{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:34:25Z","timestamp":1784810065687,"version":"3.55.0"},"reference-count":24,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:p>Influenza-associated encephalitis and encephalopathy (IAE) is a severe complication of influenza infection with high morbidity and mortality. We present the case of a patient with IL-10RA mutation who developed encephalopathy after influenza infection. A 10-day-old boy developed recurrent fever and anal fistula. Growth failure gradually became apparent. He had been treated with antibiotics and elemental nutrition. However, the patient did not respond to the treatments. At 11 months, he suddenly developed shock with encephalopathy and multiple organ failures. He was then diagnosed with IAE. A cytokine study revealed elevated levels of IL-1 receptor antagonist, IL-2, IL-6, IL-8, IP-10, eotaxin, G-CSF, MCP-1, and IL-10. These cytokines are normally downregulated by IL-10. Genetic testing revealed a IL-10RA mutation at the 3\u2032 end of exon 4 (c.537G\u2192A). These findings might reflect an increased risk of severe IAE in patients with IL-10RA mutation.<\/jats:p>","DOI":"10.1542\/peds.2017-3548","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T07:40:31Z","timestamp":1525333231000},"source":"Crossref","is-referenced-by-count":16,"title":["<i>IL-10RA<\/i> Mutation as a Risk Factor of Severe Influenza-Associated Encephalopathy: A Case Report"],"prefix":"10.1542","volume":"141","author":[{"given":"Takashi","family":"Ishige","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Gunma University, Maebashi, Japan;"},{"name":"Cell Biology Program, Inflammatory Bowel Disease Centre, The Hospital for Sick Children, Toronto, Canada; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Gunma University, Maebashi, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Hatori","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Gunma University, Maebashi, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiko","family":"Tatsuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Gunma University, Maebashi, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoji","family":"Sasahara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Tohoku University, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Gunma University, Maebashi, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Gunma University, Maebashi, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2018,6,1]]},"reference":[{"key":"2021120916285982500_B1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"Interleukin-10 and the interleukin-10 receptor.","volume":"19","author":"Moore","year":"2001","journal-title":"Annu Rev Immunol"},{"issue":"3","key":"2021120916285982500_B2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nri2711","article-title":"The regulation of IL-10 production by immune cells.","volume":"10","author":"Saraiva","year":"2010","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"2021120916285982500_B3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/ibd.22974","article-title":"IL-10R polymorphisms are associated with very-early-onset ulcerative colitis.","volume":"19","author":"Moran","year":"2013","journal-title":"Inflamm Bowel Dis"},{"issue":"5","key":"2021120916285982500_B4","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/sji.12470","article-title":"Association of interleukin 10 gene polymorphisms with autoimmune thyroid disease: meta-analysis.","volume":"84","author":"Jung","year":"2016","journal-title":"Scand J Immunol"},{"issue":"6","key":"2021120916285982500_B5","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00431-016-2711-0","article-title":"Association of cytokine gene polymorphisms and risk factors with otitis media proneness in children.","volume":"175","author":"Miljanovi\u0107","year":"2016","journal-title":"Eur J Pediatr"},{"issue":"9","key":"2021120916285982500_B6","doi-asserted-by":"crossref","first-page":"e0137727","DOI":"10.1371\/journal.pone.0137727","article-title":"Evaluation of TNF-\u03b1, IL-10 and IL-6 cytokine production and their correlation with genotype variants amongst tuberculosis patients and their household contacts.","volume":"10","author":"Joshi","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"2021120916285982500_B7","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1053\/j.gastro.2014.07.023","article-title":"The diagnostic approach to monogenic very early onset inflammatory bowel disease.","volume":"147","author":"Uhlig","year":"2014","journal-title":"Gastroenterology"},{"issue":"1","key":"2021120916285982500_B8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s10875-016-0339-5","article-title":"Targeted sequencing and immunological analysis reveal the involvement of primary immunodeficiency genes in pediatric IBD: a Japanese multicenter study.","volume":"37","author":"Suzuki","year":"2017","journal-title":"J Clin Immunol"},{"key":"2021120916285982500_B9","unstructured":"WHO\n          . 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