insulin titration have been unsuccessful in achieving euglycemia in absence of an increase in hypoglycemia and mortality. We sought to assess whether glucose administration guided by continuous glucose monitoring (CGM) is more effective than standard of care blood glucose monitoring in maintaining euglycemia in very preterm infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Fifty newborns \u226432 weeks\u2019 gestation or with birth weight \u22641500 g were randomly assigned (1:1) within 48-hours from birth to receive computer-guided glucose infusion rate (GIR) with or without CGM. In the unblinded CGM group, the GIR adjustments were driven by CGM and rate of glucose change, whereas in the blinded CGM group the GIR was adjusted by using standard of care glucometer on the basis of blood glucose determinations. Primary outcome was percentage of time spent in euglycemic range (72\u2013144 mg\/dL). Secondary outcomes were percentage of time spent in mild (47\u201371 mg\/dL) and severe (&amp;lt;47 mg\/dL) hypoglycemia; percentage of time in mild (145\u2013180 mg\/dL) and severe (&amp;gt;180 mg\/dL) hyperglycemia; and glucose variability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Neonates in the unblinded CGM group had a greater percentage of time spent in euglycemic range (median, 84% vs 68%, P &amp;lt; .001) and decreased time spent in mild (P = .04) and severe (P = .007) hypoglycemia and in severe hyperglycemia (P = .04) compared with the blinded CGM group. Use of CGM also decreased glycemic variability (SD: 21.6 \u00b1 5.4 mg\/dL vs 27 \u00b1 7.2 mg\/dL, P = .01; coefficient of variation: 22.8% \u00b1 4.2% vs 27.9% \u00b1 5.0%; P &amp;lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>CGM-guided glucose titration can successfully increase the time spent in euglycemic range, reduce hypoglycemia, and minimize glycemic variability in preterm infants during the first week of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2017-1162","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T05:10:15Z","timestamp":1505452215000},"source":"Crossref","is-referenced-by-count":97,"title":["Continuous Glucose Monitoring in Very Preterm Infants: A Randomized Controlled Trial"],"prefix":"10.1542","volume":"140","author":[{"given":"Alfonso","family":"Galderisi","sequence":"first","affiliation":[{"name":"NICU, Departments of Women\u2019s and Child\u2019s Health and"},{"name":"Endocrinology Section, Department of Pediatrics, Yale University, New Haven, Connecticut;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Facchinetti","sequence":"additional","affiliation":[{"name":"Information Engineering, University of Padova, Padova, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry M.","family":"Steil","sequence":"additional","affiliation":[{"name":"Boston Children\u2019s Hospital, Boston, Massachusetts; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Ortiz-Rubio","sequence":"additional","affiliation":[{"name":"Boston Children\u2019s Hospital, Boston, Massachusetts; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cavallin","sequence":"additional","affiliation":[{"name":"Independent Statistician, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William V.","family":"Tamborlane","sequence":"additional","affiliation":[{"name":"Endocrinology Section, Department of Pediatrics, Yale University, New Haven, Connecticut;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Baraldi","sequence":"additional","affiliation":[{"name":"NICU, Departments of Women\u2019s and Child\u2019s Health and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Cobelli","sequence":"additional","affiliation":[{"name":"Information Engineering, University of Padova, Padova, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Trevisanuto","sequence":"additional","affiliation":[{"name":"NICU, Departments of Women\u2019s and Child\u2019s Health and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2017,10,1]]},"reference":[{"issue":"18","key":"2021120916061444700_B1","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1056\/NEJMoa0803725","article-title":"Early insulin therapy in very-low-birth-weight infants.","volume":"359","author":"Beardsall","year":"2008","journal-title":"N Engl J Med"},{"issue":"5","key":"2021120916061444700_B2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.jpeds.2010.04.032","article-title":"Prevalence and determinants of hyperglycemia in very low birth weight infants: cohort analyses of the NIRTURE study.","volume":"157","author":"Beardsall","year":"2010","journal-title":"J Pediatr"},{"issue":"13","key":"2021120916061444700_B3","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1056\/NEJMoa1206044","article-title":"Tight glycemic control versus standard care after pediatric cardiac surgery.","volume":"367","author":"Agus","year":"2012","journal-title":"N Engl J Med"},{"issue":"2","key":"2021120916061444700_B4","doi-asserted-by":"crossref","first-page":"F136","DOI":"10.1136\/archdischild-2012-301661","article-title":"Validation of the continuous glucose monitoring sensor in preterm infants.","volume":"98","author":"Beardsall","year":"2013","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"4","key":"2021120916061444700_B5","doi-asserted-by":"crossref","first-page":"F307","DOI":"10.1136\/adc.2004.051979","article-title":"The continuous glucose monitoring sensor in neonatal intensive care.","volume":"90","author":"Beardsall","year":"2005","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2021120916061444700_B6","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1002\/j.1536-4801.2005.tb00011.x","article-title":"1. 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