{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T19:14:34Z","timestamp":1776539674053,"version":"3.51.2"},"reference-count":14,"publisher":"American Academy of Pediatrics (AAP)","issue":"Supplement_5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,1]]},"abstract":"<jats:p>We describe a case of Omenn syndrome displaying exudative erythroderma and other characteristic features, including alopecia, absent B and na\u00efve T cells, hyper immunoglobulin E levels, and eosinophilia. A pathogenic recombination-activating RAG1 homozygous genetic mutation confirmed the diagnosis. She required frequent antibiotics at both treatment and prophylactic doses, which alone did not control her erythroderma, but her high risk of infection precluded the use of systemic agents such as cyclosporine, which would further suppress her already severely compromised immune system. Thrice-weekly topical dilute hypochlorite compresses, combined with skin acidification with a low pH emollient, were initiated to control inflammation and for cutaneous bacterial prophylaxis. She demonstrated a marked improvement in her erythroderma within days after treatment initiation. Further improvement continued with the addition of systemic corticosteroids, with resolution of erythroderma after her first dose. This case reveals for the first time that dilute topical hypochlorite and skin pH restoration holds promise to control severe dermatitis associated with immunodeficiency and inflammatory syndromes with minimal side effects.<\/jats:p>","DOI":"10.1542\/peds.2017-1249","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T08:35:25Z","timestamp":1522658125000},"page":"S408-S411","source":"Crossref","is-referenced-by-count":4,"title":["Topical Hypochlorite and Skin Acidification Improves Erythroderma of Omenn Syndrome"],"prefix":"10.1542","volume":"141","author":[{"given":"Margaret","family":"Wat","sequence":"first","affiliation":[{"name":"Department of Dermatology, Case Western Reserve University, Cleveland, Ohio;"},{"name":"University Hospitals Cleveland Medical Center, Cleveland, Ohio;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arielle","family":"Olicker","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Case Western Reserve University, Cleveland, Ohio;"},{"name":"Rainbow Babies and Children\u2019s Hospital, Cleveland, Ohio;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Meyerson","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Case Western Reserve University, Cleveland, Ohio;"},{"name":"University Hospitals Cleveland Medical Center, Cleveland, Ohio;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Nedorost","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Case Western Reserve University, Cleveland, Ohio;"},{"name":"University Hospitals Cleveland Medical Center, Cleveland, Ohio;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy S.","family":"Paller","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; and"},{"name":"Ann & Robert H. Lurie Children\u2019s Hospital, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Case Western Reserve University, Cleveland, Ohio;"},{"name":"University Hospitals Cleveland Medical Center, Cleveland, Ohio;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2018,4,1]]},"reference":[{"issue":"2","key":"2021121022081633500_B1","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1111\/pde.12522","article-title":"Cyclosporin treatment improves skin findings in Omenn syndrome.","volume":"32","author":"Caglayan Sozmen","year":"2015","journal-title":"Pediatr Dermatol"},{"issue":"1","key":"2021121022081633500_B2","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0022-3476(95)70260-1","article-title":"Treatment of Omenn syndrome by bone marrow 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