{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:58:28Z","timestamp":1753887508821,"version":"3.41.2"},"reference-count":25,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:p>Parvovirus B19 (PB19) is an important human pathogen that results in a wide spectrum of clinical outcomes, from mild, self-limiting erythema infectiosum in immunocompetent children and arthralgia in adults to lethal cytopenia in immunocompromised patients and intrauterine fetal death. However, there have been few reports of PB19 infection in neonates or young infants (aged 28\u201390 days), and no previous reports contained descriptions of PB19 infection as a cause of sepsislike syndrome in this age group. We report a case of sepsislike syndrome caused by PB19 infection in a 56-day-old infant whose mother had polyarthralgia at the time of his admission. PB19 infection was diagnosed on the basis of positive polymerase chain reaction results for PB19 DNA in the serum and cerebrospinal fluid. Positive immunoglobulin M and negative immunoglobulin G for PB19 suggested acute infection. He was admitted to the ICU because of poor peripheral circulation, but fully recovered without antibiotic administration. After excluding other possible pathogens, PB19 should be suspected as a cause of sepsislike syndrome in young infants, especially those who have close contact with PB19-infected individuals.<\/jats:p>","DOI":"10.1542\/peds.2017-1435","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T07:25:11Z","timestamp":1527751511000},"source":"Crossref","is-referenced-by-count":4,"title":["Parvovirus B19: A Cause of Sepsislike Syndrome in an Infant"],"prefix":"10.1542","volume":"141","author":[{"given":"Satoko","family":"Ugai","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Tokamachi Prefectural Hospital, Tokamachi, Niigata, Japan; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Aizawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Kanayama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tokamachi Prefectural Hospital, Tokamachi, Niigata, Japan; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2018,6,1]]},"reference":[{"issue":"3","key":"2021120917023099500_B1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1128\/CMR.15.3.485-505.2002","article-title":"Human parvovirus B19.","volume":"15","author":"Heegaard","year":"2002","journal-title":"Clin Microbiol Rev"},{"issue":"9005","key":"2021120917023099500_B2","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/S0140-6736(96)91348-3","article-title":"Human parvovirus B19 infection associated with acute hepatitis.","volume":"347","author":"Yoto","year":"1996","journal-title":"Lancet"},{"issue":"8530","key":"2021120917023099500_B3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0140-6736(87)90129-2","article-title":"Maternal serum alpha-fetoprotein\u2014a marker of fetal aplastic crisis during intrauterine human parvovirus infection.","volume":"1","author":"Carrington","year":"1987","journal-title":"Lancet"},{"issue":"3","key":"2021120917023099500_B4","doi-asserted-by":"crossref","first-page":"F196","DOI":"10.1136\/fn.73.3.F196-c","article-title":"Neonatal meningitis with human parvovirus B19 infection.","volume":"73","author":"Suzuki","year":"1995","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"2","key":"2021120917023099500_B5","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/01.inf.0000110270.38240.51","article-title":"Autoimmune hemolytic anemia and autoimmune hepatitis associated with parvovirus B19 infection.","volume":"23","author":"Nobili","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"2021120917023099500_B6","doi-asserted-by":"crossref","first-page":"e379","DOI":"10.1016\/j.ijid.2010.04.004","article-title":"Parvovirus B19 infection mimicking juvenile myelomonocytic leukemia.","volume":"14","author":"Ozdemir","year":"2010","journal-title":"Int J Infect Dis"},{"issue":"3","key":"2021120917023099500_B7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/pbc.21842","article-title":"Transient myeloproliferation mimicking JMML associated with parvovirus infection of infancy.","volume":"52","author":"Gupta","year":"2009","journal-title":"Pediatr Blood Cancer"},{"issue":"9283","key":"2021120917023099500_B8","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0140-6736(01)05905-0","article-title":"Association of human parvovirus B19 infection with acute meningoencephalitis.","volume":"358","author":"Barah","year":"2001","journal-title":"Lancet"},{"issue":"2","key":"2021120917023099500_B9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4103\/0255-0857.129819","article-title":"Fatal missed case of hemophagocytic lymphohistiocytosis co-infected with parvovirus B19 and Epstein-Barr virus in an infant: test hyperferritinaemia early.","volume":"32","author":"Kishore","year":"2014","journal-title":"Indian J Med Microbiol"},{"issue":"12","key":"2021120917023099500_B10","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1002\/jmv.23930","article-title":"Quantitation of human parvovirus B19 DNA in erythema infectiosum and aplastic crisis.","volume":"86","author":"Ishikawa","year":"2014","journal-title":"J Med Virol"},{"issue":"22","key":"2021120917023099500_B11","doi-asserted-by":"crossref","first-page":"12169","DOI":"10.1128\/JVI.78.22.12169-12178.2004","article-title":"Identification and characterization of persistent human erythrovirus infection in blood donor samples.","volume":"78","author":"Candotti","year":"2004","journal-title":"J Virol"},{"issue":"2","key":"2021120917023099500_B12","doi-asserted-by":"crossref","first-page":"e14310","DOI":"10.5812\/ircmj.14310","article-title":"Herpes simplex virus infection in neonates and young infants with sepsis.","volume":"16","author":"Amel Jamehdar","year":"2014","journal-title":"Iran Red Crescent Med J"},{"key":"2021120917023099500_B13","volume-title":"Nelson Textbook of Pediatrics","author":"Kliegman","year":"2011","edition":"19th ed."},{"issue":"6","key":"2021120917023099500_B14","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2012-1391","article-title":"Detection of viruses in young children with fever without an apparent source.","volume":"130","author":"Colvin","year":"2012","journal-title":"Pediatrics"},{"issue":"4","key":"2021120917023099500_B15","doi-asserted-by":"crossref","first-page":"314","DOI":"10.7883\/yoken.JJID.2015.366","article-title":"Time-series analysis comparing the prevalence of antibodies against nine viral species found in umbilical cord blood in Japan.","volume":"69","author":"Takemoto","year":"2016","journal-title":"Jpn J Infect Dis"},{"issue":"2","key":"2021120917023099500_B16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1471-0528.2010.02749.x","article-title":"Parvovirus B19 infection in human pregnancy.","volume":"118","author":"Lamont","year":"2011","journal-title":"BJOG"},{"issue":"9142","key":"2021120917023099500_B17","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/S0140-6736(98)06165-0","article-title":"Acute parvovirus B19 infection associated with fulminant hepatitis of favourable prognosis in young children.","volume":"352","author":"Sokal","year":"1998","journal-title":"Lancet"},{"issue":"1","key":"2021120917023099500_B18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1086\/313929","article-title":"Human parvovirus B19 infection in infancy associated with acute and chronic lymphocytic myocarditis and high cytokine levels: report of 3 cases and review.","volume":"31","author":"Nigro","year":"2000","journal-title":"Clin Infect Dis"},{"issue":"6","key":"2021120917023099500_B19","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1136\/jnnp.73.6.739","article-title":"Evidence for the role of demyelination, HLA-DR alleles, and cytokines in the pathogenesis of parvovirus B19 meningoencephalitis and its sequelae.","volume":"73","author":"Kerr","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"9","key":"2021120917023099500_B20","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1086\/342574","article-title":"Active, fulminant, lethal myocarditis associated with parvovirus B19 infection in an infant.","volume":"35","author":"Papadogiannakis","year":"2002","journal-title":"Clin Infect Dis"},{"issue":"5","key":"2021120917023099500_B21","first-page":"911","article-title":"Purpuric-like rash as cutaneous eruptions in parvovirus B19 infection in Thai infant.","volume":"37","author":"Chatproedprai","year":"2006","journal-title":"Southeast Asian J Trop Med Public Health"},{"issue":"10","key":"2021120917023099500_B22","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1007\/s12098-007-0176-x","article-title":"Laryngitis and neutropenia from parvovirus-B19.","volume":"74","author":"Ozbek","year":"2007","journal-title":"Indian J Pediatr"},{"issue":"7","key":"2021120917023099500_B23","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/INF.0b013e3181a645bd","article-title":"Parvovirus B19 infection associated with acute hepatitis in infant.","volume":"28","author":"Kim","year":"2009","journal-title":"Pediatr Infect Dis J"},{"key":"2021120917023099500_B24","doi-asserted-by":"crossref","first-page":"bcr2013010410","DOI":"10.1136\/bcr-2013-010410","article-title":"Human parvovirus B19 associated dilated cardiomyopathy.","author":"Jain","year":"2013","journal-title":"BMJ Case Rep"},{"issue":"6","key":"2021120917023099500_B25","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1542\/peds.113.6.1662","article-title":"Serious bacterial infections in febrile infants 1 to 90 days old with and without viral infections.","volume":"113","author":"Byington","year":"2004","journal-title":"Pediatrics"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2017-1435\/1065147\/peds_20171435.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2017-1435\/1065147\/peds_20171435.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T05:32:19Z","timestamp":1720330339000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/141\/6\/e20171435\/37627\/Parvovirus-B19-A-Cause-of-Sepsislike-Syndrome-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,1]]},"references-count":25,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,6,1]]},"published-print":{"date-parts":[[2018,6,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2017-1435","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"type":"print","value":"0031-4005"},{"type":"electronic","value":"1098-4275"}],"subject":[],"published":{"date-parts":[[2018,6,1]]},"article-number":"e20171435"}}