{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:52:27Z","timestamp":1791377547576,"version":"4.3.2"},"reference-count":32,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVES:<\/jats:title>\n                  <jats:p>To assess the risk of adverse health outcomes for infants after assisted reproductive technology (ART)\u2013treated and subfertile as compared with fertile deliveries.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>Live-born singleton infants \u226523 weeks\u2019 gestational age (GA) born in Massachusetts between July 1, 2004, and December 31, 2010, were analyzed by linking a clinical ART database with state vital records. \u03c72 tests were used to compare the outcomes of fertile (those without ART treatment or other indicators of infertility), subfertile (indicators of infertility, no ART), and ART-treated (linked to ART deliveries) mothers, stratified by GA. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were calculated by using multivariate logistic regression within each GA stratum, controlling for maternal sociodemographic and health characteristics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Compared with infants of fertile mothers (n = 336\u2009705), infants born to subfertile (n = 5043) or ART-treated (n = 8375) mothers were more likely to be preterm (aOR 1.39 [95% CI 1.26\u20131.54] and aOR 1.72 [95% CI 1.60\u20131.85], respectively) and have respiratory and gastrointestinal and\/or nutritional conditions (aOR range: 1.12\u20131.18). When stratified by GA, infants of subfertile or ART-treated mothers were at greater risk for congenital malformations and infectious diseases as well as cardiovascular and respiratory conditions (aOR range: 1.30\u20132.61; 95% CI range: 1.02\u20134.59). Compared with infants born to subfertile mothers, infants born to ART-treated mothers were at lower risk for being small for GA and having congenital malformations and cardiovascular conditions and at higher risk for infectious disease conditions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Compared with infants born to fertile mothers, infants of subfertile and ART-treated mothers are at greater risk for adverse health outcomes at birth beyond prematurity. The occurrence and magnitude of these risks vary by GA and organ systems.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2017-4069","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T07:25:16Z","timestamp":1530602716000},"source":"Crossref","is-referenced-by-count":39,"title":["Health of Infants After ART-Treated, Subfertile, and Fertile Deliveries"],"prefix":"10.1542","volume":"142","author":[{"given":"Sunah S.","family":"Hwang","sequence":"first","affiliation":[{"name":"Section of Neonatology, Department of Pediatrics, School of Medicine, University of Colorado, Aurora, Colorado;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Dukhovny","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oregon Health & Science University, Portland, Oregon;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daksha","family":"Gopal","sequence":"additional","affiliation":[{"name":"Departments of Biostatistics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Cabral","sequence":"additional","affiliation":[{"name":"Departments of Biostatistics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Missmer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, East Lansing, Michigan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafsatou","family":"Diop","sequence":"additional","affiliation":[{"name":"Office of Data Translation, Massachusetts Department of Public Health, Boston, Massachusetts; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Declercq","sequence":"additional","affiliation":[{"name":"Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy E.","family":"Stern","sequence":"additional","affiliation":[{"name":"Dartmouth-Hitchcock, Lebanon, New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2018,8,1]]},"reference":[{"key":"2021121103355293200_B1","unstructured":"Centers for Disease Control and Prevention\n          . What is assisted reproductive technology? Available at: https:\/\/www.cdc.gov\/art\/whatis.html. 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