{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:01:50Z","timestamp":1789758110528,"version":"4.0.1"},"reference-count":30,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND AND OBJECTIVES:<\/jats:title>\n                  <jats:p>Congenital hypothyroidism (CHT) is one of the most common preventable causes of learning disability. Newborn screening with whole-blood thyroid-stimulating hormone measurements was introduced in the Republic of Ireland in 1979 and is coordinated from a single center with an unchanged protocol since its inception. Our objective in this study was to describe the incidence of CHT in the Republic of Ireland over the past 37 years in the context of a complete national population and an unchanged screening protocol.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>The newborn screening records of all individuals who were diagnosed with CHT between 1979 and 2016 were reviewed. Infants with positive screening results had a whole-blood thyroid-stimulating hormone value of \u226515 mU\/L at 72 to 120 hours of life; values of 8 to 15 mU\/L required a repeat whole-blood screening test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Of 2\u2009361\u2009174 infants who were screened between July 1979 and December 2016, 1063 (662 girls) were diagnosed with CHT (incidence: 0.45 cases per 1000 live births). The number of detected cases increased from 0.27 cases per 1000 live births treated between 1979 and 1991 to 0.41 cases per 1000 live births treated between 1992 and 2004 to 0.65 cases per 1000 live births treated between 2005 and 2016. The increase in detected cases of CHT was predominantly in the normal or hyperplastic gland category.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>The incidence of CHT has increased significantly in the Republic of Ireland over the past 37 years despite a consistent screening cutoff. The increased rate was not explained by an increased survival rate of preterm infants or a changing population heterogeneity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2018-1199","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T07:27:08Z","timestamp":1537514828000},"source":"Crossref","is-referenced-by-count":56,"title":["Incidence of Congenital Hypothyroidism Over 37 Years in Ireland"],"prefix":"10.1542","volume":"142","author":[{"given":"Niamh","family":"McGrath","sequence":"first","affiliation":[{"name":"Department of Paediatric Endocrinology and"},{"name":"School of Medicine and Medical Science, University College Dublin, Dublin, Ireland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin P.","family":"Hawkes","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciara M.","family":"McDonnell","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan","family":"Cody","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Our Lady\u2019s Children\u2019s Hospital, Dublin, Ireland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"O\u2019Connell","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Cork University Hospital, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip D.","family":"Mayne","sequence":"additional","affiliation":[{"name":"National Newborn Bloodspot Screening Laboratory, Temple Street Children\u2019s University Hospital, Dublin, Ireland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuala P.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology and"},{"name":"School of Medicine and Medical Science, University College Dublin, Dublin, Ireland;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2018,10,1]]},"reference":[{"issue":"3","key":"2021121021324879400_B1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ymgme.2007.03.012","article-title":"Increase in congenital hypothyroidism in New York State and in the United States.","volume":"91","author":"Harris","year":"2007","journal-title":"Mol Genet Metab"},{"issue":"2","key":"2021121021324879400_B2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1046\/j.1440-1754.2002.00812.x","article-title":"Congenital hypothyroidism in Western Australia 1981-1998.","volume":"38","author":"Kurinczuk","year":"2002","journal-title":"J Paediatr Child Health"},{"key":"2021121021324879400_B3","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1542\/peds.2009-1975D","article-title":"Trends in incidence rates of congenital hypothyroidism related to select demographic factors: data from the United States, California, Massachusetts, New York, and Texas.","volume":"125","author":"Hinton","year":"2010","journal-title":"Pediatrics"},{"issue":"6254","key":"2021121021324879400_B4","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1136\/bmj.281.6254.1519","article-title":"Screening for congenital hypothyroidism in the Republic of Ireland.","volume":"281","author":"Dockeray","year":"1980","journal-title":"Br Med J"},{"issue":"4","key":"2021121021324879400_B5","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1136\/adc.2010.190280","article-title":"Prevention of intellectual disability through screening for congenital hypothyroidism: how much and at what level?","volume":"96","author":"Grosse","year":"2011","journal-title":"Arch Dis Child"},{"key":"2021121021324879400_B6","first-page":"13","article-title":"Optimising outcome in congenital hypothyroidism; 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