{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:48:11Z","timestamp":1790858891392,"version":"4.1.0"},"reference-count":35,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:sec>\n                  <jats:title\/>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVES:<\/jats:title>\n                  <jats:p>To characterize ophthalmic manifestations of confirmed or suspected antenatal Zika virus (ZIKV) exposure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>Infants with antenatal ZIKV exposure were referred for evaluation during the 2015\u20132016 Rio de Janeiro outbreak. Mothers with symptomatic ZIKV infection during pregnancy and\/or infants with microcephaly or other findings that were suggestive of suspected antenatal exposure were tested with reverse transcriptase polymerase chain reaction (RT-PCR). Complete eye examinations were performed by pediatric ophthalmologists between January 2016 and February 2017. The main outcome measure was eye abnormalities in RT-PCR\u2013positive and suspected (ie, not tested or RT-PCR\u2013negative) antenatal ZIKV cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Of 224 infants, 189 had RT-PCR testing performed. Of 189 patients, 156 had positive RT-PCR results in their blood, urine, and\/or placenta. Of 224 infants, 90 had central nervous system (CNS) abnormalities, including microcephaly (62 infants). Eye abnormalities were present in 57 of 224 (25.4%) infants. Optic nerve (44 of 57; 77.2%) and retina abnormalities (37 of 57; 64.9%) were the most common. The group with suspected ZIKV infection (68 infants) had proportionally more eye (36.8% vs 20.5%; P = .022) and CNS abnormalities (68.3% vs 28.1%; P = .008), likely because of referral patterns. Eye abnormalities consistent with ZIKV infection were clinically comparable in both RT-PCR\u2013positive and unconfirmed groups, including 4 RT-PCR\u2013positive infants of 5 without any CNS abnormalities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Similar eye manifestations were identified regardless of laboratory confirmation. Well-appearing infants were also found to have eye abnormalities. Therefore, all infants born after ZIKV outbreaks should be universally screened for eye abnormalities.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2018-1104","type":"journal-article","created":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T07:25:20Z","timestamp":1536823520000},"source":"Crossref","is-referenced-by-count":45,"title":["Eye Findings in Infants With Suspected or Confirmed Antenatal Zika Virus Exposure"],"prefix":"10.1542","volume":"142","author":[{"given":"Irena","family":"Tsui","sequence":"first","affiliation":[{"name":"Department of Opthalmology, Retina Division, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elisabeth Lopes","family":"Moreira","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade da Mulher da Crian\u00e7a e do Adolescente Fernandes Figueira and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia D.","family":"Rossetto","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade da Mulher da Crian\u00e7a e do Adolescente Fernandes Figueira and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilton","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade da Mulher da Crian\u00e7a e do Adolescente Fernandes Figueira and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"Gaw","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Services, University of California, San Francisco, San Francisco, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza M.","family":"Neves","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade da Mulher da Crian\u00e7a e do Adolescente Fernandes Figueira and"},{"name":"Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia A.","family":"Zin","sequence":"additional","affiliation":[{"name":"Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Haefeli","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade da Mulher da Crian\u00e7a e do Adolescente Fernandes Figueira and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel Carlos Barros","family":"Silveira Filho","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Universidade Unigranrio, Rio de Janeiro, Brazil; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Saint Clair","family":"Gomes","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade da Mulher da Crian\u00e7a e do Adolescente Fernandes Figueira and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Disease, University of California, Los Angeles, Los Angeles, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Vinicius da Silva","family":"Pone","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade da Mulher da Crian\u00e7a e do Adolescente Fernandes Figueira and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila Moura","family":"Pone","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade da Mulher da Crian\u00e7a e do Adolescente Fernandes Figueira and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Jose Paulo","family":"Pereira","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade da Mulher da Crian\u00e7a e do Adolescente Fernandes Figueira and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubens","family":"Belfort","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaithilingaraja","family":"Arumugaswami","sequence":"additional","affiliation":[{"name":"Department of Opthalmology, Retina Division, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Brasil","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Infectologia Evandro Chagas, Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Nielsen-Saines","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Disease, University of California, Los Angeles, Los Angeles, 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